Bioactive Electroconductive Hydrogels Yield Novel Biotransducers for Glucose

Kotanen, Christian N.; Guiseppi‐Elie, Anthony

doi:10.1002/masy.201100164

Cited by 15 publications

(13 citation statements)

References 30 publications

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“…These results indicate that the 8151 potentiostat system's two channels are within a reasonable 1% error for electrochemical redox reactions that are reversible and facile and can make reproducible results when using both channels simultaneously. A high level of reproducibility for this biosensor system has been observed during interrogation with ferrocene monocarboxylic acid (FcCOOH), a well-known redox mediator, which supports these findings [17].…”

Section: Accuracy Of Response Of the 8151 Potentiostat Channelsmentioning

confidence: 65%

“…This indicates that OO-ECH transducers cannot be accurately characterized using simplified models. The overall increase in impedance for ECH modified transducers can be attributed to both diffusional limitations imparted by the hydrogel [35], [36] as well as the anion screening capability of polypyrrole that has been previously reported [17]. The faradaic component of the FcCOOH reaction with the MDEA transducer is made more facile with the freshly prepared ECH as can be seen in the low frequency domain.…”

Section: Accuracy Of Response Of the 8151 Potentiostat Channelsmentioning

confidence: 85%

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Characterization of a Wireless Potentiostat for Integration With a Novel Implantable Biotransducer

Kotanen

Guiseppi‐Elie

2014

IEEE Sensors J.

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Wireless potentiostats are being developed and commercialized for use in the development of implantable electrochemical biosensors for the monitoring of physiological markers in a wide range of pathologies. The merits and drawbacks of the Pinnacle 8151 dual potentiostat were investigated for use with a novel implantable biotransducer, the dual responsive microdisc electrode array (MDEA 5037) of ABTECH Scientific. The potentiostat was evaluated with R and RC dummy cells and with MDEA transducers modified with polypyrrolepoly(2-hydroxyethyl methacrylate) electroconductive hydrogels that were all qualified by calibrated ac impedance spectroscopy. In a laboratory setting, the 8151 potentiostat maintained a steady and unbroken signal as far away as 75 ft (23 m), and when unobstructed, up to 100 ft (30 m). The error between the two channels was determined to be 6.4 (±0.3)% and 0.7 (±0.1)% for resistor-capacitor dummy cells (RC = nominally 10 M and 1 μF) and resistor dummy cells (R = nominally 10 M ), respectively. The intra-channel variability was judged to be too large for exacting analyte determinations.

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Section: Accuracy Of Response Of the 8151 Potentiostat Channelsmentioning

confidence: 65%

Section: Accuracy Of Response Of the 8151 Potentiostat Channelsmentioning

confidence: 85%

Characterization of a Wireless Potentiostat for Integration With a Novel Implantable Biotransducer

Kotanen

Guiseppi‐Elie

2014

IEEE Sensors J.

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“…Blood from a patient sample and several camel tissue specimens were analyzed using the Ibis T5000 biosensor (www.abbott.com/newsmedia/press-releases/2011Feb07_2.htm-50k-2011- [11][12][13][14][15][16][17][18][19] 41 .…”

Section: Abbott Laboratoriesmentioning

confidence: 99%

Overview of Biosensors Development Around the World

Mongra

Kaur

2012

Int J of Biomed & Adv Res

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Since there are well over 500 companies and research organizations worldwide involved in biosensor development. It is important to note that the major biosensor players were identified in terms of the following criteria: publication output / quality, scientific impact, reputation, and size. The commercialization of biosensor technology has significantly lagged behind the research output. The rationale behind the slow and limited technology transfer could be attributed to cost considerations and some key technical barriers.. Successful biosensors must be versatile to support interchangeable biorecognition elements, and in addition miniaturization must be feasible to allow automation for parallel sensing with ease of operation at a competitive cost. A significant upfront investment in research and development is a prerequisite in the commercialization of biosensors. The progress in such endeavors is incremental with limited success, thus, the market entry for a new venture is very difficult unless a niche product can be developed with a considerable market volume.

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“…Applications for p(HEMA) include wear resistant hydrophilic surface coatings for prosthetics [5], antimicrobial wound dressings [6], intramuscular biosensor http://dx.doi.org/10.1016/j.eurpolymj.2015.07.035 0014-3057/Ó 2015 Elsevier Ltd. All rights reserved. coatings [7], tissue engineering scaffolds [8], generation of bone-like materials [9], imparting hemocompatibility to metal surfaces [10], improving hardness and elasticity of brittle substrates [11], soft contact lenses [12], and sophisticated drug delivery systems [13][14][15]. When conferred with pH and/or biologically derived responsiveness, poly(HEMA)-based hydrogels have been used in responsive drug delivery with engineered feedback control [14,[16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Partitioning of coomassie brilliant blue into DMAEMA containing poly(HEMA)-based hydrogels

Kotanen

Janagam

Idziak

et al. 2015

European Polymer Journal

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a b s t r a c tThe loading and release of anti-inflammatory drugs from hydrogel-coated implantable devices is a demonstrated approach in mitigating the inflammatory response of implantable devices. Poly(2-hydroxyethyl methacrylate)-based hydrogels possessing ionizable 2-(dimethylamino)ethyl methacrylate (DMAEMA) and cross-linked with varying concentrations (1, 3, 5, 7, 9 and 12 mol%) tetra(ethylene glycol) diacrylate (TEGDA) were synthesized and studied for their degree of hydration, glass transition temperature and partitioning of zwitterionic Coomassie Brilliant Blue (CBB), a zwitterionic drug surrogate known to bind to amines. Using UV-Vis spectroscopy, the partition coefficient of CBB within the hydrogels was found to average 6.69 ± 0.12 but to rise monotonically from 6.54 (1 mol%) to 6.84 (12 mol%) as a function of TEGDA mol% or cross-link density in accord with a monotonic reduction of the degree of hydration. The absence of DMAEMA was found to reduce the partition coefficient of CBB from 6.5 to 4.1. Both formulations, with and without DMAEMA (pK a = 7.5), showed an independence of pH over the physiologically relevant range, pH 5-pH 9, confirming that this difference was not due to Henderson-Hasselbalch ionization of the pendant group. The presence of DMAEMA resulted in a 1.44 fold increase in CBB loading confirming complex formation. The absence of DMAEMA still resulted in considerable partitioning of CBB into the hydrogel suggesting that the affinity between CBB and DMAEMA may not be the only relationship controlling the partition coefficient.

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Bioactive Electroconductive Hydrogels Yield Novel Biotransducers for Glucose

Cited by 15 publications

References 30 publications

Characterization of a Wireless Potentiostat for Integration With a Novel Implantable Biotransducer

Characterization of a Wireless Potentiostat for Integration With a Novel Implantable Biotransducer

Overview of Biosensors Development Around the World

Partitioning of coomassie brilliant blue into DMAEMA containing poly(HEMA)-based hydrogels

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