Bioactive nanofibrous structures based on hyaluronic acid

Abstract

Studies related to selection of molar mass of hyaluronic acid and analysis of rheological properties of hyaluronic acid solutions modified with bioactive substances, used in spinning, were undertaken within the presented work. A cephalosporin group antibiotic, Biofuroxime ® , was used, together with the nanoadditives zinc oxide (ZnO) and hydroxyapatite (HAp). Electrospinning studies were performed on selected solutions using a large scale laboratory station, allowing the process to be performed using three nozzles supplying the spinning solution. Optimum electrospinning conditions were selected on the basis of the performed study, which allow fibrous structures made of elementary fibres with diameters below 200 nm to be obtained. Studies showed that the most preferred distance between the nozzle and the collecting manifold was 450 mm and the most preferred applied voltage was 30 kV. The obtained, modified nanofibres of hyaluronic acid comprise structures for use in the production of biomaterials with a wide range of applications in tissue engineering.

From Traditional Industry to Smart Regional Specialisation: Textile Industry Transformation in the Łódź Region

“…Various elements and compounds, such as silver, zinc oxide, copper or natural polysaccharide compounds, such as chitosan, were used for modification (Fig. 5) [21][22][23][24]. Other solutions involved the development of filtering materials that can act as barriers to pollutants, bacteria or viruses.…”

Latest Progress in Electrospun Nanofibers for Wound Healing Applications

“…Fibers collect on the anode, forming a continuous fiber mat as shown in Figure . Fiber morphology and mechanical characteristics of electrospun fibers are governed by process parameters such as applied voltage, feed rate and needle tip-collector distance, system properties such as solution viscosity, solvent volatility, polymer molecular weight, and solution conductivity, and environmental conditions. , …”

“…82 Conversely, one drawback is the high viscosity of hyaluronic acid solutions, even at low concentrations, which makes the electrospinning challenging. Despite this limitation, Pabjanćzyk-Wlazło et al 53,82 optimized the electrospinning process parameters to fabricate hyaluronic acid nanofibrous mats enriched with nanoadditives or antibiotics, which promote their use for various biomedical purposes. Additionally, a hyaluronic acid/ gelatin electrospun scaffold was made by Ebrahimi-Hosseinzadeh et al 83 in which they applied the scaffold to second degree burn wounds in Wistar rats and observed faster wound closure.…”

Assessment of the Impact of the Surface Modification Processes of Cotton and Polyester Fabrics with Various Techniques on Their Structural, Biophysical, Sensory, and Mechanical Properties

“…One of the goals of the modification is to improve the properties of functional clothing parameters, affecting the safety of a selected group of users working in extremal environmental conditions like firefighters, rescuers, steel workers [ 26 , 27 , 28 , 29 , 30 ] as well as soldiers and policemen [ 31 , 32 , 33 , 34 , 35 , 36 ]. Surface modification is also commonly used in garments with healing properties [ 37 , 38 , 39 , 40 , 41 , 42 ] as well as smart clothing textiles that monitor the user’s life processes [ 43 , 44 , 45 , 46 , 47 , 48 ]. Surface modification is also commonly used for decorative clothing purposes [ 49 , 50 , 51 , 52 , 53 ].…”