Bioactive flavonoids and stilbenes from the leaf of Morus alba var. multicaulis

Hao, Mimi; Huang, Peijian; Ruan, Jing; Sun, Fan; Han, Lifeng; Li, Mengyang; Zhang, Yi; Wang, Tao

doi:10.1016/j.fitote.2021.105018

Cited by 11 publications

(7 citation statements)

References 26 publications

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“…Many anticancer flavonoids (among others, luteolin and quercetin) are inhibitors of the enzyme FAS [ 37 ]. Moreover, flavonoids like the tetrahydroxyflavone kuwanone G [ 38 ] showed potential inhibition of SCD, the enzyme that inserts a double bond in the Δ 9 position of 16:0 and 18:0 to generate 16:1 n-7 and 18:1 n-9 [ 29 , 39 , 40 ]. The predominant polar lipid class in HeLa cell membranes are phosphatidylcholines (PC) (53%), and PC 16:0/18:1 and PC18:1/18:1 are the dominant ones [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Xanthomicrol Activity in Cancer HeLa Cells: Comparison with Other Natural Methoxylated Flavones

et al. 2023

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The methoxylated flavone xanthomicrol represents an uncommon active phenolic compound identified in herbs/plants with a long application in traditional medicine. It was isolated from a sample of Achillea erba-rotta subsp. moschata (musk yar-row) flowering tops. Xanthomicrol promising biological properties include antioxidant, anti-inflammatory, antimicrobial, and anticancer activities. This study mainly focused on the evaluation of the xanthomicrol impact on lipid metabolism in cancer HeLa cells, together with the investigation of the treatment-induced changes in cell growth, morphology, and apoptosis. At the dose range of 5–100 μM, xanthomicrol (24 h of incubation) significantly reduced viability and modulated lipid profile in cancer Hela cells. It induced marked changes in the phospholipid/cholesterol ratio, significant decreases in the levels of oleic and palmitic acids, and a marked increase of stearic acid, involving an inhibitory effect on de novo lipogenesis and desaturation in cancer cells. Moreover, marked cell morphological alterations, signs of apoptosis, and cell cycle arrest at the G2/M phase were observed in cancer treated cells. The bioactivity profile of xanthomicrol was compared to that of the anticancer methoxylated flavones eupatilin and artemetin, and structure–activity relationships were underlined.

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Section: Discussionmentioning

confidence: 99%

Xanthomicrol Activity in Cancer HeLa Cells: Comparison with Other Natural Methoxylated Flavones

et al. 2023

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“…The structures of the known compounds sanggenon W ( 2 ), morusinol ( 4 ), morusin ( 5 ), kuwanon C( 6 ), 5,7,2′,4′,-tetrahydroxy-3-geranylflavone ( 7 ), 3′-geranyl-3-prenyl-2′,4′,5,7-tetrahydroxyflavone ( 8 ), 5′-geranyl-5,7,2′,4′,-tetrahydroxyl-flavone ( 9 ), and sanggenone K ( 10 ) were elucidated by comparison of their spectroscopic data with those of the reported literature. Meanwhile, compounds 7 and 9 were purified from mulberry leaves for the first time.…”

Section: Resultsmentioning

confidence: 99%

Inhibitory Mechanism of Prenylated Flavonoids Isolated from Mulberry Leaves on α-Glucosidase by Multi-Spectroscopy and Molecular Dynamics Simulation

Tian

Zhao

et al. 2023

J. Agric. Food Chem.

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Flavonoids have always been considered as the chemical basis for the hypoglycemic effect of mulberry leaves. In the course of our search for hypoglycemic effect agents from natural sources, a systematic study was launched to explore prenylated flavonoids from mulberry leaves. Herein, chemical investigation led to the isolation of 10 characteristic prenylated flavonoids, including two new compounds (1 and 3). Their structures were elucidated based on spectroscopic data. All compounds exhibited good α-glucosidase inhibitory activity in vitro, among which compound 2 had the best activity (IC 50 = 2.6 μM), better than acarbose (IC 50 = 19.6 μM). Additional in vivo tests have further demonstrated compound that compound 2 has a good ability to reduce postprandial blood glucose. Then, multi-spectroscopic methods and molecular simulation studies were used to study the inhibition mechanism. The results showed that compound 2 was a mixed inhibition of α-glucosidase and the binding process was spontaneous, with van der Waals forces as the main driving force, followed by hydrogen bonding and electrostatic forces. The above studies enriched the chemical basis of mulberry leaves, and the application of computational chemistry also provided a reference for future research on such structures.

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“…The HPLC chromatogram of MLE generated by full-scan diode array detector (PDA) and the structures of identified components were shown in Figure 1A,B, respectively. These compounds have been identified in mulberry leaves and the flavonoids were major components in MLE [25,26]. components with higher peak areas in HPLC (3-5) were compared with commercial standards, and the identities of the compounds were confirmed.…”

Section: The Main Components In Mlementioning

confidence: 94%

Mulberry Leaf Extract Improves Metabolic Syndrome by Alleviating Lipid Accumulation In Vitro and In Vivo

Xing

Ren

et al. 2022

Molecules

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Metabolic syndrome (MS) is a metabolic disease with multiple complications. Mulberry leaf extract (MLE) is rich in flavonoids and has great potential in alleviating glucose and lipid metabolism disorders. This study evaluated the effect and mechanism of MLE on the alleviation of MS. The components of the MLE were analyzed, and then the regulation of lipid metabolism by MLE in vitro and in vivo was determined. In a hepatocyte model of oleic acid-induced lipid accumulation, it was found that MLE alleviated lipid accumulation and decreased the expression of genes involved in lipogenesis. Furthermore, MLE improved obesity, insulin resistance, plasma lipid profile, and liver function in MS mice after a 15-week intervention. MLE decreased the expression of SREBP1, ACC, and FAS through the AMPK signaling pathway to inhibit lipid synthesis and increase the level of CPT1A to promote lipid decomposition to achieve its hypolipidemic effect. Meanwhile, MLE was also shown to affect the composition of the gut microbiota and the production of short-chain fatty acids, which contributed to the alleviation of lipid accumulation. Our results suggest that MLE can improve MS by improving lipid metabolism through multiple mechanisms and can be developed into dietary supplements for the improvement of MS.

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Bioactive flavonoids and stilbenes from the leaf of Morus alba var. multicaulis

Cited by 11 publications

References 26 publications

Xanthomicrol Activity in Cancer HeLa Cells: Comparison with Other Natural Methoxylated Flavones

Xanthomicrol Activity in Cancer HeLa Cells: Comparison with Other Natural Methoxylated Flavones

Inhibitory Mechanism of Prenylated Flavonoids Isolated from Mulberry Leaves on α-Glucosidase by Multi-Spectroscopy and Molecular Dynamics Simulation

Mulberry Leaf Extract Improves Metabolic Syndrome by Alleviating Lipid Accumulation In Vitro and In Vivo

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