Bioactive compounds and mechanism of Xianglian pill in the treatment of gastric cancer: Network pharmacology analysis and experimental validation

Yu, Lei; Sun, Luyao; Yu, Qian; Xiong, Fang; Wang, Daibo; Peng, Lin; Peng, Fu; Xie, Xiaofang; Peng, Cheng

doi:10.1016/j.jep.2023.116573

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…Finger Citron inhibits tumor cell proliferation and invasion and induces apoptosis by downregulating Cyc-D1, MMP and bcl-2 through siRNA-mediated Zeb1 silencing replication to promote Zeb1 overexpression 23 . Ligustrazine in Szechuan Lovage Rhizome may improve microcirculatory disorders and reduce damage to the gastric mucosa by increasing gastric blood flow and reducing inflammatory mediators 24 . Total saponins of panax can reduce the expression of Vemintin, SNAIL, MMP2 and MMP9 and increase the expression of P21, Caspase-3 and Bax in gastric cancer cell lines, thus promoting apoptosis of tumor cells and hindering their proliferation, migration and invasion 25 .…”

Section: Discussionmentioning

confidence: 99%

Exploring the HIF-1α signalling pathway and the mechanism of YiQiHuoXue decoction against Precancerous Lesions of Gastric Cancer based on Network Pharmacology and Molecular Docking

Qian,

Xie,

Zhao

et al. 2024

J. Cancer

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Precancerous Lesions of Gastric Cancer (PLGC) are an essential step in the advancement of Gastric cancer (GC). Early intervention represents the most effective strategy to impede the development of PLGC. However, additional research is necessary to comprehend the molecular mechanism of PLGC. YQHXD is originated from Si Wu Decoction, has been utilized as an empirical formula for the treatment of PLGC for several years. In this study, we employed network pharmacology, molecular docking, and experimental validation to examine the inhibitory and ameliorative properties of YQHXD on PLGC. Multiple databases were utilized to gather genetic information on drugs in PLGC and YQHXD, in order to obtain cross-targets. We discovered 142 common targets between YQHXD and PLGC. GO and KEGG enrichment analyses indicate that YQHXD treatment of PLGC might be linked with cellular response to oxygen levels and the HIF-1α signaling pathway. Finally, we performed in vitro experiments, of which the results reveal that YQHXD mitigates gastric mucosal atrophy, intestinalization, and heterogeneous hyperplasia, and reduces the expression of inflammatory factors in rats. Therefore, we considered that YQHXD has the potential to delay the PLGC process by inhibiting the HIF-1α signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Exploring the HIF-1α signalling pathway and the mechanism of YiQiHuoXue decoction against Precancerous Lesions of Gastric Cancer based on Network Pharmacology and Molecular Docking

Qian,

Xie,

Zhao

et al. 2024

J. Cancer

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“…Additionally, XLP can improve antibiotic-associated diarrhea (AAD) by reducing mucosal damage and increasing the expression of claudin-1 and occludin ( Yang et al, 2021 ). A study has indicated that dehydrocostus lactone and berberrubine are the two main active components in XLP with anti-GC effects ( Yu et al, 2023 ). Wan et al (2008) investigated the berberine content in different proportions (1:1, 2:1, 3:1, 4:1, 5:1, 6:1, 7:1, 8:1, and 9:1) of CR and AR in XLP.…”

Section: Main Herb Pairs Containing Coptidis Rhizomamentioning

confidence: 99%

Several major herb pairs containing Coptidis rhizoma: a review of key traditional uses, constituents and compatibility effects

Li,

Xu,

Chen

et al. 2024

Front. Pharmacol.

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Herb compatibility is the soul of traditional Chinese Medicine prescriptions. Coptidis rhizoma (CR) (Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao, or Coptis teeta Wall.; family Ranunculaceae), is a well-known herb. The bitter and cold nature of CR can irritate the spleen and stomach, and certain ingredients in CR may trigger allergic reactions. Herb combinations can help alleviate the side effects caused by CR. Through data analysis and literature research, there are many herbs combined with CR have a high frequency, but only a few are currently used as formulae in clinical practice. The results showed that these six herb pairs are usually widely studied or used as prescriptions in the clinic. This paper describes the six herb pairs from the key traditional uses, changes in bioactive constituents, and compatibility effects, especially with Euodiae fructus (family Rutaceae), Scutellariae radix (family Lamiaceae), Magnoliae Officinalis cortex (family Magnoliaceae), Glycyrrhizae radix et rhizoma (family Fabaceae), Ginseng radix et rhizoma (family Araliaceae), and Aucklandiae radix (family Asteraceae), and found that herbs are more effective when used in combination. Therefore, it is feasible to establish some methods to study herb pairs comprehensively from different perspectives. This paper aims to provide the latest and most comprehensive information on the six herb pairs and summarize the pattern of CR compatibility effects. It aims to attract more attention, and further experimental studies will be conducted to investigate and evaluate the effects of herb pairs containing CR. These data can also provide valuable references for researchers and also provide more possibilities for future applications in clinical practice and new drug development.

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“…Additionally, XLP can improve antibiotic-associated diarrhea (AAD) by reducing mucosal damage and increasing the expression of claudin-1 and occludin (Yang et al, 2021). A study has indicated that dehydrocostus lactone and berberrubine are the two main active components in XLP with anti-GC effects (Yu et al, 2023). Wan et al (2008) investigated the berberine content in different proportions (1:1, 2:1, 3:1, 4:1, 5:1, 6:1, 7:1, 8:1, and 9:1) of CR and AR in XLP.…”

Section: Coptidis Rhizoma and Aucklandiae Radixmentioning

confidence: 99%

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Bioactive compounds and mechanism of Xianglian pill in the treatment of gastric cancer: Network pharmacology analysis and experimental validation

Cited by 5 publications

References 30 publications

Exploring the HIF-1α signalling pathway and the mechanism of YiQiHuoXue decoction against Precancerous Lesions of Gastric Cancer based on Network Pharmacology and Molecular Docking

Exploring the HIF-1α signalling pathway and the mechanism of YiQiHuoXue decoction against Precancerous Lesions of Gastric Cancer based on Network Pharmacology and Molecular Docking

Several major herb pairs containing Coptidis rhizoma: a review of key traditional uses, constituents and compatibility effects

Table1.docx

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