2010
DOI: 10.1007/s11095-010-0320-6
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Bioactive Electrospun Scaffolds Delivering Growth Factors and Genes for Tissue Engineering Applications

Abstract: A biomaterial scaffold is one of the key factors for successful tissue engineering. In recent years, an increasing tendency has been observed toward the combination of scaffolds and biomolecules, e.g. growth factors and therapeutic genes, to achieve bioactive scaffolds, which not only provide physical support but also express biological signals to modulate tissue regeneration. Huge efforts have been made on the exploration of strategies to prepare bioactive scaffolds. Within the past five years, electrospun sc… Show more

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Cited by 372 publications
(278 citation statements)
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References 90 publications
(148 reference statements)
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“…[30] Many different types of bioactive molecules have been incorporated into scaffolds of electrospun nanofibers, including growth factors. [31] Growth factors are endogenous proteins capable of binding to cell receptors and directing cellular activities.…”
Section: Incorporation Of Bioactive Moleculesmentioning
confidence: 99%
“…[30] Many different types of bioactive molecules have been incorporated into scaffolds of electrospun nanofibers, including growth factors. [31] Growth factors are endogenous proteins capable of binding to cell receptors and directing cellular activities.…”
Section: Incorporation Of Bioactive Moleculesmentioning
confidence: 99%
“…In this sense, polymer fibers have attracted great interest, including for use as DDS, due to their typical properties, e.g., large surface area-to-volume ratio and possible surface modifications [6][7][8]. Moreover, drugs loaded in polymeric fibers can provide systemic and locoregional therapies compared with other DDS, such as nanoparticles, nanocapsules or micellar systems, which have intrinsic fluidity and are difficult to keep localized in a specific area of the body [9,10].…”
Section: Introductionmentioning
confidence: 99%
“…Despite the fact that tissue engineering has been constantly evolving ever since the first mention of the term in 1987, the clinical use of tissue substitutes is nowadays still far below expectations (13). The primary idea of regenerative medicine was to prepare a carrier from biomaterials in the form of the affected tissue or organ, seed it with the patient's autologous cells and then implant the entire system in the body (14). However, another strategy is currently in precedence.…”
Section: Nanofibers In Regenerative Medicinementioning
confidence: 99%
“…It is much more than just a physical support for the cells. ECM also represents a substrate for cell adhesion via specific ligands, provides and directs cell migration and regulates their growth and functions through a variety of bioactive factors (14,15).…”
Section: Nanofibers In Regenerative Medicinementioning
confidence: 99%