Bioactive composites for bone tissue engineering

Tanner, K.E.

doi:10.1243/09544119jeim823

Cited by 59 publications

(50 citation statements)

References 68 publications

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“…The ultimate goal of TE is to regenerate and replace structural and functional deficits of tissue, beyond its natural healing capacity. For that purpose, external regenerative resources including scaffolds, cells and growth/trophic factors (GF) either alone or in combination are employed (Place et al, 2009;Tanner, 2010;, Rokn et al, 2011). The general strategy of TE uses undifferentiated cells seeded within a scaffold which defines the geometry of the replacement tissues, and provides environmental cues to promote the development of new tissues (Zuk, 2008;,Place et al, 2009;Binderman et al, 2011.).…”

Section: Introductionmentioning

confidence: 99%

Tissue Engineering of Bone: Critical Evaluation of Scaffold Selection

Binderman¹,

Yaffe²,

Samuni³

et al. 2012

Bone Regeneration

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Section: Introductionmentioning

confidence: 99%

Tissue Engineering of Bone: Critical Evaluation of Scaffold Selection

Binderman¹,

Yaffe²,

Samuni³

et al. 2012

Bone Regeneration

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“…With this in mind, composite materials have been widely explored in bone tissue engineering field since it combines two different materials that resulted in an improvement in mechanical properties and osteoconductive properties of bone grafts. This review will be focused on composites that combine ceramic and polymer materials and despite recognizing that these composite scaffolds can be obtained by mixing ceramic powder with a polymer solution and using different manufacturing techniques [17,101,102], ceramic deposition onto polymers [17,103,104] or by polymer deposition onto ceramics [17,[105][106][107][108][109], only the last one will be reviewed.…”

Section: Composite Materialsmentioning

confidence: 99%

Synthetic and Marine-Derived Porous Bone Graft Substitutes

Neto¹,

Ferreira²

2018

Preprint

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Bone is a dynamic tissue with the capacity of repair and regeneration in specific conditions. Nevertheless, due to the increased incidence of bone disorders, the need of bone grafts has been growing over the past decades and the development of a bone graft with optimal properties remains a clinical challenge. This review addresses the bone properties (morphology, composition and their repair and regeneration capacity) and then is focused on the potential strategies for bone repair and regeneration. It describes the requirements for designing a suitable scaffold material, types of materials (polymers, ceramics and composites) and techniques to obtain the porous structures (additive manufacturing techniques/robocasting or derived from marine skeletons) for bone tissue engineering applications. The main objective of this review is to gather the knowledge on the materials and methods for the production of scaffolds for bone tissue engineering and highlight that natural materials, namely the marine skeletons represent a promising alternative.

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“…As scientists started to unravel the communication mechanisms of cells, it was concluded that 2D surfaces were bad models for cell studies, as cell morphology and behavior are greatly influenced by what it senses on all sides (see Figure 6). Alongside other developments in tissue engineering, material scientists and engineers therefore started developing techniques that would allow them to grow cell cultures in-vitro in a 3D environment [1,[27][28][29]. This research partially resulted in a new field within the tissue engineering community that is now known as biofabrication.…”

Section: (Bio)scaffold Fabricationmentioning

confidence: 99%

Plasma Science and Technology - Progress in Physical States and Chemical Reactions

Mieno¹

2016

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Non-thermal plasma technology is one of those techniques that suffer relatively little from diffusion limits, slow kinetics, and complex geometries compared to more traditional liquid-based chemical surface modification techniques. Combined with a lack of solvents, preservation of the bulk properties, and fast treatment times; it is a well-liked technique for the treatment of materials for biomedical applications. In this book chapter, a review will be given on what the scientific community determined to be essential to obtain appropriate scaffolds for tissue engineering and how plasma scientists have used non-thermal plasma technology to accomplish this. A distinction will be made depending on the scaffold fabrication technique, as each technique has its own set of specific problems that need to be tackled. Fabrication techniques will include traditional fabrication methods, rapid prototyping, and electrospinning. As for the different plasma techniques, both plasma activation and grafting/polymerization will be included in the review and linked to the in-vitro/in-vivo response to these treatments. The literature review itself is preceded by a more general overview on cell communication, giving useful insights on how surface modification strategies should be developed.

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Bioactive composites for bone tissue engineering

Cited by 59 publications

References 68 publications

Tissue Engineering of Bone: Critical Evaluation of Scaffold Selection

Tissue Engineering of Bone: Critical Evaluation of Scaffold Selection

Synthetic and Marine-Derived Porous Bone Graft Substitutes

Plasma Science and Technology - Progress in Physical States and Chemical Reactions

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