Bioactive Constituents and Pharmacological Activities

Azeem, Uzma; Hakeem, Khalid Rehman; Ali, Mohammed Ashraf

doi:10.1007/978-3-030-58756-7_7

Cited by 2 publications

(2 citation statements)

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“…Patented products of active metabolites are mentioned in Table 2 . Dasgupta and Acharya (2019) and Azeem et al (2020) demonstrated that the poisonous mushroom Neonothopanus nimbi has aurisin A and aurisin K, which are effective against the Mycobacterium tuberculosis as well as Plasmodium falciparum ( Ajith and Janardhanan, 2007 ). The important effect of pharmacology as well as the physiological properties of mushrooms are the regulation of biorhythm, cure of several diseases, bioregulation (immune enhancement), improvement as well as prevention from life-threatening diseases including heart diseases, cancer, and cerebral stroke, and also the maintenance of homeostasis ( Wasser and Weis, 1999 ).…”

Section: Nutraceuticals and Bioactive Compoundsmentioning

confidence: 99%

Mushrooms as Potential Sources of Active Metabolites and Medicines

Bhambri¹,

Srivastava

Mahale

et al. 2022

Front. Microbiol.

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BackgroundMushrooms exist as an integral and vital component of the ecosystem and are very precious fungi. Mushrooms have been traditionally used in herbal medicines for many centuries.Scope and ApproachThere are a variety of medicinal mushrooms mentioned in the current work such as Agaricus, Amanita, Calocybe, Cantharellus, Cordyceps, Coprinus, Cortinarius, Ganoderma, Grifola, Huitlacoche, Hydnum, Lentinus, Morchella, Pleurotus, Rigidoporus, Tremella, Trametes sp., etc., which play a vital role in various diseases because of several metabolic components and nutritional values. Medicinal mushrooms can be identified morphologically on the basis of their size, color (white, black, yellow, brown, cream, pink and purple-brown, etc.), chemical reactions, consistency of the stalk and cap, mode of attachment of the gills to the stalk, and spore color and mass, and further identified at a molecular level by Internal Transcribed Spacer (ITS) regions of gene sequencing. There are also other methods that have recently begun to be used for the identification of mushrooms such as high-pressure liquid chromatography (HPLC), nuclear magnetic resonance spectroscopy (NMR), microscopy, thin-layer chromatography (TLC), DNA sequencing, gas chromatography-mass spectrometry (GC-MS), chemical finger printing, ultra-performance liquid chromatography (UPLC), fourier transform infrared spectroscopy (FTIR), liquid chromatography quadrupole time-of-flight mass spectrometry (LCMS-TOF) and high-performance thin-layer chromatography (HPTLC). Lately, the matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) technique is also used for the identification of fungi.Key Finding and ConclusionMedicinal mushrooms possess various biological activities like anti-oxidant, anti-cancer, anti-inflammatory, anti-aging, anti-tumor, anti-viral, anti-parasitic, anti-microbial, hepatoprotective, anti-HIV, anti-diabetic, and many others that will be mentioned in this article. This manuscript will provide future direction, action mechanisms, applications, and the recent collective information of medicinal mushrooms. In addition to many unknown metabolites and patented active metabolites are also included.

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Section: Nutraceuticals and Bioactive Compoundsmentioning

confidence: 99%

Mushrooms as Potential Sources of Active Metabolites and Medicines

Bhambri¹,

Srivastava

Mahale

et al. 2022

Front. Microbiol.

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“…Six lanostane triterpenes from Ganoderma lucidum have been identified to possess in-vitro antiplasmodial activity 58, 89 . Aurisin A and aurisin K from poisonous mushroom Neonothopanus nimbi were found to be effective against Plasmodium falciparum and Mycobacterium tuberculosis 58,90 . Apart from these, several mushroom secondary metabolites have been studied for their anti-parasitic activities.…”

Section: 3mentioning

confidence: 99%

Untitled

2021

IJPSR

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Since ancient times, humans have always been captivated by nature and have explored natural products. To combat against novel emerging and reemerging diseases and tremendous side effects imposed by recent therapies, scientists have again taken an interest in natural resources. To date, plants have been the major source of natural bioactive compounds, but recently fungi have got more attention. Amongst fungi, edible and medicinal mushrooms have come out as a rich source of bioactive metabolites. Since long back, they are being consumed heavily because of their outstanding flavour, aroma, nutritional value, and medicinal properties. Both edible, as well as medicinal mushrooms, synthesize bioactive compounds known as secondary metabolites i.e., polysaccharides, steroids, terpenes as well as peptides. Such metabolites possess many medicinal properties like anti-oxidant, anti-tumor, anti-diabetic, anti-cancer, antiageing, and also anti-obesity. Furthermore, mushroom secondary metabolites are prioritized over other natural compounds due to their non-toxic nature and low or no side effects. This review mainly covers sources and types of secondary mushroom metabolites and their therapeutic applications.

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Bioactive Constituents and Pharmacological Activities

Cited by 2 publications

References 255 publications

Mushrooms as Potential Sources of Active Metabolites and Medicines

Mushrooms as Potential Sources of Active Metabolites and Medicines

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