Bioactive effects of strontium loading on micro/nano surface Ti6Al4V components fabricated by selective laser melting

Shimizu, Yu; Fujibayashi, Shunsuke; Yamaguchi, Seiji; Mori, Shigeo; Kitagaki, Hisashi; Shimizu, Takayoshi; Okuzu, Yaichiro; Masamoto, Kazutaka; Goto, Koji; Otsuki, Bungo; Kawai, Toshiyuki; Morizane, Kazuaki; Kawata, Tomotoshi; Matsuda, Shinya

doi:10.1016/j.msec.2019.110519

Cited by 14 publications

(21 citation statements)

References 40 publications

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“…We also compared the value of the stress transfer from implant to peri‐implant bone and bone–implant contact of our PIL with other typical or modified Ti implants. The implants contain alloys and other implant coating materials including plasma treatment of titanium (plasma), [ 51 ] Sr‐incorporated selective laser melting titanium (SLM‐Sr), [ 52 ] Sr‐incorporated micro/nano rough titanium (MNT‐Sr), [ 53 ] sand‐blasting and large‐grit acid etching with hydroxyapatite (HAP) nanocoating (SLA with HA), [ 54 ] epigallocatechin gallate and magnesium ions (EGCG+Mg 2+ ), [ 55 ] micro‐arc oxidation surface‐treated titanium (MST‐Ti), [ 56 ] polyether ether ketone, [ 9 ] TiNb, [ 57 ] poly(lactic acid) hydroxyapatite (PLA‐HA), [ 58 ] and HAP [ 11 ] ( Figure a). Enhancing osteointegration or energy‐dissipation can only be achieved separately in existing implants.…”

Section: Resultsmentioning

confidence: 99%

“…Comparison of the properties of the PIL with other materials. [ 9,11,51–58 ] a) The PIL possesses both stress reduction and increased osteointegration capability compared with the other published materials. Red five‐pointed star: values for the PIL; green circle (horizontal and vertical axis): values for the Ti implant, respectively; blue triangle: values for alloys and other coating materials; [ 51–55 ] red pentagon: values for alloys and other coating materials.…”

Section: Resultsmentioning

confidence: 99%

“…[ 9,11,51–58 ] a) The PIL possesses both stress reduction and increased osteointegration capability compared with the other published materials. Red five‐pointed star: values for the PIL; green circle (horizontal and vertical axis): values for the Ti implant, respectively; blue triangle: values for alloys and other coating materials; [ 51–55 ] red pentagon: values for alloys and other coating materials. [ 9,11,56–58 ] b) Elastic modulus vs hardness‐to‐elastic modulus ratio measured for the PIL, traditional biomedical implant, PDL, and chitosan.…”

Section: Resultsmentioning

confidence: 99%

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An Amorphous Peri‐Implant Ligament with Combined Osteointegration and Energy‐Dissipation

et al. 2021

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Progress toward developing metal implants as permanent hard‐tissue substitutes requires both osteointegration to achieve load‐bearing support, and energy‐dissipation to prevent overload‐induced bone resorption. However, in existing implants these two properties can only be achieved separately. Optimized by natural evolution, tooth‐periodontal‐ligaments with fiber‐bundle structures can efficiently orchestrate load‐bearing and energy dissipation, which make tooth–bone complexes survive extremely high occlusion loads (>300 N) for prolonged lifetimes. Here, a bioinspired peri‐implant ligament with simultaneously enhanced osteointegration and energy‐dissipation is presented, which is based on the periodontium‐mimetic architecture of a polymer‐infiltrated, amorphous, titania nanotube array. The artificial ligament not only provides exceptional osteoinductivity owing to its nanotopography and beneficial ingredients, but also produces periodontium‐similar energy dissipation due to the complexity of the force transmission modes and interface sliding. The ligament increases bone–implant contact by more than 18% and simultaneously reduces the effective stress transfer from implant to peri‐implant bone by ≈30% as compared to titanium implants, which as far as is known has not previously been achieved. It is anticipated that the concept of an artificial ligament will open new possibilities for developing high‐performance implanted materials with increased lifespans.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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An Amorphous Peri‐Implant Ligament with Combined Osteointegration and Energy‐Dissipation

et al. 2021

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“…Implantable biomedical devices often promote fibrous tissue encapsulation on the material-tissue interface. These adverse tissue responses are a critical consideration for the success and optimal integration of long-term implants [13][14][15] . Material surfaces that present biomimetic morphology like nanotube and nanofibers that provides nanoscale architectures have been shown to alter cell/biomaterial interactions 16 .…”

Section: Resultsmentioning

confidence: 99%

Coated Surface on Ti-30Ta Alloy for Biomedical Application: Mechanical and in-vitro Characterization

et al. 2020

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Several studies have been carried out to develop new materials for biomedical applications. Material surfaces that present biomimetic morphology like nanotubes or nanofibers that provides nanoscale architectures have been shown to alter cell/biomaterial interactions. The coated surface biomaterial with biocompatible polymers and nanotubes of TiO 2 is an alternative to improve osseointegration. The anodization process was performed to obtain nanotubes of TiO 2 covering the Ti-30Ta alloy surface and the electrospinning process has been used for producing polymer fibers. Characterization techniques such as scanning electron microscopy (SEM-FEG), X-ray diffraction analysis (X-rays), thermogravimetric analysis (TGA), Differential Scanning Calorimetry (DSC) and contact angle were used for samples analyses. Adult human adipose-derived stem cells (ADSCs) were used to investigate the cellular response and S. aureus antimicrobial activity on these coated surfaces. The results indicated that both surface modification treatment showed a favorable micro-environment for cells growth and proliferation such as adhesion, viability and morphology which is a desire property for an implant. In addition, the antimicrobial activity study presented both materials with similar growth of S. aureus. So, it can conclude nanotubes and nanofibers can be used at biomedical field and both present similar cell evaluation and antimicrobial activity results.

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“…As a result, 3D-printed titanium alloy implants with Sr 2+ coating are well suited for osteoporosis patients requiring joint replacement surgery. Shimizu et al andWei et al (2020, 2020) adopted a strategy of fixing Sr 2+ on the implant surface with micro-nano structure to enhance the early bone binding ability by continuously releasing Sr 2+ . Moreover, to achieve long-term release of Sr 2+ on the implant surface and obtain long-term bone induction ability, developed a coating combining Sr 2+ with zeolite to reduce the release rate of Sr 2+ due to the zeolite cation exchange function.…”

Section: Metal Coatingmentioning

confidence: 99%

Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization

Sheng

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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With the development of three-dimensional (3D) printed technology, 3D printed alloy implants, especially titanium alloy, play a critical role in biomedical fields such as orthopedics and dentistry. However, untreated titanium alloy implants always possess a bioinert surface that prevents the interface osseointegration, which is necessary to perform surface modification to enhance its biological functions. In this article, we discuss the principles and processes of chemical, physical, and biological surface modification technologies on 3D printed titanium alloy implants in detail. Furthermore, the challenges on antibacterial, osteogenesis, and mechanical properties of 3D-printed titanium alloy implants by surface modification are summarized. Future research studies, including the combination of multiple modification technologies or the coordination of the structure and composition of the composite coating are also present. This review provides leading-edge functionalization strategies of the 3D printed titanium alloy implants.

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Bioactive effects of strontium loading on micro/nano surface Ti6Al4V components fabricated by selective laser melting

Cited by 14 publications

References 40 publications

An Amorphous Peri‐Implant Ligament with Combined Osteointegration and Energy‐Dissipation

An Amorphous Peri‐Implant Ligament with Combined Osteointegration and Energy‐Dissipation

Coated Surface on Ti-30Ta Alloy for Biomedical Application: Mechanical and in-vitro Characterization

Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization

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