Bioactıve Glass‐Polymer Nanocomposites for Bone Tıssue Regeneration Applicatıons: A Revıew

Taygun, Melek Erol; Ünalan, Irem; Idris, Maizlinda Izwana; Mano, João F.; Boccaccını, Aldo R.

doi:10.1002/adem.201900287

Cited by 37 publications

(22 citation statements)

References 228 publications

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“…This is especially true for polymers, since they are very versatile in composite materials preparation. Polymers composited with HA, BGs, and SiO 2 ceramics for BTE applications have been reported. These systems improved the performance of the scaffolds by reducing the adverse effects of each individual components; however, it is a highly case‐by‐case situation, and a general solution is hard to achieve.…”

Section: Traditional Scaffolds For Bone Tissue Engineeringmentioning

confidence: 99%

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Peng

Zhao

Zhou

et al. 2020

Adv Healthcare Materials

116

106

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Bone tissue engineering (BTE) has received significant attention due to its enormous potential in treating critical‐sized bone defects and related diseases. Traditional materials such as metals, ceramics, and polymers have been widely applied as BTE scaffolds; however, their clinical applications have been rather limited due to various considerations. Recently, carbon‐based nanomaterials attract significant interests for their applications as BTE scaffolds due to their superior properties, including excellent mechanical strength, large surface area, tunable surface functionalities, high biocompatibility as well as abundant and inexpensive nature. In this article, recent studies and advancements on the use of carbon‐based nanomaterials with different dimensions such as graphene and its derivatives, carbon nanotubes, and carbon dots, for BTE are reviewed. Current challenges of carbon‐based nanomaterials for BTE and future trends in BTE scaffolds development are also highlighted and discussed.

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Section: Traditional Scaffolds For Bone Tissue Engineeringmentioning

confidence: 99%

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Peng

Zhao

Zhou

et al. 2020

Adv Healthcare Materials

116

106

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“…[41] Overall, these results prove that the simultaneous release of calcium and phosphate ions by the MSN-CaP nanoparticles induce mineralization, making these materials osteoconductive, with good potential for bone tissue regeneration. [42][43][44] The MSN-CaP materials show stronger bioactivity than similar nonporous nanoparticles, probably due to the larger specific surface area of MSNs. [45] In fact, our previous bioactivity studies with nonporous silica nanoparticles containing calcium and phosphate ions showed a slower response.…”

Section: In Vitro Bioactivitymentioning

confidence: 99%

Efficient Single‐Dose Induction of Osteogenic Differentiation of Stem Cells Using Multi‐Bioactive Hybrid Nanocarriers

et al. 2020

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such as limited bone supply, donor site morbidity, risk of infection, or loss of function. [2,3] Synthetic permanent bone substitution grafts are alternative options, however, those show poor osteointegration, may release toxic ions, and present differences in the mechanical properties at the bone/prosthesis interface that can give rise to ruptures. [1,4] Bone tissue engineering offers an alternative approach, with the potential to repair critical size defects and promote bone regeneration. Although different nanomaterials with osteocompatible, osteoconductive, or osteoinductive effects have been previously described in the literature, [5-8] here we propose an original multifunctional approach based on a hybrid silica nanomaterial that can release calcium and phosphate ions intracellularly, and simultaneously deliver a pro-osteogenic substance, dexamethasone (Dex). We hypothesize that the simultaneous intracellular delivery of different stimuli will result in synergistic effects that allow a scaffold-free strategy to induce the differentiation of stem cells into osteoblasts. Silica nanomaterials (and their degradation products) are biocompatible and "generally recognized as safe" (GRAS) by the U.S. Food and Drug Administration (FDA). [9] The degradation rate of silica nanoparticles depends on their size, porosity, and other parameters, [10] and it has been shown that mesoporous silica nanoparticles (MSNs) with 180 nm diameter degraded over 50% in 3 d, and nearly 100% in 7 d. [11] Large size silicabased bioactive materials have been used in orthopedic applications, [12,13] because they are biocompatible, [14] biodegradable, [15] osteoconductive, [16] and even angiogenic. [13,15] Silica released from these materials, together with calcium and phosphate ions, originate both intracellular and extracellular responses that activate the cells in contact with this stimulus. [15,17,18] Previous studies showed how calcium ions stimulate osteoblast proliferation and differentiation, while phosphate ions enhance the rate of bone matrix production by osteogenic cells. [19,20] This spatiotemporally controlled release also induces the formation of a hydroxyapatite layer, which allows bonding to the bone tissue, hence improving osteointegration. [15,21] This process can be greatly improved by using nanosized bioactive materials, which due to their large specific surface area Bone regeneration requires the presence of specific factors to induce the differentiation of stem cells into osteoblasts. These factors induce osteogenesis by stimulating the expression of bone-related proteins, bone cell proliferation and differentiation. Herein, bioactive mesoporous silica nanoparticles are doped with calcium and phosphate ions while the porous network is loaded with dexamethasone (MSN-CaPDex). The bioactive MSN-CaPDex nanocarriers are prepared without affecting the narrow size distribution, pore structure, and morphology of the MSNs, while incorporating multi-stimuli, complementary ionic/biochemical bioactive mediators. The bioactive nano...

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“…Using universal adhesives in SE mode limit the demineralization of dentin to leave some minerals for chemical bonding. 34 However, the hydrophilic nature of dentin as well as the hydrophilicity of the adhesive may lead to increase the water content in the adhesive layer which might impair polymerization and decrease bond strength to dentin. 27 On the other hand, ER mode, remove smear layer, demineralize few microns of dentin layer and allow for resin impregnation and form micromechanical interlocking.…”

Section: Discussionmentioning

confidence: 99%

Shear Bond Strength of a Multi-Mode Universal Adhesive Containing Hydroxy-Apatite Nanoparticles to Dentin (In vitro study)

Ghyadh

Ragab

Osman

2021

Egyptian Dental Journal

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Aim: To evaluate the effect of addition of Hydroxyl-Apatite nanoparticles to a commercial universal adhesive on sheer-bond-strength to dentin using two application modes, immediately and after thermocycling. Methods: A-commercial UA was used for bonding composite-resin to dentin and considered as control. 10% of HAp were prepared and added to the commercial UA and considered as experimental. 88-freshly extracted sound human premolar teeth were sectioned to expose midcoronal-dentin. Samples were y divided into: control and experimental group. Each group was further divided based on the application protocol. Half of the samples were stored in distilled water for 24h at 37°C for immediate SBS testing whereas the other half was subjected to thermocycling for 20,000 cycles. SBS was measured one-day post polymerization and after thermocycling using universal testing machine. SBS values and failure modes were recorded and statistically analyzed.Results: the experimental group presented significantly lower resin-dentin SBS than the control group. Thermocycling significantly lowered SBS values for both groups. When using SE mode, the experimental group reported lower resin-dentin SBS than the control group before and after thermocyclying. When using ER mode before thermocycling, no significant difference was found between the two groups, while after thermocycling, the experimental group reported significantly higher resin-dentin SBS than the control group. For both adhesive groups, mixed failure dominated with ER mode while adhesive failure dominated with SE mode.Conclusions: Addition of HA may provide resistance to degradation and offer a potential to improve resin-dentin bond stability against thermal changes when ER protocol is applied.

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Bioactıve Glass‐Polymer Nanocomposites for Bone Tıssue Regeneration Applicatıons: A Revıew

Cited by 37 publications

References 228 publications

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Efficient Single‐Dose Induction of Osteogenic Differentiation of Stem Cells Using Multi‐Bioactive Hybrid Nanocarriers

Shear Bond Strength of a Multi-Mode Universal Adhesive Containing Hydroxy-Apatite Nanoparticles to Dentin (In vitro study)

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