Bioactive glass with biocompatible polymers for bone applications

Sonatkar, Janhavi; Kandasubramanian, Balasubramanian

doi:10.1016/j.eurpolymj.2021.110801

Cited by 25 publications

(11 citation statements)

References 204 publications

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“…The other fraction is organic, predominately composed of type I collagen, but proteins such as proteoglycans and glycoproteins are also present. The tissue morphology is also heterogenous as it consists of some compact/dense regions (cortical bone) and other porous/spongy (trabecular bone) regions [ 1 , 38 , 39 ].…”

Section: Bone Engineeringmentioning

confidence: 99%

Section: Bioactive Glasses (Bgs)mentioning

confidence: 99%

“…Composites based on gelatin and bioactive glass (BG) with different morphologies and compositions have been designed to assist in the treatment of tissue injuries, aiming at the aesthetic and functional recovery of damaged limbs [ 1 , 2 ]. In general, these materials must be biocompatible and/or biodegradable, have mechanical strength comparable to that of the host tissue, and allow cellular activity at the implant site [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review

Barreto

Medeiros

Shearer

et al. 2022

JFB

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Nano-/micron-sized bioactive glass (BG) particles are attractive candidates for both soft and hard tissue engineering. They can chemically bond to the host tissues, enhance new tissue formation, activate cell proliferation, stimulate the genetic expression of proteins, and trigger unique anti-bacterial, anti-inflammatory, and anti-cancer functionalities. Recently, composites based on biopolymers and BG particles have been developed with various state-of-the-art techniques for tissue engineering. Gelatin, a semi-synthetic biopolymer, has attracted the attention of researchers because it is derived from the most abundant protein in the body, viz., collagen. It is a polymer that can be dissolved in water and processed to acquire different configurations, such as hydrogels, fibers, films, and scaffolds. Searching “bioactive glass gelatin” in the tile on Scopus renders 80 highly relevant articles published in the last ~10 years, which signifies the importance of such composites. First, this review addresses the basic concepts of soft and hard tissue engineering, including the healing mechanisms and limitations ahead. Then, current knowledge on gelatin/BG composites including composition, processing and properties is summarized and discussed both for soft and hard tissue applications. This review explores physical, chemical and mechanical features and ion-release effects of such composites concerning osteogenic and angiogenic responses in vivo and in vitro. Additionally, recent developments of BG/gelatin composites using 3D/4D printing for tissue engineering are presented. Finally, the perspectives and current challenges in developing desirable composites for the regeneration of different tissues are outlined.

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Section: Bone Engineeringmentioning

confidence: 99%

Section: Bioactive Glasses (Bgs)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review

Barreto

Medeiros

Shearer

et al. 2022

JFB

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Section: Bone Engineeringmentioning

confidence: 99%

“…The action of different ions that stimulate cellular metabolism allows the application of these materials in the repair of bone defects, tissue regeneration, wound healing, cell support, drug delivery, etc. [1,93,127,128] Studies published in recent years have proven that these materials can act with similar efficacy to classic orthopedic applications in the treatment of difficult-to-heal wounds and in the control of hemorrhages through the release of SiO4 -4 species. These units stimulate the signaling of growth factors and proteins in addition to promoting the activation of clotting factors, processes that are essential for accelerating the proliferation of epithelial cells and reducing inflammation.…”

Section: Bioactive Glasses (Bgs)mentioning

confidence: 99%

Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review

Barreto¹,

Medeiros²,

Shearer³

et al. 2022

Preprint

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Nano/micron-sized bioactive glass (BG) particles are attractive candidates for both soft and hard tissue engineering. They can chemically bond to the host tissues, enhance new tissue formation, activate cell proliferation, stimulate the genetic expression of proteins, and trigger unique an-ti-bacterial, anti-inflammatory, and anti-cancer functionalities. Recently, composites based on bi-opolymers and BG particles have been developed with various state-of-the-art techniques for tis-sue engineering. Gelatin, a semi-synthetic biopolymer, has attracted the attention of researchers because it is derived from the most abundant protein in the body, viz., collagen. It is a polymer that can be dissolved in water and processed to acquire different configurations, such as hydro-gels, fibers, films, scaffolds, etc. Searching "bioactive glass gelatin" in the tile on Scopus renders 80 highly relevant articles published in the last ~10 years, which signifies the importance of such composites. First, this review addresses the basic concepts of soft and hard tissue engineering, in-cluding the healing mechanisms and limitations ahead. Then, current knowledge on gelatin/BG composites including composition, processing and properties is summarized and discussed both for soft and hard tissue applications. This review explores physical, chemical and mechanical features and ion-release effects of such composites concerning osteogenic and angiogenic respons-es in vivo and in vitro. Additionally, recent developments of BG/gelatin composites using 3D/4D printing for tissue engineering are presented. Finally, the perspectives and current challenges in developing desirable composites for the regeneration of different tissues are outlined.

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