Bioactive compounds extraction of Croton lechleri barks from Amazon forest using chemometrics tools

Diedrich, Camila; Silva, Letícia Dangui da; Sari, Rafael; Borges, Giulia Caroline de Cristo; Muniz, Henrique; Lima, Vanderlei Aparecido de; Oldoni, Tatiane Luiza Cadorin; Carpes, Solange Teresinha

doi:10.1016/j.jksus.2021.101416

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…Croton lechleri (Sangre de Drago), of the family Euphorbiaceae, a sap rich in phenolic compounds with the ability to reduce ROS formation, LDL oxidations, and albumin glycation, thereby reducing the risk of vascular diseases [ 47 , 48 ]. Uncaria tomentosa (Uña de Gato or Cat’s claw) is a vine of the Rubiaceae family with antimutagenic and neuroprotective properties.…”

Section: Resultsmentioning

confidence: 99%

In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics against Alzheimer’s Disease

et al. 2022

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Background: Despite research on the molecular bases of Alzheimer’s disease (AD), effective therapies against its progression are still needed. Recent studies have shown direct links between AD progression and neurovascular dysfunction, highlighting it as a potential target for new therapeutics development. In this work, we screened and evaluated the inhibitory effect of natural compounds from native Peruvian plants against tau protein, amyloid beta, and angiotensin II type 1 receptor (AT1R) pathologic AD markers. Methods: We applied in silico analysis, such as virtual screening, molecular docking, molecular dynamics simulation (MD), and MM/GBSA estimation, to identify metabolites from Peruvian plants with inhibitory properties, and compared them to nicotinamide, telmisartan, and grapeseed extract drugs in clinical trials. Results: Our results demonstrated the increased bioactivity of three plants’ metabolites against tau protein, amyloid beta, and AT1R. The MD simulations indicated the stability of the AT1R:floribundic acid, amyloid beta:rutin, and tau:brassicasterol systems. A polypharmaceutical potential was observed for rutin due to its high affinity to AT1R, amyloid beta, and tau. The metabolite floribundic acid showed bioactivity against the AT1R and tau, and the metabolite brassicasterol showed bioactivity against the amyloid beta and tau. Conclusions: This study has identified molecules from native Peruvian plants that have the potential to bind three pathologic markers of AD.

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Section: Resultsmentioning

confidence: 99%

In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics against Alzheimer’s Disease

et al. 2022

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“…Estudiaron las otras partes de esta planta Crotón lechleri, para así poder validar sus usos tradicionales y poder describir su composición química, utilizando para dicho estudio las hojas corteza, los tallos (madera), las semillas y flores manifiestan que posee actividades biológicas, que benefician la salud de las personas. Mientras que (20), concuerdan que las hojas, la corteza del árbol, y su savia son de interés farmacéutico por Además, el extracto de Crotón lechleri posee actividad antimicrobiana, inhibe el crecimiento de helicobacter pylori y posee un efecto bactericida sobre el mismo, también sobre bacterias aisladas de ulceras cutáneas sobreinfectadas (14,3,5). (6,7,16).…”

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Efecto antibacteriano de la sangre de drago en cultivos in vitro en cepas bacterianas ATCC

Masabanda

Hidalgo

2023

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Objetivo. El objetivo de la investigación fue evaluar el efecto antibacteriano de la sangre de drago (Crotón lechleri) en cultivos in vitro de cepas bacterianas ATCC; Staphylococcus aureus ATCC 25923 y Escherichia coli ATCC 25922, a diferentes concentraciones 1%, 2%, 4%, 6%, 8%, 16%, 80%, 90% y 100%. Materiales y métodos. Se realizó un total 54 cultivos, de los cuales 27 cultivos corresponden al análisis de extracto Sangre de drago (Crotón lechleri) en distintas concentraciones frente a Staphylococcus aureus ATCC 25923 y 27 cultivos al análisis del extracto Sangre de drago (Crotón lechleri) frente a la bacteria Escherichia coli ATCC 25922, donde se aplicó 3 repeticiones para cada tratamiento. Resultados. En los resultados no se observó ningún halo de inhibición de los discos de sensibilidad preparados en diferentes concentraciones por lo que se consideran las cepas bacterianas ATCC; Staphylococcus aureus 25923 y Escherichia coli 25922, no presentan sensibilidad a la sangre de drago (Crotón lechleri). Conclusiones. De los resultados obtenidos podemos concluir que la sangre de drago (Crotón lechleri) no presenta actividad antibacteriana para las cepas de cepas bacterianas ATCC; Staphylococcus aureus 25923 y Escherichia coli 25922.

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A simple, alternative and efficient sealing system to improve natural ventilation in culture vessels and the morphophysiological and anatomical quality of Croton lechleri (Muell. Arg.) grown in vitro

et al. 2022

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Bioactive compounds extraction of Croton lechleri barks from Amazon forest using chemometrics tools

Cited by 6 publications

References 14 publications

In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics against Alzheimer’s Disease

In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics against Alzheimer’s Disease

Efecto antibacteriano de la sangre de drago en cultivos in vitro en cepas bacterianas ATCC

A simple, alternative and efficient sealing system to improve natural ventilation in culture vessels and the morphophysiological and anatomical quality of Croton lechleri (Muell. Arg.) grown in vitro

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