Bioactive constituents and pharmacological profile of willow-leaved Justicia: A review

Abstract

<i>Justicia gendarussa</i> Burm f., a member of Acanthaceae family, is indigenous to China and is widely dispersed throughout India, including the Andaman and Nicobar Islands. <i>J. gendarussa</i> is one of the most important plant species utilised in Ayurveda and Chinese medicine. Typically the plants are employed for different medicinal purposes. The plant possesses diverse biological activities like antiangiogenic, antibacterial, hepatoprotection, antifungal, antidepressant, sedative-hypnotic, anxiolytic, immunosuppressant, cytotoxicity, antioxidant and anthelmintic activities. Various chemical elements such as carbohydrates, alkaloids, polyphenolic chemicals, steroids, terpenoids, and saponins have been identified to contribute to these functions. The leaves were found to own most of the constituents like lupeol, friedelin, ß-sitosterol and aromatic amines. The current review emphases on Justicia gendarussa Burm's ethnobotanical significance, bioactive ingredients, and pharmacological profile.

A Panoramic Review of Traditional Use, Phytochemical Composition and Pharmacology of Justicia Gendarussa Burm f

“…In La Reunion the decoction of leaves is use as an stimulant and emetic. The roots alsoposses many medicinal properties (12). The extract obtain from the roots of willow leaved Justicia is prescribed for constipation, laxative action helps in easy bowel movement.…”

“…In vitro and in vivo models of carbon tetra chloride-induced liver injury demonstrated a strong hepatoprotective effect activity by the plant Justicia gendarussa's methanolic extract.Using primary rat hepatocytes and carbon tetra chloride as a hepatotoxin, researchers examined the in vitro hepatoprotective effect of Justicia gendarussa Burm (12). In addition to CCl4 (10 mM), different doses of plant extract (10, 50, and 100 ug/ml) and silymarin (100 ug/ml) were treated with the isolated primary rat hepatocytes (18).…”

Screening of Preliminary Phytochemicals, Molecular Identification, and Antimicrobial and Anti‐Inflammatory Activity of Justicia gendarussa

“…Te role of medicinal plants in drug manufacturing has been well documented since the beginning of time [1]. Generally, herbal medicines are more afordable with fewer side efects and are suggested to patients of all ages, and it is believed that more than 80% of the population in Asia and Africa still rely on medicinal plants to meet their basic healthcare needs [2][3][4][5]. Justicia gendarussa is a medicinal plant of the Acanthaceae family with a height of 1.5 to 2 meters that is widely cultivated in shade and damp places through cutting systems [6,7].…”

Phenolic and flavonoid content with agro morphological characters of 12 accessions of Justica gendarussa grew in Indonesia

“…The main active compounds of J. gendarussa that are also used as chemical markers are gendarusin A, gendarusin B, and the amide group (justidrusmides A-D) (Mnatsakanyan et al 2018). The J. gendarussa has been traditionally used to treat wounds, stomach pain, coughing, and asthma (Roy and Joseph 2022) and as a male contraceptive agent (Indrawati et al 2022). The pharmacological activity of J. gendarussa includes antioxidant, anti-inflammatory, hepatoprotective, cytotoxic, and antimicrobial (Phatangare et al 2017;Mahmud et al 2020).…”