Bioactive compounds for neuropathic pain: An update on preclinical studies and future perspectives

Flavonoids bridging the gut and the brain: Intestinal metabolic fate, and direct or indirect effects of natural supporters against neuroinflammation and neurodegeneration

“…The first report that consumption of soy-containing diet protects from the development of partial sciatic nerve ligation-induced neuropathic pain dates back to 2001 [216]. From then on, the beneficial effects of isoflavones in preclinical models of neuropathic pain have been confirmed by several authors, as reviewed by Shen and colleagues [217].…”

Gingerol-Enriched Ginger Supplementation Mitigates Neuropathic Pain via Mitigating Intestinal Permeability and Neuroinflammation: Gut-Brain Connection

“…Mitigating the neuroinflammation offers potential therapeutic targets in NP management. Dietary bioactive compounds have gained attention for NP and NPrelated neuroinflammation due to their anti-inflammatory and anti-oxidant properties (Shen et al, 2022a). Therefore, the development and assessment of bioactive compounds for NP management could provide a new, safe, and effective analgesic alternative that is much needed.…”

“…Ginger and its bioactive components have been shown to penetrate the blood-brain barrier via passive diffusion, providing the basis for positive effects of ginger in the CNS (Simon et al, 2020). Ginger's anti-nociceptive capabilities in a number of NP animal studies have been reviewed recently (Shen et al, 2022a). In brief, ginger consumption, in the forms of ginger extract, ginger essential oil, gingerols, and shogaols, has beneficial effects on NP-related parameters including mechanical allodynia and hyperalgesia, thermal and cold hyperalgesia, and anxiety-associated behaviors.…”

“…In brief, ginger consumption, in the forms of ginger extract, ginger essential oil, gingerols, and shogaols, has beneficial effects on NP-related parameters including mechanical allodynia and hyperalgesia, thermal and cold hyperalgesia, and anxiety-associated behaviors. Our team proposed that ginger's underlying mechanisms include the suppression of glial cell and neutrophil activation, inhibition of expression/production of pro-inflammatory cytokines/chemokines, and reduction of circulating cell-free mitochondrial DNA levels (Shen et al, 2022a). However, no study has investigated how GEG would impact leaky gut and neuroinflammation via the gut-brain connection in NP status.…”

Editorial: Application of plant secondary metabolites to pain neuromodulation, volume II

“…Consuming of various forms of ginger ( Zingiber officinale Roscoe) such as ginger extract, ginger essential oils, etc have tremendous antineuropathic effects including thermal and cold hyperalgesia ( Shen et al, 2022a ; Shen et al, 2022b). Shen et al in their original research article entitled “Gingerol-Enriched Ginger Supplementation Mitigates Neuropathic Pain via Mitigating Intestinal Permeability and Neuroinflammation: Gut-Brain Connection” have presented a noteworthy role of gut-brain axis in mitigation of the neuropathic pain that were validated by the in vivo experiments on male rats.…”