Bioactive Compounds Produced by Endophytic Microorganisms Associated with Bryophytes—The “Bryendophytes”

Abstract

The mutualistic coexistence between the host and endophyte is diverse and complex, including host growth regulation, the exchange of substances like nutrients or biostimulants, and protection from microbial or herbivore attack. The latter is commonly associated with the production by endophytes of bioactive natural products, which also possess multiple activities, including antibacterial, insecticidal, antioxidant, antitumor, and antidiabetic properties, making them interesting and valuable model substances for future development into drugs. The endophytes of higher plants have been extensively studied, but there is a dearth of information on the biodiversity of endophytic microorganisms associated with bryophytes and, more importantly, their bioactive metabolites. For the first time, we name bryophyte endophytes “bryendophytes” to elaborate on this important and productive source of biota. In this review, we summarize the current knowledge on the diversity of compounds produced by endophytes, emphasizing bioactive molecules from bryendophytes. Moreover, the isolation methods and biodiversity of bryendophytes from mosses, liverworts, and hornworts are described.

Draft Genome Sequence of Pantoea sp. Strain MHSD4, a Bacterial Endophyte With Bioremediation Potential

“…In this study, the endophyte was re-cultured on tryptic soy agar (TSA) for 48 hours at 28°C. 19 The total genomic DNA of the bacterial culture was extracted from pure colonies using the Nucleospin ® Microbial DNA extraction kit (Macherey-Nagel, Germany) according to the manufacturer’s protocol. The extracted DNA quality and quantity was determined using the Implen Nanophotometer N60 (Implen GmbH, Germany).…”

Analysis of Marchantia polymorpha–microorganism interactions: basis for understanding plant–microbe and plant–pathogen interactions

“…The diversity and biological activity of endophytic microorganisms isolated from bryophytes represent topics of significant scientific interest. In 2023, the term “bryendophytes” was coined to collectively refer to these microorganisms, mainly bacteria and fungi ( Stelmasiewicz et al., 2023a ). Bacteria play a key role in the presence and diversity of endophytes across various habitats, because of the different biological activities they engage in during their interactions with bryophytes.…”

“…Of these 82 articles, 60 were not related to the subject, and two other articles were reviews; therefore, 20 articles were included in the review. This review focuses on the use of M. polymorpha as a model plant in evolutionary studies with microorganisms ( Poveda, 2020a ) and on the identification and metabolic characterization of endophytic microorganisms associated with bryophytes or “bryendophytes” ( Stelmasiewicz et al., 2023a ). On the other hand, after searching for keywords in “Title, Abstract and Keywords,” without time restrictions, a total of 95 results were retrieved in Scopus (search conducted on 7 July 2023).…”

Antioxidant Activity of Endophytic Fungi Isolated from Cashew (Anacardium occidentale) Leaves

“…25,26 One of the most important sources for the development of new pharmaceuticals is natural compounds obtained from endophytic fungi. [27][28][29][30][31] According to several research, the majority of secondary metabolites derived from endophytic fungus have a particular chemical structure, either through the creation of new molecules that are distinct from their hosts or secondary metabolites that are similar to their hosts' secondary metabolites. 29,[32][33][34][35][36] The culinary, agricultural, and pharmaceutical industries may all benefit from the abundance of beneficial secondary metabolites that are produced by endophytic fungus.…”

“…[27][28][29][30][31] According to several research, the majority of secondary metabolites derived from endophytic fungus have a particular chemical structure, either through the creation of new molecules that are distinct from their hosts or secondary metabolites that are similar to their hosts' secondary metabolites. 29,[32][33][34][35][36] The culinary, agricultural, and pharmaceutical industries may all benefit from the abundance of beneficial secondary metabolites that are produced by endophytic fungus. These compounds have antibacterial, antifungal, , antioxidant, immune-suppressing, antiparasiticanti-inflammatory, antiviral, and anticancer properties.…”