Bioactive Compounds of Sea Anemones: A Review

Thangaraj, S.; Bragadeeswaran, S.; Gokula, V.

doi:10.1007/s10989-018-9786-6

Cited by 11 publications

(5 citation statements)

References 84 publications

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“…Cereus sinensis belonging to Actiniaria, HormathiidaeCarlgren, CalliactisVerrill grown mainly along the Pacific coast ( 11 ). At present, many substances with toxic or important functions, such as anti-cancer, antibacterial, anticoagulant, and anti-inflammatory, have been found and extracted from sea anemones ( 12 – 14 ). Moreover, the research on sea anemone mainly focused on the field of proteins, polypeptides, the toxins structure and biological activities ( 15 – 18 ).…”

Section: Introductionmentioning

confidence: 99%

Cereus sinensis Polysaccharide Alleviates Antibiotic-Associated Diarrhea Based on Modulating the Gut Microbiota in C57BL/6 Mice

et al. 2021

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The present study investigated whether the purified polysaccharide from Cereus sinensis (CSP-1) had beneficial effects on mice with antibiotic-associated diarrhea (AAD). The effects of CSP-1 on gut microbiota were evaluated by 16S rRNA high-throughput sequencing. Results showed that CSP-1 increased the diversity and richness of gut microbiota. CSP-1 enriched Phasecolarctobacterium, Bifidobacterium and reduced the abundance of Parabacteroides, Sutterella, Coprobacillus to near normal levels, modifying the gut microbial community. Microbial metabolites were further analyzed by gas chromatography-mass spectrometry (GC-MS). Results indicated CSP-1 promoted the production of various short-chain fatty acids (SCFAs) and significantly improved intestinal microflora dysfunction in AAD mice. In addition, enzyme linked immunosorbent assay and hematoxylin-eosin staining were used to assess the effects of CSP-1 on cytokine levels and intestinal tissue in AAD mice. Results demonstrated that CSP-1 inhibited the secretion of interleukin-2 (IL-2), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) and improved the intestinal barrier. Correspondingly, the daily records also showed that CSP-1 promoted recovery of diarrhea status score, water intake and body weight in mice with AAD. In short, CSP-1 helped alleviate AAD by regulating the inflammatory cytokines, altering the composition and richness of intestinal flora, promoting the production of SCFAs, improving the intestinal barrier as well as reversing the dysregulated microbiota function.

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Section: Introductionmentioning

confidence: 99%

Cereus sinensis Polysaccharide Alleviates Antibiotic-Associated Diarrhea Based on Modulating the Gut Microbiota in C57BL/6 Mice

et al. 2021

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“…There is also a growing interest in cnidarian venoms as a potential resource for drug discovery, particularly the neurotoxin-rich venoms of sea anemones [ 28 , 29 , 30 ]. One of the best studied therapeutic proteins derived from a cnidarian toxin is an analogue of a potassium Kv1.3 channel blocker isolated from the sun sea anemone ( Stichodactyla helianthus ) called ShK [ 31 ], which completed Phase 1b trials for autoimmune diseases [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic Analysis of Four Cerianthid (Cnidaria, Ceriantharia) Venoms

et al. 2020

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Tube anemones, or cerianthids, are a phylogenetically informative group of cnidarians with complex life histories, including a pelagic larval stage and tube-dwelling adult stage, both known to utilize venom in stinging-cell rich tentacles. Cnidarians are an entirely venomous group that utilize their proteinaceous-dominated toxins to capture prey and defend against predators, in addition to several other ecological functions, including intraspecific interactions. At present there are no studies describing the venom for any species within cerianthids. Given their unique development, ecology, and distinct phylogenetic-placement within Cnidaria, our objective is to evaluate the venom-like gene diversity of four species of cerianthids from newly collected transcriptomic data. We identified 525 venom-like genes between all four species. The venom-gene profile for each species was dominated by enzymatic protein and peptide families, which is consistent with previous findings in other cnidarian venoms. However, we found few toxins that are typical of sea anemones and corals, and furthermore, three of the four species express toxin-like genes closely related to potent pore-forming toxins in box jellyfish. Our study is the first to provide a survey of the putative venom composition of cerianthids and contributes to our general understanding of the diversity of cnidarian toxins.

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“…In 2019-2021 a large number of reviews were published that covered general and/or specific areas of marine preclinical pharmacology: (a) marine pharmacology and marine pharmaceuticals: marine natural products and their relevant biological activities published in 2019, 2020 and 2021 [202]; advances in marine natural products therapeutic potential [203]; polar marine terpenoids and their potential for drug discovery [204][205][206]; bioactive properties of marine phenolics [207]; chemistry and biological activities of marine flavonoids [208]; marine-derived spirotetronates and potential pharmaceutical applications [209]; bioactivities of marine-derived hydroperoxides [210]; marinederived macrocyclic alkaloids as a potential source of drugs [211]; pharmacology of thiazole-based marine-derived peptides [212]; marine meroterpenoids and cembranoids biological activities [213,214]; marine-derived macrolides chemical and biological diversity [215]; pharmacology of cyanobacterial-derived natural products [216][217][218][219][220][221]; marine natural products from microalgae: anomics overview [222,223]; pharmacological potential of macroalgae natural products [224][225][226][227][228][229][230][231]; bioactive compounds from Bryozoa and Cnidaria [232][233][234][235]; genus Didemnum secondary metabolites pharmacological properties [236]; marine fungi-derived bioactive compounds…”

Section: Reviews On Marine Pharmacology and Pharmaceuticalsmentioning

confidence: 99%

Marine Pharmacology in 2019‐2021: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti‐Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Mayer,

Swanson-Mungerson

et al. 2024

Preprint

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The current 2019-2021 marine pharmacology literature review provides a continuation of previous reviews covering the period 1998 to 2018. Preclinical marine pharmacology research during 2019-2021 was published by researchers in 42 countries and contributed novel mechanism of action pharmacology for 171 structurally characterized marine compounds. The peer-reviewed marine natural products pharmacology literature reported antibacterial, antifungal, antiprotozoal, antituberculosis,and antiviral mechanism of action studies for 49 compounds, 87 compounds with antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while another group of 51 compounds demonstrated novel miscellaneous mechanisms of action, which upon further investigation, may contribute to several pharmacological classes. Thus, in 2019-2021, a very active preclinical marine natural product pharmacology pipeline provided novel mechanism of actions as well as new lead chemistry for the clinical marine pharmaceutical pipeline targeting the therapy of several disease categories.

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Bioactive Compounds of Sea Anemones: A Review

Cited by 11 publications

References 84 publications

Cereus sinensis Polysaccharide Alleviates Antibiotic-Associated Diarrhea Based on Modulating the Gut Microbiota in C57BL/6 Mice

Cereus sinensis Polysaccharide Alleviates Antibiotic-Associated Diarrhea Based on Modulating the Gut Microbiota in C57BL/6 Mice

Transcriptomic Analysis of Four Cerianthid (Cnidaria, Ceriantharia) Venoms

Marine Pharmacology in 2019‐2021: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti‐Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

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