Bioactive Compounds from Plant-Based Functional Foods: A Promising Choice for the Prevention and Management of Hyperuricemia

Jiang, Linlin; Gong, Xue; Ji, Minjun; Wang, Congcong; Wang, Jianhua; Li, Min-Hui

doi:10.3390/foods9080973

Cited by 60 publications

(56 citation statements)

References 127 publications

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“…Additionally, we demonstrated that DMLE could decrease serum UA levels in PO-induced hyperuricemic mice by inhibiting hepatic XOD activity. Inhibiting XOD activity in the liver reduces UA production and enhances UA excretion [43,44]. DMLE-70 at all doses did not exhibit potent hypouricemic effects in serum compared with PC, but inhibiting hepatic XOD activity was significantly effective with DMEE-200 compared with the PC (Table 6), although the amount of uric acid excreted in urine was decreased compared with PC.…”

Section: Discussionmentioning

confidence: 98%

Antihyperuricemic Effect of Dendropanax morbifera Leaf Extract in Rodent Models

Lee

Kim

Han

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Dendropanax morbifera is a well-known traditional medicine used in China and Korea to treat intestinal disorders, urosis, diuresis, and chronic glomerulonephritis. Hyperuricemia is a metabolic disorder characterized by a high uric acid level in serum due to an imbalance between uric acid production and excretion and causes gout. Recently, the prevalence of hyperuricemia worldwide has been continuously increasing. Xanthine oxidase (XOD) inhibitors (allopurinol (ALP) and febuxostat) and uricosuric agents (benzbromarone and probenecid) are used to treat hyperuricemia clinically. However, because these drugs are poorly tolerated and cause side effects, such as kidney diseases, hepatotoxicity, gastrointestinal symptoms, and hypersensitivity syndrome, only a limited number of drugs are available. We investigated the antihyperuricemic effects of Dendropanax morbifera leaf ethanol extract (DMLE) and its underlying mechanisms of action through in vitro and in vivo studies. We evaluated uric acid levels in serum and urine, and xanthine oxidase (XOD) inhibition activity in the serum and liver tissue of a hyperuricemic rat model of potassium oxonate (PO)-induced hyperuricemic rats. In vitro study, XOD-inhibitory activity was the lowest among the test substances at the IC50 of ALP. However, the IC50 of DMLE-70 was significantly low compared with that of other DMLEs ( p < 0.05 ). In PO-induced hyperuricemic rats, uric acid (UA) levels in serum and urine were significantly reduced in all DMLE-70 and allopurinol-treated (ALT) groups than in the PC group ( p < 0.05 ). UA levels in urine were lower than those in serum in all DME groups. In PO-induced hyperuricemic rats, DMEE-200 reduced UA concentration in serum and increased UA excretion in the urine. These findings suggest that DMLE exerts antihyperuricemic and uricosuric effects on promoting UA excretion by enhanced secretion and inhibition of UA reabsorption in the kidneys. Thus, DMLE may be a potential treatment for hyperuricemia and gout.

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Section: Discussionmentioning

confidence: 98%

Antihyperuricemic Effect of Dendropanax morbifera Leaf Extract in Rodent Models

Lee

Kim

Han

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Flavonoids are an important group of bioactive secondary metabolites found widely in plants . They are also important natural bioactive ingredients in several plantbased functional foods (Jiang et al, 2020). In recent years, the immune-enhancing effects of flavonoids have attracted considerable attention.…”

Section: Flavonoidsmentioning

confidence: 99%

“…Alkaloids are nitrogenous compounds other than proteins, peptides, amino acids, and vitamin B that mainly exist in the plant kingdom (Song and Jiang, 2017). Owing to their complex structures and remarkable biological activities, their roles in immune enhancement should not be ignored (Jiang et al, 2020). Indeed, it is known that alkaloids play an immuneenhancing role by regulating the proliferation of thymic and splenic lymphocytes and the secretion of cytokine (Zhou et al, 2020).…”

Section: Alkaloidsmentioning

confidence: 99%

“…In recent years, they have been extensively consumed because of their high bioactive components and health benefits (Mohamad et al, 2020). Notably, growing evidence from pre-clinical research has shown that plant-based functional foods can reduce the risk of developing various disorders, such as diabetes, cancer, cardiovascular disease, hyperlipidemia, and hyperuricemia (Andrea et al, 2017;Gong et al, 2019;Mehmood et al, 2019;Gong et al, 2020;Jiang et al, 2020). Owing to a growing awareness of the capabilities of plant-based functional foods to combat diseases, studies on immune boosters based on plantbased functional foods have received substantial attention, and an increased number of individuals continue to choose plant-based functional foods to improve immune system functions (Davoodvandi et al, 2019;Shafabakhsh et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Potential Application of Plant-Based Functional Foods in the Development of Immune Boosters

Jiang

Zhang

et al. 2021

Front. Pharmacol.

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Immune dysfunction, which is responsible for the development of human diseases including cancer, is caused by a variety of factors. Therefore, regulation of the factors influencing the immune response is a potentially effective strategy to counter diseases. Presently, several immune adjuvants are used in clinical practice to enhance the immune response and host defense ability; however, synthetic drugs can exert negative side effects. Thus, the search for natural products of plant origin as new leads for the development of potent and safe immune boosters is gaining considerable research interest. Plant-based functional foods have been shown to exert several immunomodulatory effects in humans; therefore, the application of new agents to enhance immunological and specific host defenses is a promising approach. In this comprehensive review, we have provided an up-to-date report on the use as well as the known and potential mechanisms of bioactive compounds obtained from plant-based functional foods as natural immune boosters. Plant-based bioactive compounds promote immunity through multiple mechanisms, including influencing the immune organs, cellular immunity, humoral immunity, nonspecific immunity, and immune-related signal transduction pathways. Enhancement of the immune response in a natural manner represents an excellent prospect for disease prevention and treatment and is worthy of further research and development using approaches of modern science and technology.

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“…This special issue also includes three literature review papers that emphasize the added value that the secondary metabolites, and the species they are isolated from, have in the development of new medicines to prevent/treat prevalent diseases. Jiang et al [13] present a comprehensive literature revision of the secondary metabolites present in plant-based functional foods that exhibit the ability to lower the level of uric acid, using in vitro and in vivo models. A detailed discussion concerning the targets and the action mechanism associated to their hypouricemic effect is presented.…”

mentioning

confidence: 99%