Bioactive compounds fromRhodiola rosea (Crassulaceae)

Ming, Dong Sheng; Hillhouse, Brian J.; Guns, Emma S. Tomlinson; Eberding, Andy; Xie, Sherwin; Vimalanathan, Selvarani; Towers, G.H.N.

doi:10.1002/ptr.1597

Cited by 99 publications

(64 citation statements)

References 20 publications

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“…Rhodiola rosea L. (Crassulaceae) (goldenroot or roseroot) grows in arctic and mountainous regions (Ming et al 2005). It has a long and global history of use (Panossian et al 2010), and is a popular natural remedy with a worldwide distribution.…”

Section: Introductionmentioning

confidence: 99%

In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products

Thu

Nilsen

Hellum

2016

Pharmaceutical Biology

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Context: Rhodiola rosea L. (Crassulaceae) products are popular natural remedies with a worldwide distribution. Recent studies have revealed potent CYP inhibition by R. rosea extracts both in vitro and in vivo, but information on in vitro CYP inhibition by commercial products are lacking. Variations in commercial R. rosea product quality have also been published. Objective: This study evaluates the variation of in vitro CYP inhibition potential and product quality of six commercially available R. rosea products. Materials and methods: Human CYPs isolated from baculovirus-infected cell system were incubated with testosterone (CYP3A4), dextromethorphan (CYP2D6) or phenacetin (CYP1A2). Positive CYP inhibitors ketoconazole (CYP3A4), quinidine (CYP2D6) and b-naphtoflavone (CYP1A2) were used as controls. Quantification of rosavin, rosarin, rosin, tyrosol and salidroside were used to evaluate R. rosea content. Results: IC 50 values ranged from 7.2-106.6 lg/mL for CYP3A4, 13.0-186.1 lg/mL for 2D6 and 10.7-116.0 lg/mL for 1A2. The tincture formulation of R. rosea was the strongest inhibitor giving the lowest IC 50 values of 7.2 ± 0.7, 13 ± 1.7 and 10.7 ± 5.6 lg/mL, respectively. CYP3A4 was significantly more inhibited by the different products than CYP1A2 (p < .05). One of the six products did not contain any rosavin, rosarin or rosin and is not a R. rosea product. Constituent concentrations were not linked to enzyme inhibition. Discussion and conclusion: The present results show a large variation in inhibitory potential between the products. Several of the products demonstrate similar inhibition levels as the product Arctic Root already proven to inhibit CYP enzyme activity in man.ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products

Thu

Nilsen

Hellum

2016

Pharmaceutical Biology

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“…Some preclinical and clinical studies of R. rosea extracts have provided evidence for a number of pharmacological activities, including adaptogenic, antistress, antihypoxic, antioxidant, anticancer, learning and memory enhancing and immune and sexual stimulating effects (Petkov et al, 1986;Darbinyan et al, 2000;Ming et al, 2005;fragmentary and often not comparable due to the various extracts and different modalities of their administration (single or repeated); many are also not available in English language journals.…”

Section: Introductionmentioning

confidence: 99%

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Perfumi

Mattioli

2006

Phytotherapy Research

150

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Rhodiola rosea L., or 'golden root', is a popular plant in traditional medicine in Eastern Europe and Asia, with a reputation for improving depression, enhancing work performance, eliminating fatigue and treating symptoms of asthenia subsequent to intense physical and psychological stress. Due to these therapeutic properties, R. rosea is considered to be one of the most active adaptogenic drugs. To confirm and extend results obtained in the few preclinical and clinical studies available in English language journals, the purpose of the present study was to re-investigate the effects produced by a single oral administration of an R. rosea hydroalcohol extract (containing 3% rosavin and 1% salidroside) on the central nervous system in mice. The extract was tested on antidepressant, adaptogenic, anxiolytic, nociceptive and locomotor activities at doses of 10, 15 and 20 mg/kg, using predictive behavioural tests and animal models. The results show that this R. rosea extract significantly, but not dose-dependently, induced antidepressant-like, adaptogenic, anxiolytic-like and stimulating effects in mice. This study thus provides evidence of the efficacy of R. rosea extracts after a single administration, and confirms many preclinical and clinical studies indicating the adaptogenic and stimulating effects of such R. rosea extracts. Moreover, antidepressant-like and anxiolytic-like activities of R. rosea were shown in mice for the first time.

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“…It has long been known to have adaptogenic properties (Brekhman & Dardymov, 1969). Recently, researchers have found that it can elevate concentrations of norepinephrine, dopamine, and serotonin in the brain, act as a nicotinic cholinergic agonist in the central nervous system, reduce the level of C-reactive protein and creatinine kinase in the blood, increase the ATP content in the muscle mitochondria, and has antiarrhythmic activity, anti-prostate cancer activity, and antibacterial activity (Maslov et al, 1998;Abidov et al, 2003Abidov et al, , 2004Ming et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Salidroside on Hypoxia/Reoxygenation Injury by Sodium Hydrosulfite in PC12 Cells

Chen

Lü

Wang

et al. 2007

Pharmaceutical Biology

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Hypoxia=reoxygenation causes cellular injury and death associated with many pathophysiologic conditions, including respiratory disorders, myocardial ischemia, and tumour progression diseases. Neuronal pheochromocytoma (PC12) cells are widely used as a model system for neurologic research and are subject to chemical hypoxia induced with sodium hydrosulfite (Na 2 S 2 O 4 ), a common oxygen-consuming agent. Salidroside, which is the main active component of the famous traditional Chinese herb Rhodiola rosea L. (Crassulaceae), has been proved to possess many bioactivities. In this article, we studied the protective effects of salidroside on hypoxia= reoxygenation injury in PC12 cells induced by Na 2 S 2 O 4 . Cultures of PC12 cells were exposed for 1 h to 10 mM Na 2 S 2 O 4 for hypoxia, followed by reoxygenation for 2 h. The results showed that salidroside was very stable in medium and was not harmful to PC12 cells at the experimental concentrations of 0 $ 200 mg=mL. The cytoprotection by salidroside was dose-dependent, and the cell viability was 41.8 AE 5.7%, 62.4 AE 4.1%, and 92.2 AE 3.7% at 0, 50, and 100 mg=mL of salidroside, respectively. The level of released LDH significantly decreased from 513.5 AE 5.5% (without salidroside) to 258.1 AE 6.3% (with 100 mg=mL salidroside). Flow cytometry was performed to measure apoptotic rate. The results of flow cytometry assay indicated that the apoptotic rate was 17.0 AE 1.2% after hypoxia=reoxygenation injury. When the cells were treated with salidroside 12.5, 50 and 100 mg=mL, the apoptotic rate was 9.5 AE 0.9%, 7.4 AE 0.5%, and 4.5 AE 0.4%, respectively. In addition, our results were confirmed by inspection of cell morphology of PC12 cells. Treatment with salidroside (12.5, 50, 100 mg=mL) significantly prevented the cells from morphologic changes. All the above results showed salidroside could effectively protect PC12 cell against hypoxia=reoxygenation injury.

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Bioactive compounds fromRhodiola rosea (Crassulaceae)

Cited by 99 publications

References 20 publications

In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products

In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Protective Effects of Salidroside on Hypoxia/Reoxygenation Injury by Sodium Hydrosulfite in PC12 Cells

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