Bioactive compounds and hepatoprotective effect of Hancornia speciosa gomes fruit juice on acetaminophen-induced hepatotoxicity in vivo

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

“…The animals were treated orally with the extract at a dose of 400 mg/kg for 21 days after streptozotocin administration, leading to a decrease in hepatic transaminases and in liver weight, with no signs of toxicity in the treated animals. Recently, Santos et al [39] . used lyophilized H. speciosa fruit juice to evaluate the hepatoprotective properties in rats with liver damage induced by acetaminophen.…”

“…Female Wistar rats Acetaminophen (900 mg/kg, p.o.) [39] Himatanthus articulatus (Vahl) Woodson Barks, latex/decoction Sore liver Female Swiss mice Bromobenzene (9 mmol/kg, p.o.) [46] Essential oil-loaded nanocapsules (1.5 mL/kg, p.o.…”

“…The animals were treated orally with the extract at a dose of 400 mg/kg for 21 days after streptozotocin administration, leading to a decrease in hepatic transaminases and in liver weight, with no signs of toxicity in the treated animals. Recently, Santos et al [39] used lyophilized H. speciosa fruit juice to evaluate the hepatoprotective properties in rats with liver damage induced by acetaminophen. Oral pre-treatment with the extract (200 mg/kg) for 10 days was effective in reducing the liver function markers ALT, AST and GGT and the production of MDA, acting as an inhibitor of lipid peroxidation, attributed to the presence of the main phenolics chlorogenic acid and rutin (6).…”

Medicinal herbs and their metabolites with biological potential to protect and combat liver toxicity and its disorders: A review

“… [ 131 ] Hancornia specicosa ( Apocyana-ceae) Freeze dried extract of Fruit juice Rats Paracetamol 200 mg/kg AST↓, ALT↓, GGT↓ Chlorogenic acid ( 30 ), rutin Used in tuberculosis, gastric ulcer, diarrhea and inflammatory disorders. [ 132 ] Hedyotis corymbosa ( Rubiaceae ) Methanolic extract of Whole plants Albino (Wistar) rats Paracetamol 100 and 200 mg/kg SGPT↓, SGOT↓,and serum bilirubin↓ Used in viral infections, cancer, syndromes involving “toxic heat”, acne, boils, skin ailments, appendicitis, hepatitis, eye diseases and bleeding. [ 133 ] Hibiscus sabdariffa ( Malvaceae ) Aqueous extract of Flowers Male Wistar rats Azathioprine 10 ml (10 gm/100 ml) ALT↓,AST↓ Hypertension [ 134 ] Hoslundia opposite (Lamiaceae ) Methanolic and ethyl acetate extract of Stem Mice Carbon tetrachloride 400 mg/kg bw AST↓, ALT↓, Bilirubin↓ Antipyretic, diuretic, and antimalarial.…”

Yellow Himalayan Raspberry (Rubus ellipticus Sm.): Ethnomedicinal, Nutraceutical, and Pharmacological Aspects

“…These extracts were able to normalize increased blood urea nitrogen, serum uric acid, creatinine, and serum urea levels induced by cisplatin and gentamicin [ 128 ]. Such a potent nephroprotective activity might be due to the presence of certain phytochemicals like phenols, tannins, flavonoids, and triterpenoids, which act as an antioxidant, reducing the risk of renal dysfunction [ 129 , 130 , 131 ]. Likewise, the ethanolic extract of R. ellipticus was found to be an effective nephroprotective agent compared to its petroleum ether and aqueous extract.…”