Bioactive glass in the treatment of ulcerative colitis to regulate the TLR4 / MyD88 / NF-κB pathway

Wang, Wenhao; Jia, Shengyuan; Miao, Guohou; Sun, Zijie; Feng, Yu; Gao, Zhixing; Li, Yuli

doi:10.1016/j.bioadv.2023.213520

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…Bioactive glass repaired induced ulcerative colitis wounds in rats through significant upregulation of some inflammatory pathways[ 34 ]. Despite the wide range of applications of bioceramics in soft tissue regeneration, the introduction of bioceramics in lung and cardiac tissue regeneration research is still uncommon[ 24 ].…”

Section: Bioceramics In Soft Tissue Regenerationmentioning

confidence: 99%

Advances in clinical applications of bioceramics in the new regenerative medicine era

Elshazly,

Nasr,

Hamdy

et al. 2024

World J Clin Cases

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In this editorial, we comment on the hard and soft tissue applications of different ceramic-based scaffolds prepared by different mechanisms such as 3D printing, sol-gel, and electrospinning. The new concept of regenerative medicine relies on biomaterials that can trigger in situ tissue regeneration and stem cell recruitment at the defect site. A large percentage of these biomaterials is ceramic-based as they provide the essential requirements of biomaterial principles such as tailored multisize porosity, antibacterial properties, and angiogenic properties. All these previously mentioned properties put bioceramics on top of the hierarchy of biomaterials utilized to stimulate tissue regeneration in soft and hard tissue wounds. Multiple clinical applications registered the use of these materials in triggering soft tissue regeneration in healthy and diabetic patients such as bioactive glass nanofibers. The results were promising and opened new frontiers for utilizing these materials on a larger scale. The same results were mentioned when using different forms and formulas of bioceramics in hard defect regeneration. Some bioceramics were used in combination with other polymers and biological scaffolds to improve their regenerative and mechanical properties. All this progress will enable a larger scale of patients to receive such services with ease and decrease the financial burden on the government.

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Section: Bioceramics In Soft Tissue Regenerationmentioning

confidence: 99%

Advances in clinical applications of bioceramics in the new regenerative medicine era

Elshazly,

Nasr,

Hamdy

et al. 2024

World J Clin Cases

View full text Add to dashboard Cite

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Bioactive Glass in Tissue Regeneration: Unveiling Recent Advances in Regenerative Strategies and Applications

Zhu,

Zhang,

Chang

et al. 2024

Advanced Materials

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Bioactive glass (BG) is a class of biocompatible, biodegradable, multifunctional inorganic glass materials, which is successfully used for orthopedic and dental applications, with several products already approved for clinical use. Apart from exhibiting osteogenic properties, BG is also known to be angiogenic and antibacterial. Recently, BG's role in immunomodulation has been gradually revealed. While the therapeutic effect of BG is mostly reported in the context of bone and skin‐related regeneration, its application in regenerating other tissues/organs, such as muscle, cartilage, and gastrointestinal tissue, has also been explored recently. The strategies of applying BG have also expanded from powder or cement form to more advanced strategies such as fabrication of composite polymer‐BG scaffold, 3D printing of BG‐loaded scaffold, and BG‐induced extracellular vesicle production. This review presents a concise overview of the recent applications of BG in regenerative medicine. Various regenerative strategies of BG will be first introduced. Next, the applications of BG in regenerating various tissues/organs, such as bone, cartilage, muscle, tendon, skin, and gastrointestinal tissue, will be discussed. Finally, summarizing clinical applications of BG for tissue regeneration will conclude, and outline future challenges and directions for the clinical translation of BG.

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Bioactive glass in the treatment of ulcerative colitis to regulate the TLR4 / MyD88 / NF-κB pathway

Cited by 2 publications

References 54 publications

Advances in clinical applications of bioceramics in the new regenerative medicine era

Advances in clinical applications of bioceramics in the new regenerative medicine era

Bioactive Glass in Tissue Regeneration: Unveiling Recent Advances in Regenerative Strategies and Applications

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