Bioactive Glasses—Structure and Properties

Brauer, Delia S.

doi:10.1002/anie.201405310

Cited by 325 publications

(275 citation statements)

References 216 publications

(426 reference statements)

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“…But only a few works have been published about structural studies performed directly on the fibres due to the complexity of their determination [7]. More recently, several works have been published on the improvement of processing conditions for fibre drawing based on kinetic fragility determination [10,11], enhancing the important role of the structure to predict the behaviour of bioactive glasses during processing [12].…”

Section: Introductionmentioning

confidence: 99%

Structure–properties relationships in fibre drawing of bioactive phosphate glasses

et al. 2017

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New bioactive phosphate glasses suitable for continuous fibre production are investigated in this work. The structure of both bulk and fibres from Na 2 O-CaO-MgO-P 2 O 5 glasses has been studied by means of Raman and 31 P and 23 Na Nuclear Magnetic Resonance spectroscopies, and the structural results have been correlated with the mechanical properties of the fibres and the dissolution rate of the bulk glasses. It has been observed that the mechanical properties of the phosphate glass fibres are influenced by the glass network connectivity, whilst the dissolution rates are governed by the Q i speciation of the PO 4 units. As seen in previous studies, molar volume seems to play an important role in the fragility behaviour of phosphate glasses. Here, a lower molar volume resulting from the increase in the oxygen packing density, hinders the cooperative flow of the PO 4 units throughout the glass network and, therefore, causes a reduction in the kinetic fragility.

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Section: Introductionmentioning

confidence: 99%

Structure–properties relationships in fibre drawing of bioactive phosphate glasses

et al. 2017

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“…It is known that the composition and structure are critical for their bioactivity 3 to PA-BG, whose surface was entirely covered by HA after 24h (figure 5c), the surfaces of these two samples were only partially covered by HA after 24h (figure 5f, 5i).…”

Section: In Vitro Assay In Sbfmentioning

confidence: 99%

The influence of phosphorus precursor on the structure and properties of SiO ₂ –P ₂ O ₅ –CaO bioactive glass

Ren

et al. 2017

Biomed. Phys. Eng. Express

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Bioactive glasses (BG) are one of the most promising bone regeneration materials because they can bond to bone and simulate new bone growth. Sol-gel methods for producing BG are well established, however challenges still remain in selecting and optimizing the precursors. Even for bioactive glasses with the same final composition, different precursors may lead to different structures and properties of the gel derived BG. In this work, three different phosphorus precursors, phytic acid (PA), triethyl phosphate (TEP) and n-butyl phosphate (BP) were used to prepare BG (54.2%SiO2-35%CaO-10.8%P2O5, mol. %). The obtained materials were characterized by TGA, FTIR, XRD, HEXRD, solid state 31 P, 29 Si NMR and by in vitro tests in SBF. It was found that the materials prepared by TEP or BP showed small amounts of crystallization, whereas the resulting material prepared by PA remained amorphous and had more P atoms as orthophosphate. In vitro assays indicated that all these materials were bioactive, while the BG prepared by PA showed the highest in vitro bioactivity, followed by TEP and, finally, BP. Based on these observations, it appears that phosphorus precursors have a significant impact on both the structure and bioactivity of the sol-gel derived BG. Results suggest that phytic acid should be used in preference to triethyl phosphate or n-butyl phosphate for the synthesis of sol gels. PA may improve the homogeneity of the sol gel glasses, reduce crystallization and lower stabilization temperatures.

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“…With time, the intensity of the peaks increased and a second peak appeared after 14 days which had an increased intensity at 21 days. This may be due to ion-exchange and/or ion-insertion in the crystal structure and hence apatite formation [9,31].…”

Section: Bioactivity Of Bioactive Glass Particulatementioning

confidence: 99%

“…tion of stem cells without any additional chemical supplements [20,33,35]. This is mainly due to their degradation capability which liberates ions such as Ca, P, Si, Na, Sr etc [9,11,16,36] depending upon their initial chemical composition of the glass. Often, sol-gel derived BG structures have a greater bioactivity than melt-derived ones and this is mainly due to a greater surface area, inherent nanoporosity and higher levels of OH on the surface of glass [37].…”

Section: Figurementioning

confidence: 99%

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Long term effects of bioactive glass particulates on dental pulp stem cells in vitro

Gholami¹,

Labbaf²,

Houreh³

et al. 2017

Biomedical Glasses

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Bioactive glasses (BG) are known for their ability to induce bone formation by the action of their dissolution products. Glasses can deliver active ions at a sustained rate, determined by their composition and surface area. Nanoporous sol-gel derived BGs can biodegrade rapidly, which can lead to a detrimental burst release of ions and a pH rise. The addition of phosphate into the glass can buffer the pH during dissolution. Here, dissolution of BG with composition 60 mol% SiO 2 , 28 mol% CaO and 12 mol% P 2 O 5 at 600 µg/ml were investigated. Initially, the dissolution and apatite formation of the BG particulates were examined in simulated body fluid using FTIR and XRD. BG particulates were indirectly exposed to dental pulp stem cells, and the effect of 14 days continuous ion release on human dental pulp stem cells (hDPSC) viability and differentiation was evaluated. Alamar blue assay showed that cell proliferation was not inhibited by the continuous release of Ca, P and soluble silica. In fact, hDPSC in the presence of BG particulate displayed a higher density of mineralized nodules than untreated cells, as assessed by Alizarin red. The results will have a great contribution to the in vivo application of this particular BG.

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Bioactive Glasses—Structure and Properties

Cited by 325 publications

References 216 publications

Structure–properties relationships in fibre drawing of bioactive phosphate glasses

Structure–properties relationships in fibre drawing of bioactive phosphate glasses

The influence of phosphorus precursor on the structure and properties of SiO ₂ –P ₂ O ₅ –CaO bioactive glass

Long term effects of bioactive glass particulates on dental pulp stem cells in vitro

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Bioactive Glasses—Structure and Properties

Cited by 325 publications

References 216 publications

Structure–properties relationships in fibre drawing of bioactive phosphate glasses

Structure–properties relationships in fibre drawing of bioactive phosphate glasses

The influence of phosphorus precursor on the structure and properties of SiO 2 –P 2 O 5 –CaO bioactive glass

Long term effects of bioactive glass particulates on dental pulp stem cells in vitro

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The influence of phosphorus precursor on the structure and properties of SiO ₂ –P ₂ O ₅ –CaO bioactive glass