Bioactive Materials: A Comprehensive Review on Interactions with Biological Microenvironment Based on the Immune Response

Nour, Shirin; Baheiraei, Nafiseh; Imani, Rana; Rabiee, Navid; Khodaei, Mohammad; Alizadeh, Akram; Moazzeni, Seyed Mohammad

doi:10.1007/s42235-019-0046-z

Cited by 40 publications

(35 citation statements)

References 108 publications

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“…Therefore, the greatest benefit of aptamers based on oligonucleotides over antibodies based on proteins is their constant properties at high temperatures, even after a 95°C denaturation. [10][11][12][13] Aptamers are minimally toxic molecules with low immunogenicity because nucleic acids usually are not recognized as an external, foreign agent by the human immune system. 14,15 Aptamers are derived from SELEX (Systematic Evolution of Ligands by Exponential Enrichment) or in vitro evolutionary processes, so toxins and other molecules that do not induce a strong immune response can be used as the object to develop aptamers.…”

Section: Introductionmentioning

confidence: 99%

Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review

Rabiee¹,

Ahmadi²,

Arab³

et al. 2020

IJN

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With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, as a new exciting approach for cancer treatment in the decades ahead to meet our growing societal needs.

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Section: Introductionmentioning

confidence: 99%

Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review

Rabiee¹,

Ahmadi²,

Arab³

et al. 2020

IJN

Self Cite

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show abstract

“…As a major process in the developmental process and also wound healing, angiogenesis is assisted by complex interactions and cross‐talks, which are activated by several genes through different signaling pathways including HIF, 16,18,19 Sonic Hedgehog (Shh), 20‐23 and inflammatory pathways 24 as summarized in Figure 1. In addition to the expression of angiogenic growth factors, these signaling pathways pave the way for the proceeding healthy angiogenesis process, controlling the expression of growth factors, arteriogenesis, and transition of small arteries to large ones that is essential in the improvement of blood circulation around chronic wounds 27,28 …”

Section: Angiogenesis During Wound Healingmentioning

confidence: 99%

Skin wound healing assisted by angiogenic targeted tissue engineering: A comprehensive review of bioengineered approaches

Nour

Imani

Chaudhry

et al. 2020

J Biomedical Materials Res

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Skin injuries and in particular, chronic wounds, are one of the major prevalent medical problems, worldwide. Due to the pivotal role of angiogenesis in tissue regeneration, impaired angiogenesis can cause several complications during the wound healing process and skin regeneration. Therefore, induction or promotion of angiogenesis can be considered as a promising approach to accelerate wound healing. This article presents a comprehensive overview of current and emerging angiogenesis induction methods applied in several studies for skin regeneration, which are classified into the cell, growth factor, scaffold, and biological/chemical compound‐based strategies. In addition, the advantages and disadvantages of these angiogenic strategies along with related research examples are discussed in order to demonstrate their potential in the treatment of wounds.

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“…For example, heart failure is due to the inability of the heart to pump blood and the adult heart muscle is incapable of regenerating damaged myocardial tissue which becomes replaced with non-contacting scar tissue. [1][2][3][4][5][6][7][8] Currently, no standard clinical procedure is available to restore the damaged myocardium other than complete heart transplantation and pharmaceutical drugs that thin blood, making it easier to pump by a failing heart. Thus, there is an urgent demand to develop new methods to repair damaged cardiac tissue.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine

Nasr¹,

Rabiee²,

Hajebi³

et al. 2020

IJN

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Cardiovascular diseases are the number one cause of heart failure and death in the world, and the transplantation of the heart is an effective and viable choice for treatment despite presenting many disadvantages (most notably, transplant heart availability). To overcome this problem, cardiac tissue engineering is considered a promising approach by using implantable artificial blood vessels, injectable gels, and cardiac patches (to name a few) made from biodegradable polymers. Biodegradable polymers are classified into two main categories: natural and synthetic polymers. Natural biodegradable polymers have some distinct advantages such as biodegradability, abundant availability, and renewability but have some significant drawbacks such as rapid degradation, insufficient electrical conductivity, immunological reaction, and poor mechanical properties for cardiac tissue engineering. Synthetic biodegradable polymers have some advantages such as strong mechanical properties, controlled structure, great processing flexibility, and usually no immunological concerns; however, they have some drawbacks such as a lack of cell attachment and possible low biocompatibility. Some applications have combined the best of both and exciting new natural/ synthetic composites have been utilized. Recently, the use of nanostructured polymers and polymer nanocomposites has revolutionized the field of cardiac tissue engineering due to their enhanced mechanical, electrical, and surface properties promoting tissue growth. In this review, recent research on the use of biodegradable natural/synthetic nanocomposite polymers in cardiac tissue engineering is presented with forward looking thoughts provided for what is needed for the field to mature.

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Bioactive Materials: A Comprehensive Review on Interactions with Biological Microenvironment Based on the Immune Response

Cited by 40 publications

References 108 publications

<p>Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review</p>

<p>Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review</p>

Skin wound healing assisted by angiogenic targeted tissue engineering: A comprehensive review of bioengineered approaches

<p>Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine</p>

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