Bioactive Compounds from the Zingiberaceae Family with Known Antioxidant Activities for Possible Therapeutic Uses

Alolga, Raphael N.; Wang, Feizuo; Zhang, Xinyao; Li, Jia; Tran, Lam‐Son Phan; X, Yin

doi:10.3390/antiox11071281

Cited by 17 publications

(13 citation statements)

References 146 publications

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“…If not neutralized, these FRs, such as ROS or RNS, interact with cells, causing oxidative damage, which can contribute to cellular aging and the development of chronic diseases, such as cancer [ 64 ], inflammatory diseases [ 65 ], neurodegenerative diseases [ 66 ], and cardiovascular diseases [ 67 ]. This antioxidant property of ginger is due to the presence of antioxidant compounds, such as gingerols (6-gingerol, 8-gingerol, and 10-gingerol), shogaols (6-shogaol, 8-shogaol, and 10-shogaol), flavonoids, and phenolic acids [ 68 ].…”

Section: Antioxidant Activity Of Zingiberaceae Familymentioning

confidence: 99%

Antioxidant Activity in Extracts from Zingiberaceae Family: Cardamom, Turmeric, and Ginger

et al. 2023

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An increase in life expectancy leads to a greater impact of chronic non-communicable diseases. This is even more remarkable in elder populations, to whom these become main determinants of health status, affecting mental and physical health, quality of life, and autonomy. Disease appearance is closely related to the levels of cellular oxidation, pointing out the importance of including foods in one’s diet that can prevent oxidative stress. Previous studies and clinical data suggest that some plant-based products can slow and reduce the cellular degradation associated with aging and age-related diseases. Many plants from one family present several applications that range from the food to the pharmaceutical industry due to their characteristic flavor and scents. The Zingiberaceae family, which includes cardamom, turmeric, and ginger, has bioactive compounds with antioxidant activities. They also have anti-inflammatory, antimicrobial, anticancer, and antiemetic activities and properties that help prevent cardiovascular and neurodegenerative diseases. These products are abundant sources of chemical substances, such as alkaloids, carbohydrates, proteins, phenolic acids, flavonoids, and diarylheptanoids. The main bioactive compounds found in this family (cardamom, turmeric, and ginger) are 1,8-cineole, α-terpinyl acetate, β-turmerone, and α-zingiberene. The present review gathers evidence surrounding the effects of dietary intake of extracts of the Zingiberaceae family and their underlying mechanisms of action. These extracts could be an adjuvant treatment for oxidative-stress-related pathologies. However, the bioavailability of these compounds needs to be optimized, and further research is needed to determine appropriate concentrations and their antioxidant effects in the body.

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Section: Antioxidant Activity Of Zingiberaceae Familymentioning

confidence: 99%

Antioxidant Activity in Extracts from Zingiberaceae Family: Cardamom, Turmeric, and Ginger

et al. 2023

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“…It also increases inflammatory mediator production and expression of adhesion molecules. Gingerol which is the main bioactive of ginger disrupts Toll-like receptors (TLR) related signaling pathways and suppresses inflammasomes, and oxidative stress (Alolga et al, 2022).…”

Section: Zingiber Officinalementioning

confidence: 99%

Prominent Medicinal Plants for the Treatment of Neurodegenerative Disorders

Sajid,

Abbas,

Khan

et al. 2023

Complementary and Alternative Medicine: One Health Perspective

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The phrase "neurodegenerative diseases" refers to conditions that cause a major loss of neurons, both structurally and functionally. Neurodegenerative diseases are serious life-threatening in which neural cells in the brain stop working or die. One of the most recently discovered pathogenic processes in the genesis of neurological illnesses is mitochondrial dysfunction. Mitochondria play a significant role in various cellular processes such as the production of ATP, intracellular calcium, and generation of reactive oxygen species and improper function leads to diseases. Oxidative stress and aging are two other prevalent etiologies of neurological diseases. Several side effects have emerged as a result of current treatment methods and the progressive nature of illnesses, prompting patients to switch to other medications. The helpful impact of medicinal plants in these situations has been attributed to their demonstration through several cellular and molecular processes. Traditional plants have a few neuroprotective mechanisms: they reduce inflammatory responses, regulate pro-inflammatory cytokines' functional aspects such as tumor growth, and enhance antioxidant qualities. Plant prevention strategies for these diseases heavily rely on variations in transcription and transduction pathways. Some of the therapeutic herbs for preventing neurological disorders are Panax ginseng, Curcuma longa, Zingiber officinale, Ginkgo biloba, and Utrica diocia, etc., have shown antioxidant as well as anti-inflammatory effects and also show a promising tool for treating neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, multiple sclerosis, and epilepsy. Medicinal plants contain various phytochemical constituents that improve oxidative stress, reduce mitochondrial damage, and protect against brain damage. In short, use of whole plants or parts of medicinal plants from roots to seeds extracted chemicals are used to prevent neurodegenerative illnesses.

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“…Gingerols (23–25%), shogaols (18–25%), and related ketone derivatives are bioactive constituents of ginger ( Grzanna et al, 2005 ). Gingerols are aromatic phenolic structures composed of a series of structural analogs of 1-(3-methoxy-4-hydroxyphenyl) 3-oxo-5-hydroxy-hexane, bearing different lengths of the unbranched alkyl side chain ( Denniff et al, 1980 ; de Menezes de Lima et al, 2018 ; Li et al, 2019 ; Mao et al, 2019 ; Alolga et al, 2022 ). Derivatives of gingerols such as 4-, 6-, 7-, 8-, 10-, and 12-gingerols are differentiated based on their unbranched alkyl side chain length ( Figure 1 ).…”

Section: Overview On Gingerolsmentioning

confidence: 99%

Immunomodulatory and anti-inflammatory therapeutic potential of gingerols and their nanoformulations

et al. 2022

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Ginger (Zingiber officinale Roscoe), a member of the Zingiberaceae family, is one of the most popular spices worldwide, known since ancient times, and used both as a spice and a medicinal plant. The phenolic compounds found in ginger are predominantly gingerols, shogaols, and paradols. Gingerols are the major phenolic compounds found in fresh ginger and contain mainly 6-gingerol as well as 4-, 5-, 8-, 10-, and 12-gingerols. Gingerols possess a wide array of bioactivities, such as antioxidant and anticancer, among others. Regarding the different array of biological activities and published data on the mechanisms underlying its action, the complex interaction between three key events, including inflammation, oxidative stress, and immunity, appears to contribute to a plethora of pharmacological activities of this compound. Among these, the immunomodulatory properties of these compounds, which attract attention due to their effects on the immune system, have been the focus of many studies. Gingerols can alleviate inflammation given their ability to inhibit the activation of protein kinase B (Akt) and nuclear factor kappa B (NF-κB) signaling pathways, causing a decrease in proinflammatory and an increase in anti-inflammatory cytokines. However, given their low bioavailability, it is necessary to develop new and more effective strategies for treatment with gingerols. In order to overcome this problem, recent studies have addressed new drug delivery systems containing gingerols. In this review, the immunomodulatory activities of gingerol and its underlying mechanisms of action combined with the contributions of developed nanodrug delivery systems to this activity will be examined.

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Bioactive Compounds from the Zingiberaceae Family with Known Antioxidant Activities for Possible Therapeutic Uses

Cited by 17 publications

References 146 publications

Antioxidant Activity in Extracts from Zingiberaceae Family: Cardamom, Turmeric, and Ginger

Antioxidant Activity in Extracts from Zingiberaceae Family: Cardamom, Turmeric, and Ginger

Prominent Medicinal Plants for the Treatment of Neurodegenerative Disorders

Immunomodulatory and anti-inflammatory therapeutic potential of gingerols and their nanoformulations

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