Bioactive constituents and medicinal importance of genus Alnus

Sati, S. C.; Sati, Nitin; Op, Sati

doi:10.4103/0973-7847.91115

Cited by 88 publications

(70 citation statements)

References 33 publications

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“…The plants of Alnus genus contained various types of plant secondary metabolites including terpenoids, flavonoids, diarylheptanoids, phenols, steroids, tannins, and many others (Sati et al, 2011). Martineau et al (2010) reported the results of a classical bioassay-guided fractionation approach aimed at identifying the active principles responsible for the inhibition of adipogenesis, as measured using triglyceride accumulation in the 3T3-L1 adipocyte model cell line.…”

Section: Discussionmentioning

confidence: 99%

“…Among them, diarylheptanoids (hirsutenone, oregonin, (5S)- O-methylhirsutanonol, 2-oxatrycyclo[13.2.2.13,7]eicosa-3,5,7(20),15,17,18-hexaen-10-16-diol, 2-oxatrycyclo [13.2.2.13,7]eicosa-3,5,7-(20),15,17,18-hexaen-10-one, garugamblin-3, acerogenin l, etc.) are highly potent bioactivities (Sati et al, 2011). Middleton et al (2005) tested antibacterial activity of A. glutinosa.…”

Section: Discussionmentioning

confidence: 99%

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Antimicrobial and cytotoxic activities of Alnus rugosa L. aerial parts and identification of the bioactive components

Rashed

Ćirić

Glamočlija

et al. 2014

Industrial Crops and Products

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a b s t r a c tThis present investigation was undertaken to study antimicrobial and cytotoxic activities of dichloromethane, ethyl acetate, and methanol 80% extracts from Alnus rugosa L. aerial parts, as well investigate the bio-active compounds of each extract. Antimicrobial activity of the mentioned extracts against various bacteria and fungi using microdilution method, and cytotoxicity against five different human tumor cell lines, and in a non-tumor liver cells primary culture were tested. Extracts were subjected to phytochemical analysis and column chromatography eluted with different solvents, n-hexane, dichloromethane, ethyl acetate, and methanol gradually. The results showed that the extracts had a significant antimicrobial activity against all the tested bacteria and fungi, and proved a significant cytotoxic effect. Methanol 80% extract exhibited the highest antibacterial effect, and ethyl acetate extract was the most active as antifungal agent while dichloromethane extract showed the lowest antifungal effect. Dichloromethane extract was the most active against all the tested tumor cell lines. Chromatographic separation of dichloromethane extract of A. rugosa aerial parts resulted in the isolation and identification of ␤-sitosterol, ␤-sitosterol 3-O-␤-glucoside and apigenin, while from ethyl acetate extract, diosmetin, naringenin, luteolin, and luteolin 7-O-␤-glucoside were identified, and from methanol 80% extract, quercetin 3-O-␣-rhamnoside, isorhamnetin 3-O-␤-glucoside and isorhamnetin 3-O-␤-glucoside 7-O-␣-rhamnoside were identified. In conclusion, the present research provided significant information about antimicrobial and cytotoxic activities and compounds isolated from A. rugosa aerial parts extracts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antimicrobial and cytotoxic activities of Alnus rugosa L. aerial parts and identification of the bioactive components

Rashed

Ćirić

Glamočlija

et al. 2014

Industrial Crops and Products

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“…Various Alnus species have been investigated frequently to examine the potential biological activities and structures of individual extractible compounds (Roze et al 2011;Sati et al 2011;Telysheva et al 2011). However, information about the influence of extractives in black alder on technological processes is sparse and fragmentary (Bauch 1984).…”

Section: Introductionmentioning

confidence: 99%

Yield of Stirred Cold Maceration and Extraction of Milled European Black Alder Wood and Bark using Different Solvents

Klarić¹,

Oven²,

Gorišek³

et al. 2016

BioResources

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a Wood extractives, especially polyphenols, have great influence on the xylem colour of many wood species, which affects the success of hydrothermal wood processing, such as wood drying. One such wood species is European black alder (Alnus glutinosa (L.) Gaertn.), which is prone to forming intense and uneven reddish-orange or reddish-brown discolourations immediately upon harvesting and processing. However, there is lack of published scientific data on the wood and bark extractives of black alder, as well as the most suitable solvents to extract them. In this work, total soluble extractives, phenols, and flavonoids have been quantified in the wood and bark of black alder. Furthermore, the influence of four different polar organic solvents and deionized water on extractives removal yields has been measured. It was found that the bark has much higher levels of extractives as compared to the wood. Furthermore, it has been found that the highest extractive yields were obtained by using methanol as the extraction solvent for all observed compound group classifications.

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“…Peak identified with molecular mass of 280 indicates the presence of yashabushiketol, which is a diarylheptanoid. Asakawa et al 43 stated that yashabushiketol was isolated from buds of Alnus sieboldiana while this compound separated from Alnus firma was reported to be effective against HIV virus 44 .…”

Section: Gc-ms Analysismentioning

confidence: 99%

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2016

IJPSR

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Since, the free radicals induced oxidative stress is posing threat present researchers are focusing on natural sources that could serve as antioxidants to combat the oxidative damage mediated diseases such as diabetes, atherosclerosis and cancer. In this context, present study was carried out to investigate the botanical characters, chemical composition and in vitro antioxidant potential of Jatropha gossypifolia L. so as to provide scientific evidences for the medicinal properties claimed on this plant. Microscopic studies were conducted on both entire leaf and leaf powder, the elemental composition of leaf powder was investigated. Extracts of J. gossypifolia leaf was prepared with hexane, chloroform, ethyl acetate, ethanol and water and screened for the detection of various phytochemicals and the major phytochemical compounds present were identified through HPTLC and GC-MS analysis. In vitro antioxidant activity of solvent extracts was evaluated through reducing power and DPPH radical scavenging assays. Phytochemical screening revealed the presence of phenols, flavones, glycosides, steroids, alkaloids and quinines in the ethanolic extract. Quantification of phytochemicals showed 3.35 mg/kg of alkaloids, 3.60 mg/kg flavonoids, 0.22 mg/kg tannins and 0.12 mg/kg glycosides. Elemental composition revealed the existence of high level of calcium (3.89%) and iron (85 ppm), which have clinical importance. Presence of alkaloids, quercetin, and fraxetin were confirmed with HPTLC analysis. Among the different solvent extracts, ethyl acetate exhibited higher antioxidant activity. Presence of phytochemicals such as p-Cymene, Fumaric acid, 12-Octadecanoic acid, 1-Heptadecanol, and Yashabushiketol were confirmed in this plant through GC-MS analysis. Botanical and chemical standards were determined for J. gossypifolia leaf through the present investigation and the results of in vitro antioxidant assays gives the scientific evidence for the health benefits and medicinal effects claimed on J. gossypifolia.

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Bioactive constituents and medicinal importance of genus Alnus

Cited by 88 publications

References 33 publications

Antimicrobial and cytotoxic activities of Alnus rugosa L. aerial parts and identification of the bioactive components

Antimicrobial and cytotoxic activities of Alnus rugosa L. aerial parts and identification of the bioactive components

Yield of Stirred Cold Maceration and Extraction of Milled European Black Alder Wood and Bark using Different Solvents

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