Bioactive Molecules Derived from Plants in Managing Dengue Vector Aedes aegypti (Linn.)

Abstract

Mosquitoes are the potential vectors of several viral diseases such as filariasis, malaria, dengue, yellow fever, Zika fever and encephalitis in humans as well as other species. Dengue, the most common mosquito-borne disease in humans caused by the dengue virus is transmitted by the vector Ae. aegypti. Fever, chills, nausea and neurological disorders are the frequent symptoms of Zika and dengue. Thanks to various anthropogenic activities such as deforestation, industrialized farming and poor drainage facilities there has been a significant rise in mosquitoes and vector-borne diseases. Control measures such as the destruction of mosquito breeding places, a reduction in global warming, as well as the use of natural and chemical repellents, mainly DEET, picaridin, temephos and IR-3535 have proven to be effective in many instances. Although potent, these chemicals cause swelling, rashes, and eye irritation in adults and children, and are also toxic to the skin and nervous system. Due to their shorter protection period and harmful nature towards non-target organisms, the use of chemical repellents is greatly reduced, and more research and development is taking place in the field of plant-derived repellents, which are found to be selective, biodegradable and harmless to non-target species. Many tribal and rural communities across the world have been using plant-based extracts since ancient times for various traditional and medical purposes, and to ward off mosquitoes and various other insects. In this regard, new species of plants are being identified through ethnobotanical surveys and tested for their repellency against Ae. aegypti. This review aims to provide insight into many such plant extracts, essential oils and their metabolites, which have been tested for their mosquitocidal activity against different life cycle forms of Ae. Aegypti, as well as for their efficacy in controlling mosquitoes.

Screening and Evaluation of Children’s Sensitively Toxic Chemicals in New Mosquito Repellent Products Based on a Nationwide Investigation

“…Some reports indicated that the use of NMRPs might be the main reason. 11,12 However, to the best of our knowledge, there is no study comprehensively recognizing toxic components and evaluating relative adverse consequences of NMRPs to date.…”

“…At the same time, however, dizziness, nausea, abdominal pain, and other safety incidents begin to be reported when children use NMRPs. Some reports indicated that the use of NMRPs might be the main reason. , However, to the best of our knowledge, there is no study comprehensively recognizing toxic components and evaluating relative adverse consequences of NMRPs to date.…”

Marching towards bioeconomy: Larvicidal effect of three indigenous plant extracts from Sri Lanka—Garcinia quaesita, Garcinia zeylanica, and Coleus hadiensis on dengue vector Aedes aegypti

“…Several groups of phytochemicals such as alkaloids, steroids, terpenoids, essential oils and phenolics from different plants have been reported previously for their insecticidal activities (Ghosh et al 2012). Development of plant-based insecticides and repellents has been focused by many recent studies (Maia & Moore 2011;Şengül Demirak & Canpolat 2022;Deng et al 2023;Priya et al 2023).…”

“…While being effective, the phytochemicals reduce the risk of potentially adverse ecological effects. Also, they may prevent the possibility of the resistance that synthetic chemical insecticides typically bring about after prolonged use (Monzon et al 1994;Priya et al 2023). Unlike conventional insecticides which are based on a single active ingredient, plant derived insecticides comprise botanical blends of chemical compounds which act concertedly on both behavioral and physiological processes.…”

In silico Screening of Plectranthus ampoinicus and Hyptis suaveolens Phytochemicals: Novel Repellents Targeting Odorant Binding Proteins of Aedes aegypti and Aedes albopictus

“…Mosquitoes are one of the main carriers of dangerous viruses that spread severe and fatal diseases worldwide (Edwin et al 2016;Priya et al 2023). Mosquitoes spread the greatest number of fatal diseases, including malaria, dengue, chikungunya, elephantiasis, and other arthropods (Priya et al 2023). Within the Culicidae family, Genus Aedes is known to pose a signi cant global public health threat.…”