Bioactive glass–ionomer cement with potential therapeutic function to dentin capping mineralization

Abstract

We have developed a novel bioactive resin-modified glass-ionomer cement system with therapeutic function to dentin capping mineralization. In the system, the newly synthesized star-shape poly(acrylic acid) was formulated with water, Fuji II LC filler, and bioactive glass S53P4 to form resin-modified glass-ionomer cement. Compressive strength (CS) was used as a screening tool for evaluation. The commercial glass-ionomer cement Fuji II LC was used as a control. All the specimens were conditioned in simulated body fluid (SBF) at 37 degrees C prior to testing. The effect of aging in SBF on CS and microhardness of the cements was investigated. Scanning electron microscopy was used to examine the in vitro dentin surface changes caused by the incorporation of bioactive glass. The results show that the system not only provided strengths comparable to original commercial Fuji II LC cement but also allowed the cement to help mineralize the dentin in the presence of SBF. It appears that this bioactive glass-ionomer cement system has direct therapeutic impact on dental restorations that require root surface fillings.

A novel bioactive agent improves adhesion of resin-modified glass-ionomer to dentin

“…Resin/glass ionomer ratio in RMGICs also determines physical and mechanical properties 14 . Vitremer attained improved integration of matrix and particles than Fuji II LC, consequently, with less voids or defects 22 . When 2 %wt Biosilicate was incorporated powder was diminished just in 0.5 for FL and in 0.3 for VT, and no differences in compressive strength were encountered.…”

Effect of Resin-Modified Glass Ionomer Containing Bioactive Glass on the Flexural Strength and Morphology of Demineralized Dentin

“…31 In the present study, RMGI-BAG increased the FS values of undemineralized dentin and demineralized dentin around 10% and 20%, respectively, revealing statistically significant differences in the latter case. Xie and others 25 reported remineralization of dentin disks immersed in SBF along with BAG; however, they did not measure the strength of the dentin. Efflandt and others 18 evaluated the effect of BAG on dentin and chemically analyzed the dentin-material interface, reporting the presence of apatite.…”

“…41 Different SBF solutions are buffered solutions with a physiologic pH value of 7.4 and an ionic composition similar to that of plasma; they are predominantly produced by dissolving sodium chloride, sodium bicarbonate, potassium chloride, dipotassium phosphate, magnesium chloride, calcium chloride, and sodium sulfate in distilled water. 20,[25][26][27] The ionic concentration of the prepared SBF for this study in terms of millimolars is presented in Table 2. As previously mentioned, in the majority of such studies, this solution has been used and good results have been reported.…”

“…24,25,27,30 The mixtures were placed in stainless steel molds until the molds were slightly overfilled. The unset material was gently compressed with a transparent plastic matrix and a glass slab.…”

“…[23][24][25][26][27][28][29][30] Some of these materials are already under patent. 23 These experimental GIC-BAG materials have been reported to exhibit bioactivity in simulated physiologic conditions, and they have been shown to remineralize human dentin [24][25][26][27] Some of the mechanical properties of this combination have been evaluated in recent studies. 23,28,29 Ana and others 30 reported that the compressive strength of RMGI containing BAG decreases but is still much higher than that of conventional GIC containing BAG.…”