Bioactive constituents of Clausena lansium and a method for discrimination of aldose enantiomers

Monoterpenoid Coumarins from the Peels of Clausena lansium

“…By comparing the 1 H and 13 C NMR spectra of 1 with those of cnidimarin [24], a 5-substituted-8-hydroxylfuranocoumaryl moiety was confirmed. The signals in the 1 6 Hz, H-10′′) suggested the presence of an α,β-unsaturated γ-lactone moiety, which is a very common functional group in coumarins in the genus Clausena [18,19]. The fragments of C-1′′-C-2′′ and C-4′′-C-5′′ were confirmed by 1 H-1 H COSY correlations.…”

“…In addition, the fruits have high medicinal and edible values, which can be used for digestive disorders, abdominal pain, colic, phlegm, coughs, and asthma [4]. Previous phytochemical investigations of this genus, mainly on the roots, stems, seeds, and leaves, afforded a number of carbazole alkaloids, coumarins, and amide alkaloids with antimicrobial, cytotoxic, anti-HIV-1, anti-inflammatory, hypoglycemic, hepatoprotective, nootropic, anti-lipid peroxidation, and antioxidant activities [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. During the course of our effort to discover the bioactive constituents from the tropical medicinal plants in Hainan, two new coumarins, named clauslactone V (1) and clauslactone W (2), together with three known ones, clausenalansimin B (3), anisolactone (4), and wampetin (5) (l " Fig.…”

Total synthesis of naturally occurring 1-oxygenated carbazole alkaloids - clausine E, clausenapin, indizoline and formal synthesis of clausenaline D

“…Further studies showed that indizoline was also effective in causing significant-concentration dependent inhibition of tumor necrosis factor-α (TNF-α) which mediates the production of many cytokines during inflammation. 6 It also exhibited antitumor activity against human cancer cell lines. 8 Clausenapin (3) was isolated from the leaves of Clausena heptaphylla.…”

“…1,2 Moreover, there are substantial reports in the literature on the isolation of these alkaloids from various plant sources. [3][4][5][6][7][8][9][10][11][12][13] For example, clausine E (1) (Fig. 1), 3,4 isolated from the stem bark of Clausena excavata showed inhibition of rabbit platelet aggregation and vasocontraction.…”

“…1), 3,4 isolated from the stem bark of Clausena excavata showed inhibition of rabbit platelet aggregation and vasocontraction. 4 Indizoline (2) was isolated from various parts of Clausena lansium [5][6][7][8][9][10] and also from the roots of Clausena indica. 11 Various constituents of Clausena lansium along with indizoline showed a significant concentration-dependent inhibition of nitrite production in the case of RAW264.7, a mouse macrophage cell line used to model macrophage-mediated inflammatory events in vitro.…”