Bioactive Nanogels Mimicking the Antithrombogenic Nitric Oxide‐Release Function of the Endothelium

Hosseinnejad, Aisa; Ludwig, Nadine; Mersmann, Sina; Winnerbach, Patrick; Berne, Christian; Rossaint, Rolf; Rossaint, Jan; Singh, Smriti

doi:10.1002/smll.202205185

Cited by 8 publications

(1 citation statement)

References 69 publications

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“…Hosseinnejad et al prepared highly hydrophilic nanogels (NOrel-NGs) crosslinked by a diselenide bond and used the diselenide bond to catalyze and maintain the endogenous NO production of physiological NO donor (S-nitrosoglutathione), thereby inhibiting platelet activation. This provides ideas for antithrombotic treatment and prevention of thrombosis [115]. The hydrogel, responsive to mechanical stress, releases thrombolytic drugs in response to the specific shear stress environment at the surface of thrombi.…”

Section: Hydrogel Nanoparticles For Thrombolytic Drug Deliverymentioning

confidence: 99%

Advances in Nano-Functional Materials in Targeted Thrombolytic Drug Delivery

Ren,

Mi,

Wei

et al. 2024

Molecules

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Thrombotic disease has been listed as the third most fatal vascular disease in the world. After decades of development, clinical thrombolytic drugs still cannot avoid the occurrence of adverse reactions such as bleeding. A number of studies have shown that the application of various nano-functional materials in thrombus-targeted drug delivery, combined with external stimuli, such as magnetic, near-infrared light, ultrasound, etc., enrich the drugs in the thrombus site and use the properties of nano-functional materials for collaborative thrombolysis, which can effectively reduce adverse reactions such as bleeding and improve thrombolysis efficiency. In this paper, the research progress of organic nanomaterials, inorganic nanomaterials, and biomimetic nanomaterials for drug delivery is briefly reviewed.

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Section: Hydrogel Nanoparticles For Thrombolytic Drug Deliverymentioning

confidence: 99%