Bioactive Glass Coating for Hard and Soft Tissue Bonding on Ti6Al4V and Silicone Rubber Using Electron Beam Ablation

Schrooten, Jan; Jaecques, Siegfried; Eloy, R.; Delubac, Claire; Schultheiss, Christoph; Brenner, Philipp; Buth, L.; Humbeeck, Jan Van; Sloten, J. Vander

doi:10.4028/www.scientific.net/kem.254-256.427

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…This latter work was previously supported by the findings of Lin et al, 95 who reported the ability of BG to support rapid wound closure in a rabbit model. In the same direction, these results are in agreement with those reported by Schrooten et al, 96 who used electron beam ablation to coat silicone rubber with bioactive glass for percutaneous implants.…”

Section: Biological Evaluations For Specific Applicationssupporting

confidence: 92%

Biological evaluation of preceramic organosilicon polymers for various healthcare and biomedical engineering applications: A review

Francis

2020

J Biomed Mater Res

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Preceramic organosilicon materials combining the properties of a polymer and an inorganic ceramic phase are of great interest to scientists working in biomedical sciences. The interdisciplinary nature of organosilicon polymers and their molecular structures, as well as their diversity of applications have resulted in an unprecedented range of devices and synergies cutting across unrelated fields in medicine and engineering. Organosilicon materials, especially the polysiloxanes, have a long history of industrial and medical uses in many versatile aspects as they can be easily fabricated into complex‐shaped products using a wide variety of computer‐aided or polymer manufacturing techniques. Thus far, intensive research activities have been mainly devoted to the processing of preceramic organosilicon polymers toward magnetic, electronic, structural, optical, and not biological applications. Herein we present innovative research studies and recent developments of preceramic organosilicon polymers at the interface with biological systems, displaying the versatility and multi‐functionality of these materials. This article reviews recent research on preceramic organosilicon polymers and corresponding composites for bone tissue regeneration and medical engineering implants, focusing on three particular topics: (a) surface modifications to create tailorable and bioactive surfaces with high corrosion resistance and improved biological properties; (b) biological evaluations for specific applications, such as in glaucoma drainage devices, orthopedic implants, bone tissue regeneration, wound dressing, drug delivery systems, and antibacterial activity; and (c) in vitro and in vivo studies for cytotoxicity, genotoxicity, and cell viability. The interest in organosilicon materials stems from the fact that a vast array of these materials have complementary attributes that, when integrated appropriately with functional fillers and carefully controlled conditions, could be exploited either as polymeric Si‐based composites or as organosilicon polymer‐derived Si‐based ceramic composites to tailor and optimize properties of the Si‐based materials for various proposed applications.

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Section: Biological Evaluations For Specific Applicationssupporting

confidence: 92%

Biological evaluation of preceramic organosilicon polymers for various healthcare and biomedical engineering applications: A review

Francis

2020

J Biomed Mater Res

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“…This has been reported earlier by Fahrni et al (2009) in a mixture of iron oxide nanoparticles in poly(dimethylsiloxane) [36]. Schrooten et al (2004) already reported the use of a BG coating with silicone rubber for percutaneous implants [37]. They used electron beam ablation to coat poly(dimethylsiloxane) with bioactive glass.…”

Section: Manufacturingmentioning

confidence: 55%

Bioactive glass containing silicone composites for left ventricular assist device drivelines: role of Bioglass 45S5® particle size on mechanical properties and cytocompatibility

et al. 2017

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Aside its historical use in contact with bone and teeth, an increasing number of studies use bioactive glasses (BG) in contact with soft tissue. BG could provide solutions for various medical problems. This study presents a first evaluation, whether BG containing silicone elastomers are a suitable material for left ventricular assist device drivelines and could enhance skin biointegration thereof. Three different nano-or microparticles of BG45S5® were incorporated into medical grade silicone elastomer and thin films of the composites were manufactured. Physicochemical, mechanical and in vitro experiments using primary human dermal fibroblasts were used to evaluate the nano-and microcomposites. The incorporation of BG particles reduced the tensile strength at break and percent elongation at break of the composites and increased the stiffness of the material. Especially the incorporation of nanosized BG decreased the percent elongation at break after immersion in SBF due to agglomerate formation and increased hydroxyapatite formation compared to commercially available microparticles. The cytocompatibility of BG containing composites increased significantly with increasing particle concentration. A clear trend regarding particle size was not observed. In general, the simple incorporation of particles into medical grade silicone elastomer allowed an easy modification of the mechanical properties and improvement in bioactivity (assessed by hydroxyapatite formation) of the material. The choice of either nano-or microparticles depends on the specific application and requirements for the material, as different particle types show different advantages and disadvantages.

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Controlling Adhesiveness of Material-tissue Interface for the Prevention of Catheter Infection

Taguchi¹

2011

Journal of the Adhesion Society of Japan

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Bioactive Glass Coating for Hard and Soft Tissue Bonding on Ti6Al4V and Silicone Rubber Using Electron Beam Ablation

Cited by 4 publications

References 8 publications

Biological evaluation of preceramic organosilicon polymers for various healthcare and biomedical engineering applications: A review

Biological evaluation of preceramic organosilicon polymers for various healthcare and biomedical engineering applications: A review

Bioactive glass containing silicone composites for left ventricular assist device drivelines: role of Bioglass 45S5® particle size on mechanical properties and cytocompatibility

Controlling Adhesiveness of Material-tissue Interface for the Prevention of Catheter Infection

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