Bioactive Compounds and Their Effect on Blood Pressure—A Review

Malinowski, Bartosz; Leighton, Raul Ignacio Fajardo; Hill, Christopher G.; Szandorowski, Paweł; Wiciński, Michał

doi:10.3390/nu12061659

Cited by 7 publications

(3 citation statements)

References 95 publications

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“…Another study by reviewing the literature illustrated a good evidence of the BP-lowering effect of bioactive compounds such as lycopene, docosahexaenoic acid, and dietary fiber which are high in DASH dietary pattern. 47 Indeed, a systematic review and meta-analysis in 2020 indicates that DASH diet could significantly increase glutathione and decrease malondialdehyde levels, with a trend to improve total antioxidant capacity (TAC), nitric oxide, and f2-isoprostanes by the adherence to the DASH diet. 48 …”

Section: Discussionmentioning

confidence: 99%

The effect of DASH diet on atherogenic indices, pro-oxidant-antioxidant balance, and liver steatosis in obese adults with non-alcoholic fatty liver disease: A double-blind controlled randomized clinical trial

Badali

Arefhosseini

Rooholahzadegan

et al. 2023

Health Promot Perspect

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Background: The present clinical trial aimed to examine whether adherence to Dietary Approaches to Stop Hypertension (DASH) diet could improve lipid profile, the Pro-oxidant-antioxidant balance (PAB) as well as liver function in obese adults with non-alcoholic fatty liver disease (NAFLD). Methods: Sixty two patients with NAFLD were equally allocated into either DASH or low-calorie diet (LCD) group for 8 weeks. The primary and secondary outcomes were determined before and after the trial. Results: Forty patients completed the trial. Significant within group differences were found in dietary saturated fat, selenium, vitamins A and E as well as body weight and body mass index (BMI) and waist circumference (WC) after the intervention (P<0.05). DASH diet showed greater significant change in systolic and diastolic blood pressure without significant differences between the groups after 8 weeks. Apart from serum high-density lipoprotein cholesterol (HDL-C) and triglyceride/HDL-C, greater reductions were found not only in serum lipids and atherogenic indices (P<0.05) but also in serum aspartate aminotransferase (AST), AST to platelet ratio index (APRI) and lipid accumulation product (LAP) in DASH group in comparison to control group (P=0.008, P=0.019 and P=0.003, respectively). Nevertheless, there was not any difference in PAB level between the groups. Furthermore, adherence to DASH diet was more effective in alleviating liver steatosis compared with usual LCD (P=0.012). Conclusion: Adherence to DASH diet appears to be more effective in improving obesity, atherogenic and liver steatosis biomarkers but not oxidative stress (OS) than usual LCD.

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Section: Discussionmentioning

confidence: 99%

The effect of DASH diet on atherogenic indices, pro-oxidant-antioxidant balance, and liver steatosis in obese adults with non-alcoholic fatty liver disease: A double-blind controlled randomized clinical trial

Badali

Arefhosseini

Rooholahzadegan

et al. 2023

Health Promot Perspect

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“…Non-pharmacological therapies, including lifestyle improvement and dietary modification, and pharmacological treatments, including antihypertensive, lipid-lowering and antidiabetic medications are the cornerstone of cardiovascular disease prevention. While antioxidants such as carotenoids have not been directly used in the treatment of hypertension, dietary modifications (including the Approaches to Stop Hypertension (DASH) and Mediterranean diets) that recommend regular consumption of carotenoid-rich fruits and vegetables clearly play a role in lowering BP and have been officially endorsed by health organizations (22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Inverse association of serum carotenoid levels with prevalence of hypertension in the general adult population

et al. 2022

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Carotenoid levels are inversely associated with blood pressure (BP). This study focused on the effects of individual and combined serum carotenoids on BP and hypertension, which have not been established to date. Data from National Health and Nutrition Examination Survey (NHANES) 2001–2006 were analyzed in this cross-sectional study. Multivariate logistic, linear, and weighted quantile sum (WQS) regression analyses were applied to explore the associations of six serum carotenoids (α-carotene, β-cryptoxanthin, lutein/zeaxanthin, trans-lycopene, trans-β-carotene, and cis-β-carotene), individually and in combination, with BP/hypertension. The linearity of correlations was further assessed using restricted cubic spline (RCS) regression. A total of 11,336 adults were included for analysis. Data from multivariate models showed that all six carotenoids were independently and negatively associated with both systolic blood pressure (SBP) and diastolic blood pressure (DBP; all p < 0.05). Compared to the first quartile, the fourth quartile of α-carotene (odds ratio [OR] = 0.64 [0.52–0.77]), β-cryptoxanthin (OR = 0.74 [0.60–0.90]), trans-β-carotene (OR = 0.50 [0.40–0.61]), and cis-β-carotene (OR = 0.47 [0.35–0.64]) were significantly and inversely related to hypertension (all p < 0.05). Moreover, WQS analysis revealed that the combination of all six serum carotenoids was negatively associated with BP and hypertension (all P<0.001), among which trans-β-carotene was the most significant contributor to the protective effect against hypertension (weight, 59.50%). Dose-response analyses demonstrated a linear inverse association of all carotenoids with hypertension (p for non-linearity > 0.05). Our collective findings indicate that higher levels of all six mixed serum carotenoids are correlated with decreased prevalence of hypertension, among which β-carotene exerts the most significant effect, which may provide a basis and direction for further studies.

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“…Regarding arterial remodeling and atheromatosis, it was highlighted that there is scarce evidence, which does not allow solid conclusions. Lastly, the Special Issue also included another review by Malinowski et al that examined the available evidence on the effect of a range of dietary compounds on blood pressure levels [ 9 ]. This review reported that there is good evidence suggesting the blood pressure-lowering effect of lycopene, docosahexaenoic acid (i.e., omega-3 fatty acid), epigallocatechin-3-gallate (i.e., a type of catechin found in tea) and dietary fibre, although further studies are required to strengthen these findings.…”

mentioning

confidence: 99%