Bioactive glass granules as a bone adjunctive material in maxillary sinus floor augmentation

Turunen, Tia; Peltola, J.; Yli‐Urpo, Antti; Happonen, Risto‐Pekka

doi:10.1111/j.1600-0501.2004.00989.x

Cited by 83 publications

(80 citation statements)

References 29 publications

(42 reference statements)

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“…TURUNEN et al 35 presented comparable results for both groups after 4 months of healing. In the control group 25% of new bone was seen and in the test group 26%.…”

Section: Histomorphometric Resultsmentioning

confidence: 83%

“…When applied in the size range of 300-355 mm, bioactive glass showed osteoconductive properties 28,29 . TURUNEN et al 35 showed that the combined use of bioactive glass granules with autogenous bone chips for augmentation of the maxillary sinus floor diminished the amount of bone needed for augmentation and resulted in the same quantity of bone as when autogenous bone chips alone were used. TADJOEDIN et al 28 showed in the control group, using bioactive glass particles in combination with autogenous bone, that new bone formation increased rapidly within 2 months, from 29% at 4 months to 38% at 6 months.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Maxillary sinus lift with solely autogenous bone compared to a combination of autogenous bone and growth factors or (solely) bone substitutes. A systematic review

Rickert¹,

Slater²,

Meijer³

et al. 2012

International Journal of Oral and Maxillofacial Surgery

114

113

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“…TURUNEN et al 35 presented comparable results for both groups after 4 months of healing. In the control group 25% of new bone was seen and in the test group 26%.…”

Section: Histomorphometric Resultsmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Maxillary sinus lift with solely autogenous bone compared to a combination of autogenous bone and growth factors or (solely) bone substitutes. A systematic review

Rickert¹,

Slater²,

Meijer³

et al. 2012

International Journal of Oral and Maxillofacial Surgery

114

113

View full text Add to dashboard Cite

show abstract

“…Although bioactive glasses have been used for over 15 years with success in oral and maxillo-facial clinical applications (Froum et al, 1998;Peltola et al, 2006), limited benefits have been reported (Turunen et al, 2004;Wang et al, 2005). Recently, due to the growing evidence showing that strontium influences bone cells and bone metabolism in vitro and in vivo (Marie, 2006), melt-derived strontiumdoped bioactive glasses prepared from a base 45S5 bioglass have been developed and implanted in rat tibia bone marrow (Gorustovich et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Effects of strontium-doped bioactive glass on the differentiation of cultured osteogenic cells

Isaac

Nohra²,

Lao³

et al. 2011

eCM

159

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There is accumulating evidence that strontium-containing biomaterials have positive effects on bone tissue repair. We investigated the in vitro effect of a new Sr-doped bioactive glass manufactured by the sol-gel method on osteoblast viability and differentiation. Osteoblasts isolated from foetal mouse calvaria were cultured in the presence of bioactive glass particles; particles were undoped (B75) or Sr-doped with 1 wt.% (B75-Sr1) and 5 wt.% (B75-Sr5). Morphological analysis was carried out by contrast-phase microscopy and scanning electron microscopy (SEM). Cell viability was evaluated by the MTS assay at 24 h, 48 h and 72 h. At 24 h, day 6 and day 12, osteoblast differentiation was evaluated by assaying alkaline phosphatase (ALP) activity, osteocalcin (OC) secretion and gene expression of various bone markers, using Real-Time-PCR. Alizarin Red staining and ALP histoenzymatic localisation were performed on day 12. Microscopic observations and MTS showed an absence of cytotoxicity in the three investigated bioactive glasses. B75-Sr5 particles in cell cultures, in comparison with those of B75 and B75-Sr1, resulted in a significant up-regulation of Runx2, Osterix, Dlx5, collagen I, ALP, bone sialoprotein (BSP) and OC mRNA levels on day 12, which was associated with an increase of ALP activity on day 6 and OC secretion on day 12. In conclusion, osteoblast differentiation of foetal mouse calvarial cells was enhanced in the presence of bioactive glass particles containing 5 wt.% strontium. Thus, B75-Sr5 may represent a promising bone-grafting material for bone regeneration procedures.

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“…Since then, bioactive glasses have been used in a variety of different shapes such as plates, bulks, granules and powder in many medical and dental applications. In head and neck surgery, bioactive glass has been applied in reconstruction of orbital floor fractures and defects of facial bones, in filling of frontal sinuses, in augmentation of the maxillary sinus floor, in grafting periodontonal bone defects and in middle ear surgery (29)(30)(31)(32)(33)(34)(35). In orthopaedic applications, bioactive glass has been tested as a filler of benign tumors in 12 patients (36).…”

Section: Clinical Applications Of Bioactive Glassmentioning

confidence: 99%

Molecular Basis for Action of Bioactive Glasses as Bone Graft Substitute

2006

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Bone grafting procedures are undergoing a major shift from autologous and allogeneic bone grafts to synthetic bone graft substitutes. Bioactive glasses are a group of synthetic silica-based bioactive materials with bone bonding properties first discovered by Larry Hench. They have several unique properties compared with other synthetic bioresorbable bioactive ceramics, such as calcium phosphates, hydroxyapatite (HA) and tricalcium phosphate (TCP). Bioactive glasses have different rates of bioactivity and resorption rates depending on their chemical compositions. The critical feature for the rate of bioactivity is a SiO 2 content <60% in weight. In vivo, the material is highly osteoconductive and it seems to promote the growth of new bone on its surface. In a recent study, the activity of the material was found even to overshadow the effect of BMP-2 gene therapy. In vivo, there is a dynamic balance between intramedullary bone formation and bioactive glass resorption. Recent studies of molecular biology have shown that bioactive glass induces a high local turnover of bone formation and resorption. Many osteoporotic fracture patients are candidates for concurrent treatment with bisphosphonates and bioceramic bone graft substitutes. Since osteopromotive silicabased bioactive glasses induce accelerated local bone turnover, adjunct antiresorptive agents may affect the process. However, a recent study showed that an adjunct antiresorptive therapy (zoledronic acid) is even beneficial for bone incorporation of bioactive glass. Based on these observations, bioactive glasses are a promising group of unique biomaterials to act as bone graft substitutes.

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Bioactive glass granules as a bone adjunctive material in maxillary sinus floor augmentation

Abstract: The results indicate that BG granules (S53P4) can be used together with AB chips for sinus floor augmentation procedure, thus decreasing the amount of bone needed. Further studies concerning especially the biomechanical properties of the BG-AB complex with dental implants are needed.

Cited by 83 publications

References 29 publications

Maxillary sinus lift with solely autogenous bone compared to a combination of autogenous bone and growth factors or (solely) bone substitutes. A systematic review

Maxillary sinus lift with solely autogenous bone compared to a combination of autogenous bone and growth factors or (solely) bone substitutes. A systematic review

Effects of strontium-doped bioactive glass on the differentiation of cultured osteogenic cells

Molecular Basis for Action of Bioactive Glasses as Bone Graft Substitute

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