Abstract:Novel bioactive organic-inorganic hybrid materials that can serve as injectable hydrogel systems for bone tissue regeneration were obtained. The silica nanoparticles (SiNP) prepared in situ by the Stöber method were dispersed in collagen, collagen-chitosan or chitosan sols, which were then subsequently crosslinked. Laser scanning confocal microscopy studies, in which fluorescent SiNP were applied, and SEM images indicated that the nanosilica particles were distributed in the whole volume of the hydrogel matrix… Show more
“…Other inorganic materials such as nanosilica and Bioglass have been studied for the preparation of hybrid hydrogel systems. 288,289 For example, Vishnu Priya et al 290 have developed an injectable hydrogel system by using chitin and poly(butylene succinate) loaded with fibrin nanoparticles and magnesium-doped Bioglass. This hydrogel system enhances the initiation of differentiation and expression of alkaline phosphatase and osteocalcin, thus indicating its promise for regenerating irregular bone defects.…”
Section: Injectable Hydrogels For Bone Tissue Engineeringmentioning
Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix (ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.
“…Other inorganic materials such as nanosilica and Bioglass have been studied for the preparation of hybrid hydrogel systems. 288,289 For example, Vishnu Priya et al 290 have developed an injectable hydrogel system by using chitin and poly(butylene succinate) loaded with fibrin nanoparticles and magnesium-doped Bioglass. This hydrogel system enhances the initiation of differentiation and expression of alkaline phosphatase and osteocalcin, thus indicating its promise for regenerating irregular bone defects.…”
Section: Injectable Hydrogels For Bone Tissue Engineeringmentioning
Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix (ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.
“…This is an alternative strategy to highly crosslinked hydrogels which are generally stiff materials with limited extensibility, poor swelling capability as well as slow molecular diffusion . Therefore, with the aim of designing CS hydrogels with excellent mechanical strength and high elasticity for tissue engineering and drug delivery applications, a large variety of inorganic NPs have been incorporated into hydrogels, such as silica NPs, metal NPs, hydroxyapatite (HAp) NPs, graphene oxide (GO) NPs and clay NPs . Han and Yan exploited the multifunctional groups of GO NPs to prepare supramolecular hydrogels of CS .…”
Chitosan (CS) has received much attention as a functional biopolymer for designing various hydrogels for biomedical applications. This review provides an overview of the different types of CS-based hydrogels, the approaches that can be used to fabricate hydrogel matrices with specific features and their applications in controlled drug delivery and tissue engineering. Emphasis is laid on the recent design concepts of hybrid hydrogels based on mixtures of CS and natural or synthetic polymers, interpenetrating polymer networks as well as composite hydrogels prepared by embedding nanoparticles into CS matrices.
“…The biosilica spicules are embedded into an organic matrix and it has been demonstrated that they are nontoxic for mammalian cells, already suggesting their biocompatibility . Indeed, biosilica derived from marine sponges is being considered for biomedical approaches, bone replacement and regeneration strategies in TE, specially because silica ions are known as an important element to stimulate bone formation . Bioactive silica glasses, for instance, bond and integrate to bone tissue through the formation of a silica gel layer, which attracts and stimulate osteoprogenitor cells to proliferate and to differentiate in osteoblasts, starting the synthesis and the deposition of bone organic matrix and matrix mineralization …”
Section: Sponges Composition: Interesting Elements For Bone Tissue Enmentioning
confidence: 99%
“…42 Indeed, biosilica derived from marine sponges is being considered for biomedical approaches, bone replacement and regeneration strategies in TE, 33 specially because silica ions are known as an important element to stimulate bone formation. [44][45][46] Bioactive silica glasses, for instance, bond and integrate to bone tissue through the formation of a silica gel layer, which attracts and stimulate osteoprogenitor cells to proliferate and to differentiate in osteoblasts, starting the synthesis and the deposition of bone organic matrix and matrix mineralization. 12,14 In this context, some authors have performed in vitro studies to verify the biocompatibility of biosilica derived from marine sponges.…”
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