Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe)

Abstract

Ginger (Zingiber officinale Roscoe) is a common and widely used spice. It is rich in various chemical constituents, including phenolic compounds, terpenes, polysaccharides, lipids, organic acids, and raw fibers. The health benefits of ginger are mainly attributed to its phenolic compounds, such as gingerols and shogaols. Accumulated investigations have demonstrated that ginger possesses multiple biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, neuroprotective, cardiovascular protective, respiratory protective, antiobesity, antidiabetic, antinausea, and antiemetic activities. In this review, we summarize current knowledge about the bioactive compounds and bioactivities of ginger, and the mechanisms of action are also discussed. We hope that this updated review paper will attract more attention to ginger and its further applications, including its potential to be developed into functional foods or nutraceuticals for the prevention and management of chronic diseases.

Role of Garlic and Ginger in Anti-oxidative and Anti-inflammatory Effects in Aging

“…The main phenolic compounds are gingerols, 6-shogaols, and 6paradols that have been reported to have various biological activities. The major polyphenols identified in the fresh ginger are gingerols (6gingerol, 8-gingerol, and 10-gingerol) [28,29]. In addition, quercetin, zingerone, gingerenone-A, and 6-dehydrogingerdione were also other phenolic compounds reported in ginger.…”

“…Ginger root is the most commonly used for home remedies like headache, nausea, common cold and emesis. It possesses various life activities, such as antioxidant, anti-microbial, antiinflammatory, anti-cancer activities [28]. Adding evidence to that ginger has also been reported to inhibit and regulate several diseases, such as neurodegenerative diseases, heart diseases and metabolic disorders like diabetes mellitus and obesity, and respiratory disorders [28].…”

“…It possesses various life activities, such as antioxidant, anti-microbial, antiinflammatory, anti-cancer activities [28]. Adding evidence to that ginger has also been reported to inhibit and regulate several diseases, such as neurodegenerative diseases, heart diseases and metabolic disorders like diabetes mellitus and obesity, and respiratory disorders [28]. Most abundant compounds in ginger are phenolic and terpene compounds [29].…”

Studi In Silico: Prediksi Potensi 6-shogaol dalam Zingiber officinale sebagai Inhibitor JNK

“…Penggunaan rimpang jahe sebagai obat terus meningkat karena dianggap sangat aman dikonsumsi, rendah toksisitas, serta memiliki efek farmakologis. Jahe mengandung senyawa polifenol seperti 6-gingerol, 6-shogaol dan derivatnya yang bersifat antioksidan (Mao et al, 2019;Teng et al, 2019). Senyawa shogaol merupakan komponen keton fenolik, memiliki efek farmakologi kardiovaskular, gastro-intestinal (antiemetik, antinausea, antiulser), antiokidan, anti-inflamatori, antimikroba (analgesik, sedatif, antipiretik, antibakteri) (Teng et al, 2019).…”

Effects of Xiao-Ban-Xia-Tang Formula on Cisplatin and 1-phenylbiguanide Hydrochloride Induced Emesis and Gut Microbiota in the Pica Model of Rats

“…), and is usually used for the treatment of vomiting [6]. Ginger and its extracts have been found to have many biological and pharmaceutical activities, such as anti-in ammatory, anticancer, antiobesity, antinausea and antiemetic activities [7]. Our previous study has shown that [6]-Gingerol, a major component of ginger, could signi cantly ameliorate the cisplatin-induced pica in rats [8].…”