Bioactive Indole Alkaloids from the Bark of<i>Uncaria guianensis</i>

Lee, Kit K.; Bin, Zhou; Kingston, David G. I.; Vaisberg, Abraham J.; Hammond, Gerald B.

doi:10.1055/s-2006-960860

Cited by 39 publications

(19 citation statements)

References 2 publications

(2 reference statements)

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“…In addition, cat's claw has been reported to induce a lymphocyte-proliferation-regulating factor in endothelian cells [156]. There are few scientific publications concerning U. guianensis, and those which exist provide evidence only for its quinovic acid glycoside and alkaloid content [157,158]. However, U. guianensis is used in traditional medicine in tropical South America for the treatment of arthritis and as an anti-inflammatory agent [159].…”

Section: Natural Antioxidantsmentioning

confidence: 99%

Antioxidants and Inflammatory Disease: Synthetic and Natural Antioxidants with Anti-Inflammatory Activity

Geronikaki

Gavalas

2006

CCHTS

212

140

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Oxidants play a significant role in the pathogenesis of a number of disorders such as inflammation, rheumatoid arthritis, asthma, psoriasis and contact dermatitis leading to oxidative stress. Oxidative stress may be defined as an imbalance between cellular production of reactive oxygen species (ROS) and antioxidant defense mechanisms. ROS (e.g., superoxide radical, peroxynitryl, hydroxyl radical and hydrogen peroxide) are constantly produced as a result of metabolic reactions in living systems. The aim of this review is to describe recent developments in the study of antioxidants and their role in preventing the formation of ROS. The processes associated with inflammatory responses are complex and often involve ROS. There are many mediators, which initiate and amplify the inflammatory response such as histamine, serotonin, pro-inflammatory cytokines (interleukin-1B (IL-1b) and tumor necrosis factor (TNF-alpha), inflammatory cells (leukotrienes, macrophages), metabolic products of arachidonic acid (thomboxane A(2), prostaglandins and leukotrienes). The first part of this review focuses on the role of ROS in inflammation. The second part concerns synthetic antioxidants with antiinflammatory activity, and the third part addresses naturally occurring antioxidants with antiinflammatory activity.

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Section: Natural Antioxidantsmentioning

confidence: 99%

Antioxidants and Inflammatory Disease: Synthetic and Natural Antioxidants with Anti-Inflammatory Activity

Geronikaki

Gavalas

2006

CCHTS

212

140

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“…Plant species from the Cordillera Blanca, one of the highaltitude areas of Peru, have been studied in recent years for their antimicrobial, anti-cancer, and wound-healing activities (Bussmann et al 2008, Hammond et al 1998, Lee et al 1999, Neto et al 2002, Villegas et al 1997 …”

Section: Introductionmentioning

confidence: 99%

Proving that Traditional Knowledge Works: The antibacterial activity of Northern Peruvian medicinal plants

Bussmann¹,

Glenn²,

Sharon³

et al. 2011

Ethnobot. Res. App.

371

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had a much lower efficacy against bacteria and fell within the range of species that are traditionally used to treat other bodily disorders. ResumenInfecciones bacterianas e inflamación se encuentran entre las enfermedades tratadas por curanderos tradicionales. La Organización Mundial de Salud se ha expresada como altamente interesada en la Medicina Tradicional, y es importante demostrar cientí-ficamente que los remedios usados en la medicina The aim of the study was to scientifically test whether plants used in TM for the treatment of infections showed antibacterial activity, and to delineate a number of candidates for further in-depth study of their Minimum Inhibitory Concentration (MIC) and toxicity. One-hundred-ninety-three ethanolic extracts and 31 water extracts were active against S. aureus. In twentyone cases only the water extract showed activity. None of the aqueous extracts were active against the other three bacteria, with the activity of the ethanolic extracts also much reduced, as only 36 showed any activity against E. coli, and 3 each against S. enterica Typhi and P. aeruginosa. Two-hundred-twenty-five extracts came from species that are traditionally employed against bacterial infections. One-hundred-sixty-six (73.8%) of these were active against at least one bacterium. Of the three-hundred extracts from plants without traditional antibacterial use, only 96 (32%) showed any activity Plants used for respiratory disorders, inflammation/infection, wounds, diarrhea, and to prevent post partum infections were efficacious in 70-88% of the tests. Plants used for "kidney inflammation"Published: February 25, 2011

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“…12,15 Bioassay-guided fractionation of the EtOH extract of U. guianensis bark using a yeast-based assay for DNA-damaging agents lead to two weakly but selectively active oxindole alkaloids. 16 The EtOH extract of the leaves of U. guianensis showed anti-inflammatory and anti-allergic activities. 17 The present work describes the isolation of kaempferol-3,7-O-(α)-dirhamnoside (kaempferitrin) from the leaves of U. guianensis and the screening for this compound in the EtOH extracts from the leaves, stems or bark of U. guianensis and U. tomentosa through TLC and HPLC-DAD-MS techniques.…”

Section: Introductionmentioning

confidence: 99%

Kaempferitrin from Uncaria guianensis (Rubiaceae) and its potential as a chemical marker for the species

Valente¹,

Bizarri²,

Liechocki³

et al. 2009

J. Braz. Chem. Soc.

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Uncaria tomentosa (Willd.) DC. e U. guianensis (Aubl.) Gmel., conhecidas como unha-de-gato, são trepadeiras lenhosas nativas das florestas tropicais amazônica e central-americana. As espécies contêm, em diferentes proporções, alcalóides indólicos e oxindólicos, triterpenóides glicosilados, esteróides e proantocianidinas. U. tomentosa é quimicamente identificada pelo perfil e conteúdo de alcalóides oxindólicos, ao passo que U. guianensis não possui um marcador químico efetivo. Nesse trabalho descreve-se o isolamento de canferol-3,7-O-(α)-dirramnosídeo (canferitrina) pela primeira vez em espécies do gênero Uncaria. A triagem para essa substância em folhas, galhos ou cascas das duas espécies por CCD e CLAE-DAD-EM demonstrou a presença de canferitrina apenas nas folhas e galhos de U. guianensis, numa proporção cerca de trinta e seis vezes maior nas folhas do que nos galhos. Estes resultados revelaram a seletividade da U. guianensis em produzir o flavonóide glicosilado, sugerindo esta substância como um marcador químico potencial para a espécie.Uncaria tomentosa (Willd.) DC. and U. guianensis (Aubl.) Gmel., known as cat's claw, are large woody vines native to the Amazonian and Central American rainforests. The species contain, in different proportions, indole and oxindole alkaloids, triterpenoid glycosides, sterols and proanthocyanidins. U. tomentosa can be chemically identified by its oxindole alkaloid profile and content, whereas U. guianensis has no satisfactorily established chemical markers. This work describes, for the first time, the isolation of kaempferol-3,7-O-(α)-dirhamnoside (kaempferitrin) in Uncaria species. Screening for this compound in leaves, stems or bark of both species through TLC and HPLC-DAD-MS showed the presence of kaempferitrin only in the leaves and stems of U. guianensis, at a ratio almost thirty six times greater in the leaves than in the stems. These results reveal the selectivity of U. guianensis to produce this bioactive flavonoid glycoside, and suggest this compound as a potential chemical marker for the species.

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Bioactive Indole Alkaloids from the Bark ofUncaria guianensis

Cited by 39 publications

References 2 publications

Antioxidants and Inflammatory Disease: Synthetic and Natural Antioxidants with Anti-Inflammatory Activity

Antioxidants and Inflammatory Disease: Synthetic and Natural Antioxidants with Anti-Inflammatory Activity

Proving that Traditional Knowledge Works: The antibacterial activity of Northern Peruvian medicinal plants

Kaempferitrin from Uncaria guianensis (Rubiaceae) and its potential as a chemical marker for the species

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