Bioactive p-Terphenyl Derivatives from a Cordyceps-Colonizing Isolate of Gliocladium sp.

Guo, Huijuan; Hu, Hejiao; Liu, Shuchun; Liu, Xingzhong; Zhou, Yu‐Guang; Che, Yongsheng

doi:10.1021/np070231k

Cited by 64 publications

(39 citation statements)

References 14 publications

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“…[2] Even though many medical benefits, including antitumor activity, have been reported for this fungus, [3] whether the active components are produced by C. sinensis or its colonizing fungi remains to be investigated. During an ongoing search for new bioactive natural products from the Cordyceps-colonizing isolates, [4,5] the fungus Trichocladium opacum (X116), isolated from a sample of C. sinensis collected in Linzhi, Tibet, P. R. China, was grown in a solid-substrate fermentation culture. The extract in organic solvent displayed cytotoxicity against two human tumor cell lines, HeLa and MCF-7.…”

Section: Introductionmentioning

confidence: 99%

“…[24] Massarigenin A (4): The 1 H NMR, 13 C NMR, and ESIMS data were fully consistent with literature values. [6] MTT Assay: [4] In 96-well plates, 10 4 cells were introduced into each well. After cell attachment overnight, the medium was removed and each well was treated with 50 µL of medium containing 0.2 % DMSO or the appropriate concentration of test compounds (10 mg mL -1 as the stock solution of the compound in DMSO and serial dilutions).…”

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confidence: 99%

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Trichocladinols A–C, Cytotoxic Metabolites from a Cordyceps‐Colonizing Ascomycete Trichocladium opacum

et al. 2009

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Trichocladinols A–C (1–3), three new metabolites, and the known massarigenin A (4), have been isolated from cultures of a Cordyceps‐colonizing ascomycete Trichocladium opacum. Their structures were elucidated by NMR spectroscopy and X‐ray crystallography. The absolute configuration of 1 was assigned by using the modified Mosher method and that of 3 was determined by X‐ray crystallographic analysis of its (S)‐MTPA ester. Compounds 1–3 showed modest cytotoxic effects against the human tumor cell lines HeLa and MCF‐7. Structurally, compounds 1 and 2 possess a previously undescribed 2,9‐dioxatricyclo[5.2.1.03,8]dec‐4‐ene skeleton.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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Trichocladinols A–C, Cytotoxic Metabolites from a Cordyceps‐Colonizing Ascomycete Trichocladium opacum

et al. 2009

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“…After evaporation of the aqueous layer, 1.0 mg of L-cysteine methyl ester hydrochloride and 100 µL of pyridine were added, and the mixture was stirred at 60°C for 1 h. o-Tolylisothiocyanate (100 µL) was added, and the solution was stirred at 60°C for another 1 h. The reaction mixture was directly analyzed by RP HPLC (Kromasil 100-5 C 18 column; 4.6 × 250 mm; 25% CH 3 In a similar fashion, a sample of 4 (3.0 mg, 0.015 mmol), CH 2 Cl 2 (3.0 mL), DMAP (8.0 mg), and (R)-MTPACl (5.0 µL, 0.026 mmol) were allowed to react in a 10 mL round-bottomed flask at room temperature for 12 h, and the reaction mixture was processed as described above for 4a to afford 4b (1.0 mg): colorless oil; 1 H NMR (acetone-d 6 , 400 MHz) δ 7.38 (2H, d, J ) 8.4 Hz, H-3/H-7 MTT Assay. 23 The assay was run in triplicate. In 96-well plates, each well was plated with 10 4 cells.…”

Section: Resultsmentioning

confidence: 99%

Allenyl and Alkynyl Phenyl Ethers from the Endolichenic Fungus Neurospora terricola

Zhang¹,

Liu²,

Lu³

et al. 2009

J. Nat. Prod.

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Terricollenes A−C (1−3), new allenyl phenyl ethers, and terricolynes (4−6), new alkynyl phenyl ethers, have been isolated from the crude extract of the endolichenic fungus Neurospora terricola. The structures of these compounds were elucidated primarily by NMR experiments. The absolute configurations of 1 and 2 were determined by reversed-phase HPLC analysis on the o-tolylthiocarbamates of the liberated sugars upon acid hydrolysis, whereas that of 4 was assigned using the modified Mosher method. Compound 1 showed modest cytotoxicity against the human tumor cell lines HeLa and MCF-7.

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“…Except for the 22 fungal species reported to be associated with natural Chinese cordyceps during the 1980s and 1990s (Jiang and Yao 2002), mycoflora investigation indicated the richness of fungal diversity on Chinese cordyceps based on culture-dependent and culture-independent methods (Zhang et al 2010). Many new novel secondary metabolites have been identified from the cordyceps-colonizing fungi (Zhang et al 2007, 2009; Guo et al 2007; Guo, Sun, Gao, Chen, et al 2009; Guo, Sun, Gao, Niu, et al 2009; Ma et al 2011). There is no doubt that the cordyceps-colonizing fungi are important resources for the discovery of novel compounds and for developing medicinal and healthy products.…”

Section: Perspectivementioning

confidence: 99%

Cordyceps industry in China

Dong

Guo²,

Wang

et al. 2015

Mycology

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Cordyceps, as a general term, describes a group of ascomycetous fungi growing on arthropods and other related fungi. Some cordyceps have been used in traditional Chinese medicine for centuries and cordyceps-derived products are currently a big industry in China. A number of medicinal and health products have been developed and extensively commercialized from natural Chinese cordyceps, its anamorphic fungus (Hirsutella sinensis), and other fungi known as Chinese cordyceps. The lack of a defined classification system for medicinal cordyceps fungi is a source of confusion in the industry and the public, and even among pharmaceutical scientists. This review summarizes the cordyceps fungi currently used in the industry in China with a special reference to clarify Chinese cordyceps and associated fungi. Cordyceps militaris, Cordyceps guangdongensis and Isaria cicadae are well recognized and commercialized cordyceps fungi in China. Except the natural Chinese cordyceps and its anamorphic fungus, Paecilomyces hepiali, Mortierella hepiali, Cephalosporium sinensis and Clonostachys rosea isolated from natural Chinese cordyceps are classified as Chinese cordyceps–associated fungi. P. hepiali is a cordyceps fungus based on current phylogenetic analysis of Hypocreales, while M. hepiali is a fungus in the Zygomycetes and should only be treated as associated fungus of Chinese cordyceps. C. sinensis and C. rosea belong to the Hypocreales and their relationship to cordyceps fungi should be further studied. The exploitation of the resources of cordyceps fungi and their quality control in the industry should be major topics for future studies. Cooperation between the industry and the research community will enhance the whole cordyceps industry.

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Bioactive p-Terphenyl Derivatives from a Cordyceps-Colonizing Isolate of Gliocladium sp.

Cited by 64 publications

References 14 publications

Trichocladinols A–C, Cytotoxic Metabolites from a Cordyceps‐Colonizing Ascomycete Trichocladium opacum

Trichocladinols A–C, Cytotoxic Metabolites from a Cordyceps‐Colonizing Ascomycete Trichocladium opacum

Allenyl and Alkynyl Phenyl Ethers from the Endolichenic Fungus Neurospora terricola

Cordyceps industry in China

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