Bioactive Compounds from Garcinia Fruits of High Economic Value for Food and Health

Murthy, Hosakatte Niranjana; Dandin, Vijayalaxmi S.; Dalawai, Dayanand; Park, Soyoung; Paek, Kee-Yoeup

doi:10.1007/978-3-319-78030-6_65

Cited by 17 publications

(12 citation statements)

References 113 publications

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“…where G (template-monomer complex) = non-covalent binding energy of template-monomer complex, G (template) = binding energy of template, G (monomer) = binding energy of monomer, and n = monomer ratio (1,2,3,4,5,6).…”

Section: Computational Design Of Mipmentioning

confidence: 99%

“…[1][2][3][4] The xanthone compounds include mangostenol, mangostinon A, mangostenon B, trapezifolixanthone, tovophyllin B, α-mangostin, β-mangostin, garcinone B, mangostanol, flavonoid epicatechin, and gartanin. 5 The α-mangostin compound is the most abundant content in mangosteen rind. [5][6][7] α-mangostin in mouse plasma is biphasic; meaning that it experiences fast distribution and slow elimination.…”

Section: Introductionmentioning

confidence: 99%

“…5 The α-mangostin compound is the most abundant content in mangosteen rind. [5][6][7] α-mangostin in mouse plasma is biphasic; meaning that it experiences fast distribution and slow elimination. 8 When given orally, AM has lower plasma concentrations than intravenously.…”

Section: Introductionmentioning

confidence: 99%

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Design, synthesis, and characterization of molecularly imprinted solid phase extraction for alpha Mangostin analysis in blood sample

Rachmawati,

Hasanah,

Muttaqin

et al. 2024

Polymers for Advanced Techs

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Low levels of α‐mangostin (AM) in biological fluids require adequate sample preparation to be analyzed. Molecularly imprinted polymers can serve as sorbents in solid phase extraction, enabling concentration and extraction of α‐mangostin from complex matrices, such as biological fluids. To date, there are no molecular imprinted polymers for the analysis of α‐mangostin in biological fluids. In this study, AM molecular imprinted polymer (MIP) was designed using molecular modeling, molecular dynamic simulations, and prepared by bulk polymerization and suspension polymerization methods. The geometry optimization results showed that acrylamide (AAM) monomer forms the most stable complex with AM at the pre‐polymerization with the most negative Gibbs free energy (ΔG) of −6.91818 Kcal/mol. Radial distribution function (RDF) in molecular dynamics simulation of AM:AAM:ethylene glycol dimethacrylate (EGDMA) with mol ratio 1:4:20 shows the complex with the best composition through the formation of four stable hydrogen bonds. Based on the experimental results, molecularly imprinted polymers in suspension exhibit better characteristics, selectivity, and adsorption capacity than in bulk. The suspension polymerization method showed a high recovery (85.88% ± 2.5), which was higher than C18 SPE cartridge (24.19% ± 1.47). Hence, it can be concluded that the MIPs from MD simulations were accessible and could be used in practice, such as in the separation and detection of AM in blood serum.

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Section: Computational Design Of Mipmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Design, synthesis, and characterization of molecularly imprinted solid phase extraction for alpha Mangostin analysis in blood sample

Rachmawati,

Hasanah,

Muttaqin

et al. 2024

Polymers for Advanced Techs

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“…α-Mangostin is the most abundant xanthone in the mangosteen pericarp, followed by γmangostin. 42 It has been reported that 1 kg of mangosteen can generate 0.6 kg of mangosteen pericarps, which provide a sufficient source of mangostins. 43 In this study, we analyzed the structure−activity relationships of α-mangostin and γ-mangostin.…”

Section: Structure−activity Relationships Of α-Mangostinmentioning

confidence: 99%

Discovery of Multitarget Inhibitors against Insect Chitinolytic Enzymes via Machine Learning-Based Virtual Screening

Ding

Chen

Liu

et al. 2023

J. Agric. Food Chem.

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Multitarget inhibitors of insect chitinolytic enzymes are promising sources of green insecticides. Machine learning (ML) is an emerging virtual screening method that can accelerate drug discovery and reduce costs. Taking advantage of the data from our previous high-throughput screening work, we established a strategy integrating ML and molecular docking to screen a large natural product library (17 600 compounds) to identify novel multitarget inhibitors of four chitinolytic enzymes from the insect Ostrinia furnacalis (Of ChtI, Of ChtII, Of Chi-h, and Of Hex1). 3,5-Di-O-caffeoylquinic acid and γ-mangostin were identified as inhibitors of all of these enzymes with K i values at the μM level. Moreover, they showed significant biological activities against lepidopteran pests. Transcriptomic analysis of compound-treated insects suggested the physiological relationship between these compounds and chitinolytic enzymes. This study highlights the potential of ML for insecticide discovery and provides novel and lowcost scaffolds of multitarget inhibitors against insect chitinolytic enzymes as potential pesticide leads.

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“…Desr.] and Kokum (Botanical name: Garcinia indica Choisy) are the commercial yielding fruit trees of Garcinia cultivated in Australia, Cuba, Dominica, Ecuador, Gabon, Ghana, Guatemala, Honduras, India, Jamaica, Liberia, Myanmar, Nepal, Philippines, Puerto Rico, Singapore, Sri Lanka, Thailand, Trinidad and Tobago, United States of America, Vietnam, and Zanzibar (Murthy et al, 2019) [4] . There are more than 200 species in the genus about 30 are found in India.…”

Section: Introductionmentioning

confidence: 99%

Garcinia a medicinally potential genus in Western Ghats

Khapare¹,

Kadam²,

Shirke³

2020

J Pharmacogn Phytochem

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The Western Ghats, is one of the hotspots of biodiversity, having plentiful economic as well as medicinal value. Garcinia is an important genus distributed in the Western Ghats having vast nutraceuticals potential. Its economic, medicinal and ecological potential make it ideally suited to the restoration of natural forests of Western Ghats. The different species comes under genus Garcinia abundant with bioactive compounds that possess antioxidant, anti-inflammatory, anticancer, antimicrobial, antiallergy, antiulcer, antiparasitic, and antihelminthic activities. The genus is represented by more than 200 species, among which 30 species are found in India. Garcinia mangostana (mangosteen or purple mangosteen); G. cambogia (Malabar tamarind) and G. indica (kokum) are the major commercially important species cultivated in tropical countries. The habitat, bioactive compounds especially phenolic acids and organic acids, therapeutic values and medicinal values of these species are reviewed so as to exploit its economic and medicinal potential.

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Bioactive Compounds from Garcinia Fruits of High Economic Value for Food and Health

Cited by 17 publications

References 113 publications

Design, synthesis, and characterization of molecularly imprinted solid phase extraction for alpha Mangostin analysis in blood sample

Design, synthesis, and characterization of molecularly imprinted solid phase extraction for alpha Mangostin analysis in blood sample

Discovery of Multitarget Inhibitors against Insect Chitinolytic Enzymes via Machine Learning-Based Virtual Screening

Garcinia a medicinally potential genus in Western Ghats

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