Bioactive Metabolites from Talaromyces purpureogenus, an Endophytic Fungus from Panax notoginseng

Feng, Li-Xi; Zhang, Bing-Yang; Zhu, Hua‐Jie; Pan, Li-Long; Cao, Fei

doi:10.1007/s10600-020-03206-9

Cited by 11 publications

(7 citation statements)

References 11 publications

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“…Compound 10 , C 11 H 10 O 4 , was a yellow powder: HR-ESI-MS m/z 207.0651 [M + H] + (calculated for C 11 H 11 O 4 + , 207.0652); 1 H-NMR (400 MHz, CD 3 OD, δ , ppm) δ H 6.39 ( 1 H, d, J = 1.5 Hz, H-7), 6.29 (1H, d, J = 1.5 Hz, H-5), 6.24 (1H, s, H-4), 3.78 (3H, s, H-10), and 2.10 (3H, s, H-9); and 13 C-NMR (100 MHz, CD 3 OD) δ C 165.1 (C, C-1), 163.6 123 (C, C-8), 158.3 (C, C-6), 155.0 (C, C-3), 142.2 (C, C-4a), 103.5 (CH, C-4), 102.9 (CH, C-5), 100.4 (C, C-8a), 99.2 (CH, C-7), 56.8 (CH 3 , C-10), and 19.4 (CH 3 , C-9). Compound 10 is 6-hydroxy-8-methoxy-3-methylisocoumarin [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

Polyketide Derivatives from the Endophytic Fungus Phaeosphaeria sp. LF5 Isolated from Huperzia serrata and Their Acetylcholinesterase Inhibitory Activities

Yang

Liang

Zhang

et al. 2022

JoF

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The secondary metabolites of Phaeosphaeria sp. LF5, an endophytic fungus with acetylcholinesterase (AChE) inhibitory activity isolated from Huperzia serrata, were investigated. Their structures and absolute configurations were elucidated by means of extensive spectroscopic data, including one- and two-dimensional nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) analyses, and calculations of electronic circular dichroism (ECD). A chemical study on the solid-cultured fungus LF5 resulted in 11 polyketide derivatives, which included three previously undescribed derivatives: aspilactonol I (4), 2-(1-hydroxyethyl)-6-methylisonicotinic acid (7), and 6,8-dihydroxy-3-(1′R, 2′R-dihydroxypropyl)-isocoumarin (9), and two new natural-source-derived aspilactonols (G, H) (2, 3). Moreover, the absolute configuration of de-O-methyldiaporthin (11) was identified for the first time. Compounds 4 and 11 exhibited inhibitory activity against AChE with half maximal inhibitory concentration (IC50) values of 6.26 and 21.18 µM, respectively. Aspilactonol I (4) is the first reported furanone AChE inhibitor (AChEI). The results indicated that Phaeosphaeria is a good source of polyketide derivatives. This study identified intriguing lead compounds for further research and development of new AChEIs.

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Section: Resultsmentioning

confidence: 99%

Polyketide Derivatives from the Endophytic Fungus Phaeosphaeria sp. LF5 Isolated from Huperzia serrata and Their Acetylcholinesterase Inhibitory Activities

Yang

Liang

Zhang

et al. 2022

JoF

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“…Compound 78 showed pronounced activity against B. subtilis (MIC, 1.56 µM). Compound 79 had a certain inhibitory activity against Micrococcus lysodeikticus (MIC = 0.73 µM) and Vibrio parahaemolyticus (MIC = 0.18 µM) [54].…”

Section: Talaromycesmentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. This has been more obvious during recent corona pandemics. Similarly, enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. In the present review, we reported 451 bioactive metabolites isolated from various groups of endophytic fungi from January 2015 to April 2021 along with their antibacterial profiling, chemical structures and mode of action. In addition, we also discussed various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi.

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“…Talaromyces purpureogenus (a teleomorph of the genus Penicillium), a red pigment producing lamentous fungus was isolated from both A. corniculatum and C. tagal. This species was reported as an endophyte from several terrestrial plants (Hu, 2019;Feng, 2020;Sharma, 2022) as well as sea weeds (Kumari, 2018). Our study is the rst report of endophytic T. purpureogenus from mangroves.…”

Section: Discussionmentioning

confidence: 55%

Diversity and bioactive profile of endophytic mycoflora in mangroves

Revathy

Mohan

Kesavan

et al. 2022

Preprint

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The present study deals with the mangrove associated endophytic fungi and their bioactivity profile. The fungal endophytes were isolated from the leaves of three mangrove species (Aegiceras corniculatum, Lumnitzera racemosa and Ceriops tagal) and identified by morphological and molecular methods (Internal Transcribed Spacer and β-tubulin (Ben A) sequencing). The isolates mainly belonged to Ascomycota (95%) and the Basidiomycota comprised only 5%. They come under 5 classes, 11 orders, 16 genera and 25 species. Under Ascomycota, four classes, viz., Sordariomycetes (44.5%), Eurotiomycetes (32.46%), Dothideomycetes (17.28%) and Saccharomycetes (1.83%) comprising 10 orders were recorded. Under Basidiomycota a single class viz., Agaricomycetes (3.93%) comprising 1 order (Agaricales) was observed. Colletotrichum (30.2%) was the dominant genus followed by Aspergillus (17.8%), Penicillium (14.1%), Phyllosticta (9.1%) etc. Penicillium citrinum was the dominant fungus (22%) in A. corniculatum; Colletotrichum siamense (31%) in L. racemosa and Aspergillus sydowii (35%) in C. tagal (Fig. 3). Among the isolates, the Colonization frequency (CF%) was maximum for Colletotrichum siamense (18%) followed by Phyllosticta capitalensis (11.6%). Penicillium citrinum was found in all the three plant species. Isolates from Ceriops tagal were found to exhibit higher antibacterial as well as hydrolytic enzyme production potential. Aspergillus montevidensis EF 30, Cladosporium oxysporum EF 316, Colletotrichum siamense EF 272, Penicillium chrysogenum EF 362, Colletotrichum fruticola EF 22, Ascotricha chartarum EF 374, Aspergillus sydowii EF 239, Talaromyces purpurogenus EF 313, Meyerozyma caribbica EF 347 and Schizophyllum commune EF 309 were segregated as potential strains for hydrolytic enzyme production. A. aculeatus EF 10, T. purpurogenus EF 313, C. oxysporum EF 316, C. fruticola EF 74, P. capitalensis EF 187, A. sydowi EF 226 and P. chrysogenum EF 363 showed notable antimicrobial property. T purprogenus EF 313 endowed with pigment (red) production has potential for application in dyeing industry. During the current study, 25 different species of endophytic fungal species could be recovered from three host mangrove plants and some of them were having high bioactive potential for possible commercial applications with respect to bioremediation and as antimicrobials in medicine and aquaculture.

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Bioactive Metabolites from Talaromyces purpureogenus, an Endophytic Fungus from Panax notoginseng

Cited by 11 publications

References 11 publications

Polyketide Derivatives from the Endophytic Fungus Phaeosphaeria sp. LF5 Isolated from Huperzia serrata and Their Acetylcholinesterase Inhibitory Activities

Polyketide Derivatives from the Endophytic Fungus Phaeosphaeria sp. LF5 Isolated from Huperzia serrata and Their Acetylcholinesterase Inhibitory Activities

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Diversity and bioactive profile of endophytic mycoflora in mangroves

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