Bioactive composition, antifungal, antioxidant, and anticancer potential of agarwood essential oil from decaying logs (Gyrinops spp.) of Papua Island (Indonesia)

Hidayat, Asep; Turjaman, Maman; Qamyari, Ruqoyah; Imanuddin, Rinaldi; Tohir, Dudi; Rahmanto, Raden Gunawan Hadi; Susilowati, Arida

doi:10.7324/japs.2021.1101010

Cited by 7 publications

(5 citation statements)

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“…Agarwood and its products, either as oil, smoke, or powder admixtures, are well known for their bioactivity in controlling various fungal pathogens and their unique medicinal properties globally [ 75 ]. Several chemical compounds have been reported to be identified from agarwood such as chromone derivates, terpenoids, flavonoids, benzophenones, lignans, benzenoid derivates, phenolic compounds, triterpenes, steroids, and other chemical compounds [ 58 , 76 ].…”

Section: Bioactive Compounds Obtained From Agarwood Their Pharmaceuti...mentioning

confidence: 99%

Agarwood—The Fragrant Molecules of a Wounded Tree

et al. 2022

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Agarwood, popularly known as oudh or gaharu, is a fragrant resinous wood of high commercial value, traded worldwide and primarily used for its distinctive fragrance in incense, perfumes, and medicine. This fragrant wood is created when Aquilaria trees are wounded and infected by fungi, producing resin as a defense mechanism. The depletion of natural agarwood caused by overharvesting amidst increasing demand has caused this fragrant defensive resin of endangered Aquilaria to become a rare and valuable commodity. Given that instances of natural infection are quite low, artificial induction, including biological inoculation, is being conducted to induce agarwood formation. A long-term investigation could unravel insights contributing toward Aquilaria being sustainably cultivated. This review will look at the different methods of induction, including physical, chemical, and biological, and compare the production, yield, and quality of such treatments with naturally formed agarwood. Pharmaceutical properties and medicinal benefits of fragrance-associated compounds such as chromones and terpenoids are also discussed.

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Section: Bioactive Compounds Obtained From Agarwood Their Pharmaceuti...mentioning

confidence: 99%

Agarwood—The Fragrant Molecules of a Wounded Tree

et al. 2022

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“…Determination of antioxidant activity via DPPH depletion followed the protocol described by Hidayat et al (2021b). The effective concentration at which 50% of the radicals were scavenged (IC 50 value) was obtained by interpolation from the linear regression analysis (Dewi et al, 2013).…”

Section: Antioxidant and Antidiabetic Assaysmentioning

confidence: 99%

Culturable endophytic fungal assemblages from Styrax sumatrana and Stryax benzoin and their potential as antifungal, antioxidant, and alpha-glucosidase inhibitory resources

et al. 2022

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Benzoin resin, produced by the native Indonesian trees Styrax sumatrana and Styrax benzoin, has been incorporated into medical practices to treat wounds, erythema, and many other conditions for centuries. Endophytic fungi that reside within medicinal plants have antimicrobial, antioxidant, and α-glucosidase inhibitory capacities, contributing to plant health and derivative products. In this study, we determined the antifungal, antioxidant, and α-glucosidase inhibitory capacities of endophytic fungal isolates from three different tissues (leaves, bark, and stems) of S. sumatrana and S. benzoin trees. The genera of fungal isolates were determined by phylogenetic analysis of internal transcribed spacer sequences. A total of 58 fungal isolates were classified into 15 different fungal genera from eight taxonomic orders—Hypocreales, Botryosphaeriales, Glomerellales, Diaphortales, Pleosporales, Eurotiales, Xylariales, and Mucorales—with a pattern of host species specificity. Among these isolates, Trichoderma sp. 6407 consistently exhibited high inhibition of the growth of plant pathogens Fusarium sp., Trichoderma viride, and Aspergillus niger. With respect to antioxidant activity, Phyllosticta sp. 6454 consistently showed 2,2-diphenyl-1-picrylhydrazyl inhibition (37.59 ± 0.05%), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid)-based antioxidant activity (25.04 ± 0.27 mgTE/g), and α-glucosidase inhibitory activity (52.15 ± 10.08%). Neopestalotiopsis sp. 6431 was notably potent in 2,2-diphenyl-1-picrylhydrazyl inhibition (49.65 ± 0.80%), ferric reducing antioxidant power-based antioxidant activity (197.49 ± 8.65 mgTE/g), and α-glucosidase inhibitory activity (52.88 ± 4.93%). This study revealed that Trichoderma sp. 6407, Phyllosticta sp. 6454, and Neopestalotiopsis sp. 6431 exhibited antifungal, antioxidant, and α-glucosidase inhibitory activities.

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“…The resin that is produced in response to the infection is normally dark in color. These substances are known as secondary metabolites which play a role in plant defense mechanisms [4]- [6]. Due to the high demand, the prices of the pure agarwood essential oil become expensive.…”

Section: Introductionmentioning

confidence: 99%

k-nearest neighbor modelling of agarwood oil samples available in capital of Malaysia market

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Tajuddin

et al. 2022

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<span>Agarwood oil is consumed during traditional ceremonies and even in medicinal purposes due to its effective therapeutic characteristic. As a part of ongoing research on agarwood oil, this paper presented a k-nearest neighbor (k-NN) modelling of agarwood oil samples available in the capital of Malaysia market. The work involved agarwood oil samples from three sources which are lab, local manufacturer and market. The inputs are the chemical compounds and the output is the oil’s resources. The input-output was divided into training and testing dataset with the ratio of 80% to 20%, respectively, before they were fed to the k-NN for model development as well as model validation. During the model development, the k-value was varied from 1 to 5, and their accuracy was observed. The result showed that the k=1 and k=2 shared the similar accuracy for training and testing datasets, which are 98.63% and 100.00%, respectively. This study revealed the capabilities of the k-NN model in classifying the agarwood oil samples to the three sources: lab, local manufacturer and market. It was a significant study and contributed to further work especially those related to agarwood oil research area.</span>

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Bioactive composition, antifungal, antioxidant, and anticancer potential of agarwood essential oil from decaying logs (Gyrinops spp.) of Papua Island (Indonesia)

Cited by 7 publications

References 7 publications

Agarwood—The Fragrant Molecules of a Wounded Tree

Agarwood—The Fragrant Molecules of a Wounded Tree

Culturable endophytic fungal assemblages from Styrax sumatrana and Stryax benzoin and their potential as antifungal, antioxidant, and alpha-glucosidase inhibitory resources

k-nearest neighbor modelling of agarwood oil samples available in capital of Malaysia market

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