Bioactive Dimeric Acylphloroglucinols from the Mexican Fern Elaphoglossum paleaceum

Abstract

Plant photograph, TLC and HPLC analysis of the extracts, as well as EIMS, FABMS, NMR, and ECD materials of paleacenins A (1) and B (2) (PDF)■ AUTHOR INFORMATION

Natural Products Inhibitors of Monoamine Oxidases—Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma

“…Compound 130 exhibited IC50 values of 3.64 and 3.36 μM for human MAO-A and MAO-B, respectively; 131 exhibited IC50 values of 3.09 and 2.59 μM, respectively; and 132 exhibited IC50 values of 3.24 and 2.45 μM for MAO-A and MAO-B, respectively [180]. Paleacenins A 134 and B 135 are two novel acylphloroglucinols isolated from Elaphoglossum paleaceum rhizome, and these two undescribed compounds exhibited high MAO inhibition [181]. Compounds 134 and 135 showed to be a non-selective MAO inhibitor in rat brain mitochondria, and 134 exhibited IC50 values of 31.0 and 4.7 μM for MAO-A and-B, respectively.…”

“…Meanwhile, 135 showed IC50 values of 1.3 and 4.4 μM for MAO-A and -B, respectively. Besides their MAO inhibition, 134 and 135 also showed activity toward several cancer cell lines including the prostate, cervix, breast, and colon, denoting a multitarget effect for paleacinins [181]. Figure 12 shows the selected additional polyphenolic compound MAO inhibitors and Table 6 presents the IC50 values of selected phenol and polyphenolic compounds.…”

Phytochemical composition and the cholinesterase and xanthine oxidase inhibitory properties of seed extracts from theWashingtonia filiferapalm fruit

“…In recent years, researchers have been attempting to better valorise ora as a natural source of bioactive products. 1,2 Fruits or underutilized fruit species are receiving more attention, as they contain different phytochemicals that manifest many biological activities, 3 including the ability to inhibit several enzymatic targets. 4,5 Moreover, compared to metabolites in the edible portion of fruits, those present in seeds have an added value and good commercial potential as promising phytochemicals/antioxidants for use in food.…”