Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional Chinese medicines

Xu, Tengfei; Liu, Shu; Meng, Lulu; Pi, Zifeng; Song, Fengrui; Liu, Zhiqiang

doi:10.1016/j.jchromb.2015.09.023

Cited by 9 publications

(3 citation statements)

References 98 publications

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“…Aconitum plants chemically comprise alkaloids, flavonoids, steroids, and glycosides, and the main efficacy components as well as the toxic components are diterpenoid alkaloids [21,22,23], which are reportedly some of the most promising, naturally abundant compounds for treating cancer [24]. Diterpenoid alkaloids have been studied since the 1940s, and based on structural differences such as the number of carbon atoms on the mother nucleus, diterpenoid alkaloids are generally divided into four categories: C 18 -, C 19 -, C 20 -, and bis-diterpenoid alkaloids [25,26,27,28,29].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activities of C18-, C19-, C20-, and Bis-Diterpenoid Alkaloids Derived from Genus Aconitum

Ren

Shi

et al. 2017

Molecules

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Cancer is one of the most common lethal diseases, and natural products have been extensively studied as anticancer agents considering their availability, low toxicity, and economic affordability. Plants belonging to the genus Aconitum have been widely used medically in many Asian countries since ancient times. These plants have been proven effective for treating several types of cancer, such as lung, stomach, and liver cancers. The main effective components of Aconitum plants are diterpenoid alkaloids—which are divided into C18-, C19-, C20-, and bis-diterpenoid alkaloids—are reportedly some of the most promising, naturally abundant compounds for treating cancer. This review focuses on the progress of diterpenoid alkaloids with different structures derived from Aconitum plants and some of their derivatives with potential anticancer activities. We hope that this work can serve as a reference for further developing Aconitum diterpenoid alkaloids as anticancer agents.

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Section: Introductionmentioning

confidence: 99%

Anticancer Activities of C18-, C19-, C20-, and Bis-Diterpenoid Alkaloids Derived from Genus Aconitum

Ren

Shi

et al. 2017

Molecules

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“…Pharmacological studies have indicated that many diterpenoid alkaloids are important chemical constituents of this herbal remedies with analgesic, anti-cancer, anti-inflammatory, and anti-arrhythmic activities [ 1 ]. The anti-inflammatory activity was the first confirmed important pharmacological activity of the diterpenoid alkaloids, and is stronger than that of many active anti-inflammatory drugs [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although diterpenoid alkaloids are toxic, they have significant pharmacological activities. Diterpenoid alkaloids interact with receptors in the neurotransmitter systems and have electrophysiological properties, therefore are the good candidates to develop drugs with anti-inflammatory activity [ 2 ]. The relationship between the structure and activity is determined by the structure-activity relationship, in order to modify the structure of the compounds and enhance the anti-inflammatory activity [ 2 ], hence we studied the relationship between the activity and structure of the diterpenoid alkaloids.…”

Section: Introductionmentioning

confidence: 99%

An Investigation on the Quantitative Structure-Activity Relationships of the Anti-Inflammatory Activity of Diterpenoid Alkaloids

Xiao

Sui

et al. 2017

Molecules

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Diterpenoid alkaloids are extracted from plants. These compounds have broad biological activities, including effects on the cardiovascular system, anti-inflammatory and analgesic actions, and anti-tumor activity. The anti-inflammatory activity was determined by carrageenan-induced rat paw edema and experimental trauma in rats. The number of studies focused on the determination, quantitation and pharmacological properties of these alkaloids has increased dramatically during the past few years. In this work we built a dataset composed of 15 diterpenoid alkaloid compounds with diverse structures, of which 11 compounds were included in the training set and the remaining compounds were included in the test set. The quantitative chemistry parameters of the 15 diterpenoid alkaloids compound were calculated using the HyperChem software, and the quantitative structure–activity relationship (QSAR) of these diterpenoid alkaloid compounds were assessed in an anti-inflammation model based on half maximal effective concentration (EC50) measurements obtained from rat paw edema data. The QSAR prediction model is as follows: log(EC50)=−0.0260×SAA+0.0086×SAG+0.0011×VOL−0.0641×HE−0.2628×LogP−0.5594×REF−0.2211×POL−0.1964×MASS+0.088×BE+0.1398×HF (R2 = 0.981, Q2 = 0.92). The validated consensus EC50 for the QSAR model, developed from the rat paw edema anti-inflammation model used in this study, indicate that this model was capable of effective prediction and can be used as a reliable computational predictor of diterpenoid alkaloid activity.

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Diterpenoid trigonoreidon B isolated from Trigonostemon reidioides alleviates inflammation in models of LPS-stimulated murine macrophages and inflammatory liver injury in mice

Utaipan

Suksamrarn

Kaemchantuek

et al. 2018

Biomedicine & Pharmacotherapy

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Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional Chinese medicines

Cited by 9 publications

References 98 publications

Anticancer Activities of C18-, C19-, C20-, and Bis-Diterpenoid Alkaloids Derived from Genus Aconitum

Anticancer Activities of C18-, C19-, C20-, and Bis-Diterpenoid Alkaloids Derived from Genus Aconitum

An Investigation on the Quantitative Structure-Activity Relationships of the Anti-Inflammatory Activity of Diterpenoid Alkaloids

Diterpenoid trigonoreidon B isolated from Trigonostemon reidioides alleviates inflammation in models of LPS-stimulated murine macrophages and inflammatory liver injury in mice

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