Bioactive Compounds Produced by Antarctic Filamentous Fungi

Vaca, Inmaculada; Chávez, Renato

doi:10.1007/978-3-030-18367-7_12

Cited by 9 publications

(4 citation statements)

References 57 publications

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“…Previously unknown species are frequently encountered, often with potential biotechnological interest. For example, unusual biochemical pathways have been reported from Antarctic strains, allowing them to generate new antimicrobial, herbicidal, and antitumor compounds [ 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Growth Forms and Functional Guilds Distribution of Soil Fungi in Coastal Versus Inland Sites of Victoria Land, Antarctica

Canini

Buzzini

Turchetti

et al. 2021

Biology

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In Victoria Land, Antarctica, ice-free areas are restricted to coastal regions and dominate the landscape of the McMurdo Dry Valleys. These two environments are subjected to different pressures that determine the establishment of highly adapted fungal communities. Within the kingdom of fungi, filamentous, yeasts and meristematic/microcolonial growth forms on one side and different lifestyles on the other side may be considered adaptive strategies of particular interest in the frame of Antarctic constraints. In this optic, soil fungal communities from both coastal and Dry Valleys sites, already characterized thorough ITS1 metabarcoding sequencing, have been compared to determine the different distribution of phyla, growth forms, and lifestyles. Though we did not find significant differences in the richness between the two environments, the communities were highly differentiated and Dry Valleys sites had a higher evenness compared to coastal ones. Additionally, the distribution of different growth forms and lifestyles were well differentiated, and their diversity and composition were likely influenced by soil abiotic parameters, among which soil granulometry, pH, P, and C contents were the potential main determinants.

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Section: Introductionmentioning

confidence: 99%

Growth Forms and Functional Guilds Distribution of Soil Fungi in Coastal Versus Inland Sites of Victoria Land, Antarctica

Canini

Buzzini

Turchetti

et al. 2021

Biology

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“…In addition to enzymes, fungi are a rich reservoir of different classes of secondary metabolites, such as terpenoids, polyketides, alkaloids, polyacetylenes with demonstrated antiviral, antibacterial, antifungal, antitumoral, herbicidal and antiprotozoal activities. These molecules play a pivotal role in the inter-and intra-specific interactions within the soil microbial communities and provide them competitive advantages over other microorganisms [11,51]. A list of bioactive compounds retrieved from Antarctic soil fungi, grouped according to their biological activity is reported in Table 2.…”

Section: Other Bioactive Compoundsmentioning

confidence: 99%

Extracellular Enzymes and Bioactive Compounds from Antarctic Terrestrial Fungi for Bioprospecting

Zucconi

Canini

Temporiti

et al. 2020

IJERPH

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Antarctica, one of the harshest environments in the world, has been successfully colonized by extremophilic, psychrophilic, and psychrotolerant microorganisms, facing a range of extreme conditions. Fungi are the most diverse taxon in the Antarctic ecosystems, including soils. Genetic adaptation to this environment results in the synthesis of a range of metabolites, with different functional roles in relation to the biotic and abiotic environmental factors, some of which with new biological properties of potential biotechnological interest. An overview on the production of cold-adapted enzymes and other bioactive secondary metabolites from filamentous fungi and yeasts isolated from Antarctic soils is here provided and considerations on their ecological significance are reported. A great number of researches have been carried out to date, based on cultural approaches. More recently, metagenomics approaches are expected to increase our knowledge on metabolic potential of these organisms, leading to the characterization of unculturable taxa. The search on fungi in Antarctica deserves to be improved, since it may represent a useful strategy for finding new metabolic pathways and, consequently, new bioactive compounds.

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“…Notably, marine natural products (MNP) from fungi represent nearly half of all reported MNP [ 1 , 2 ]. Fungi isolated from Antarctic environments are not an exception and are also well-known as producers of bioactive metabolites [ 3 , 4 ]. Cadophora is a worldwide ubiquitous genus with 43 species nowadays [ 5 ] some of which, including C. malorum , were reported from Antarctica locations [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Cyclic heptapeptides with metal binding properties isolated from the fungus Cadophora malorum from Antarctic soil

Donalle

Martorell

Siless

et al. 2022

Nat. Prod. Bioprospect.

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The Antarctic fungus Cadophora malorum produces previously undescribed cyclic heptapeptides (cadophorin A and B) containing an anthranilic acid residue. The planar structure of these peptides was determined by high-resolution mass spectrometry combined with extensive 1D and 2D NMR spectroscopy. The absolute configuration of the amino acids was determined by Marfey’s method, with HPLC analysis of FDVA (Nα-(2,4-dinitro-5-fluorphenyl)-l-valinamide) derivatives making use of a PFP column. Remarkably, cadophorin 2 possesses both the uncommon d-Ile and d-allo-Ile in its structure. The peptides have metal binding properties as shown by LCMS with post column addition of metal salt solutions. These results were supported by DFT calculations. Graphical Abstract

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Bioactive Compounds Produced by Antarctic Filamentous Fungi

Cited by 9 publications

References 57 publications

Growth Forms and Functional Guilds Distribution of Soil Fungi in Coastal Versus Inland Sites of Victoria Land, Antarctica

Growth Forms and Functional Guilds Distribution of Soil Fungi in Coastal Versus Inland Sites of Victoria Land, Antarctica

Extracellular Enzymes and Bioactive Compounds from Antarctic Terrestrial Fungi for Bioprospecting

Cyclic heptapeptides with metal binding properties isolated from the fungus Cadophora malorum from Antarctic soil

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