Bioactive metabolites of Ganoderma lucidum: Factors, mechanism and broad spectrum therapeutic potential

Sharma, Chetan; Bhardwaj, Neha; Sharma, Abhishek; Tuli, Hardeep Singh; Batra, Priya; Beniwal, Vikas; Gupta, Girish Kumar; Sharma, Anil Kumar

doi:10.1016/j.hermed.2019.100268

Cited by 58 publications

(66 citation statements)

References 70 publications

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“…Briefly, the bioactive substances in the mushroom can be found in several of its parts, such as the mycelium and fruit body [4]. The most important types of these compounds are alkaloids, enzymes, glycoproteins, minerals, nucleotides, polysaccharides, proteins, steroids, triterpenes, and unsaturated fatty acids [39][40][41][42][43][44]. However, literature has reflected that the classification of the hydrophilic and hydrophobic properties of these compounds is useful to understand their effect as radioprotective compounds.…”

Section: Discussionmentioning

confidence: 99%

Use of Ganoderma lucidum (Ganodermataceae, Basidiomycota) as Radioprotector

et al. 2020

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For millennia, naturopaths and physicians have used Ganoderma lucidum (reishi mushroom) for its diverse therapeutic properties, as recorded in the oldest Chinese herbal encyclopedia. Indeed, a radioprotective effect has been reported in the isolated components of its extracts. A systematic review and meta-analyses (PRISMA) was conducted in March 2020, searching databases including PubMed, Scopus, Embase, and Google Scholar, along with Clinical Trials. The inclusion criteria were ex vivo, in vitro, and in vivo studies, with full texts in English, conducted to determine the radioprotective benefits of G. lucidum, or reports in which ionizing radiation was used. From a total number of 1109 records identified, 15 full text articles were eligible, none of them were clinical trials. In vivo studies reveal the efficiency of G. lucidum aqueous extracts of polysaccharides and triterpenes in mice exposed to γ-rays. In plasmid, they can reduce radiation damage as an increment of the open circular form, as well as increase the DNA extension, as shown in vitro studies. Ex vivo studies conducted in human blood cells show the radioprotective effect of β-glucan of aqueous extract of G. lucidum, nevertheless, its implementation as radioprotector to humans is in need of further clinical research studies.

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Section: Discussionmentioning

confidence: 99%

Use of Ganoderma lucidum (Ganodermataceae, Basidiomycota) as Radioprotector

et al. 2020

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“…Известно, что Ganoderma lucidum содержит тритерпены и полиглюканы. Во многих работах [6] было показано, что Ganoderma lucidum активирует лейкоциты через воздействие на Sialil-Lewis X модифицированный гликопротеин, вызывая стойкую адгезию к эндотелию через селектины (Е-селектин) [7][8][9][10]. Известно, что Ganoderma lucidum увеличивает экспрессию TNF и IL-1, в то же время эти цитокины индуцируют экспрессию эндотелиальными клетками лигандов к интегринам для VCAM 1 и ICAM 1.…”

Section: актуальностьunclassified

Prognostic Value of the Use of Ganoderma Lucidum Under Conditions of Oxidative Stress

Irsikulov¹,

Abilov²

2020

Medicina

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“…In addition, Ca, Fe, K, Mg, Na, P and Se amounts were 246.21, 109.42, 1345.07, 16.19, 6.46, 1662.06 and 2.47 mg/kg, respectively. Approximately 400 different bioactive compounds were reported in the fruiting bodies, mycelia, and spores of G. lucidum in various researches (Xu et al, 2011 a, b;Boh, 2013;Cör et al, 2018;Hapuarachchi et al, 2016aHapuarachchi et al, , 2018Sudheer et al, 2018;Sharma et al, 2019;Zhao et al, 2019). According to Karthikeyan et al (2009), Pekşen and Yakupoğlu (2009), and Turfan et al (2016), the differences in the chemical composition of wild and cultivated G. lucidum extracts were attributed to different sites of collection, quality of the strain, origin, cultivation conditions, stages of harvesting, and extraction processes of cultivated ones.…”

Section: Phytochemical Pharmacological Composition and Therapeutic Properties Of G Lucidummentioning

confidence: 99%

“…It was both considered as the "herb of spiritual potency" or "plant of immortality" that extended the lifetime because of its medicinal properties by Chinese people and symbolized sanctity, success, goodness, happiness, fortune, immortality, and good health in these countries (Paterson, 2006;Sanodiya et al, 2009;Wachtel-Galor et al, 2011;De Silva et al, 2012;Hapuarachchi et al, 2018;Sudheer et al, 2018). It was first indexed in Shen Nong's Materia Medica (206 BC-8 AD), known as the "Father of Chinese medicine", as a longevity promoting and tonic herb of the non-toxic superior class (Zhu et al, 2007;Sharma et al, 2019). It is currently listed in the American Herbal Pharmacopoeia, Chinese Pharmacopoeia and Therapeutic Compendium (Wu et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Health Benefits of Ganoderma lucidum as a Medicinal Mushroom

Bulam

Üstün

Pekşen

2019

Turkish JAF Sci.Tech.

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Ganoderma lucidum (Curtis) P. Karst., known as “Lingzhi” in China or “Reishi” in Japan, is a well-known medicinal mushroom and traditional Chinese medicine, which has been used for the prevention and treatment of bronchitis, allergies, hepatitis, immunological disorders and cancer. G. lucidum is rarely collected from nature and mostly cultivated on wood logs and sawdust in plastic bags or bottles to meet the demands of international markets. Diverse groups of chemical compounds with pharmacological activities, isolated from the mycelia and fruiting bodies of G. lucidum are triterpenoids, polysaccharides (β-D-glucans), proteins, amino acids, nucleosides, alkaloids, steroids, lactones, lectins, fatty acids, and enzymes. The biologically active compounds as primarily triterpenoids and polysaccharides of G. lucidum have been reported to possess hepatoprotective, antihypertensive, hypocholesterolemic, antihistaminic effects and antioxidant, antitumor, immunomodulatory, and antiangiogenic activities. Several formulations have been developed, patented and used as nutraceuticals, nutriceuticals and pharmaceuticals from G. lucidum’s water or ethanol extracts and rarely purified active compounds. As the result of clinical trials, various products have commercially become available as syrup, injection, tablet, tincture or bolus of powdered medicine and an ingredient or additive in dark chocolate bars and organic fermented medicinal mushroom drink mixes such as green teas, coffees, and hot cacaos. This review has intended to give and discuss recent knowledge on phytochemical and pharmacological compositions, therapeutic and side effects, clinical trials, and commercial products of G. lucidum.

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Bioactive metabolites of Ganoderma lucidum: Factors, mechanism and broad spectrum therapeutic potential

Cited by 58 publications

References 70 publications

Use of Ganoderma lucidum (Ganodermataceae, Basidiomycota) as Radioprotector

Use of Ganoderma lucidum (Ganodermataceae, Basidiomycota) as Radioprotector

Prognostic Value of the Use of Ganoderma Lucidum Under Conditions of Oxidative Stress

Health Benefits of Ganoderma lucidum as a Medicinal Mushroom

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