Bioactive components from <i>Moringa oleifera</i> seeds: production, functionalities and applications – a critical review

Dzuvor, Christian K O; Pan, Sharadwata; Amanze, Charles; Amuzu, Prosper; Asakiya, Charles; Kubi, Francis

doi:10.1080/07388551.2021.1931804

Cited by 55 publications

(34 citation statements)

References 154 publications

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“…For instance, the in vitro cytotoxicity and genotoxicity of MOSE using the cell bioreporter model has been reported (Al-Anizi et al, 2014). To the best of our knowledge, this work represents the first report on the effect of MOSE aqueous extracts on fertility and pregnancy outcomes in rodents; although flocculant high molecular weight proteins have been characterized in Moringa seed kernel (Gassenschmidt et al, 1995;Ghebremichael et al, 2005;Dzuvor et al, 2022), we further report that MOSE seed kernel is rich in peptides and proteins as indicated by the findings from protein proximate analysis and the preliminary MALDI TOF-guided peptide detection. These numerous peptides are likely hydrolysates of bigger proteins which have been released during the harsh solvent-based extraction process.…”

Section: Discussionmentioning

confidence: 87%

“…Polypeptides present in the seeds have been implicated as the main flocculant molecules ( Ghebremichael et al, 2005 ). Other secondary compounds isolated from the seed are lipids and glycosides including O -ethyl-4-(α-L-rhamnosyloxy) benzyl carbamate, 4(α-L-rhamnosyloxy)-benzyl isothiocyanate, niazimicin, 3- O -(6′- O -oleoyl-β-D-glucopyranosyl)-β-sitosterol, β-sitosterol-3- O -β-D-glucopyranoside, niazirin, β-sitosterol and glycerol-1-(9-octadecanoate) ( Guevara et al, 1999 ; Dzuvor et al, 2022 ). Some of the Moringa fatty acids and lipids have been reported as phytochemical agents with uterotonic potential ( Gruber and O'Brien, 2011 ) making their intake potentially unsafe during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

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Moringa oleifera Seed at the Interface of Food and Medicine: Effect of Extracts on Some Reproductive Parameters, Hepatic and Renal Histology

et al. 2022

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The lipid-rich Seed of Moringa oleifera has been promoted as an effective water clarifier. Aside its vital nutritional application as an emerging food additive, the seed has continued to gain a wider acceptance in various global ethnomedicines for managing several communicable and lifestyle diseases, howbeit, its potential toxic effect, particularly on fertility and pregnancy outcomes has remained uninvestigated; the effect of Moringa oleifera seed (MOSE) aqueous-methanol extracts on fertility and pregnancy outcome, was investigated in vivo using female Wistar rats that were divided into 50, 100, 300 and 500 mg per kilogram body weight. Group six was given Moringa oleifera seed treated water ad-libitum (ad-libitum group). Organs harvested for histological assessment included ovary, uterus, liver and kidney. In addition to HPLC fingerprint and a preliminary peptide detection, we determined the physico-chemical characteristics and mineral content of MOSE using standard methods. Data were analyzed with significance at p ≤ 0.05. There was no significant difference in the estrus cycle, mating index, gestation survival index, gestation index, fertility index and sex ratio among all groups. Gestation length was reduced in some groups. While the male pup birth weight was comparable among the different groups, female pups birth weights were significantly reduced in 50 and 100 mg groups. Anogenital distance indices of female pups in ad libitum group were significantly increased. Pathologies were observed in liver and kidneys of dams while kidneys of pups presented a dose dependent reduction in the number of glomeruli. There were no observed pathological changes in the ovary and uterus. This study showed for the first time in rodents, that the lipid-rich MOSE is unsafe to the kidney of rodents while the lipid-free MOSE appears to be safe at doses up to 300 mg/kg body weight. Findings from this study suggested that the female pups were masculinized. In conclusion, the lipid-rich seed extracts of MOSE appear to be unsafe during pregnancy, induce hepatic and renal toxicity while the lipid-free MOSE excludes inherent toxicity as the hydrophobic part has been linked to toxicity as observed in this study due to the developmental programming effect on female offspring in rodents.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Moringa oleifera Seed at the Interface of Food and Medicine: Effect of Extracts on Some Reproductive Parameters, Hepatic and Renal Histology

et al. 2022

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“…An extensive literature survey on Moringa suggested that Ancient Egyptians used Moringa oil because of its cosmetic value, which helps in human skin preparation Khan, et al (2017). Moringa seeds have therapeutic characteristics increase the health benefits and the pharmacological potentials including: antimicrobial, antioxidant, antidiabetic, antitumor, antihypertensive, antiinflammatory and cardio-protective properties Abdulwaliyu et al (2019); and Dzuvor et al (2021).…”

Section: Introductionmentioning

confidence: 99%

“…On the other side, the Moringa seeds boast high nutritional value, which is attributed to its significant biologically active components, such as flavonoids, phenolic acids, saponins, tannins, isothiocyanate, vitamins, and minerals; however, some of these components are considered as antinutritional factors. Some other phytochemical constituents have been reported to interfere with protein digestion and normal metabolism, which inhibit the growth performance, and decrease the body weight when used as food for animals Igwilo et al (2010); Annongu et al (2014);and Dzuvor et al (2021).…”

Section: Introductionmentioning

confidence: 99%

Effect of Soaking Process on Chemical Characteristics and Anti Nutritional Factors of some Moringa Seed Varieties

El-Anoos

Fahmy

Mahmoud

et al. 2022

Journal of Food and Dairy Sciences

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Moringa seeds have high medicinal and value nutritional. This is mainly to the large stock of biologically active ingredients in seeds. With the global shortage of food grains, the incidence of nutritional deficiency diseases and the ever-increasing population, Moringa in particular will certainly provide a good alternative to make up for the food shortage. This research aimed to study the effect of soaking process in water and in NaOH 0.5% solution on the Moringa seeds. Gross chemical composition, minerals, anti nutritional and fatty acid of M. oleifera and peregrina seeds were investigated. In general, Soaking has a significant (p <0.05) effect on the gross chemical of M. oleifera M. peregrina seeds. There is a large variation in minerals value both of raw and soaked Moringa oleifera and Moringa peregrina kernels. Results revealed that crude extract obtained from both of raw Moringa (oleifera and peregrina) seeds showed that there was a significant difference in anti-nutritional content before and after soaking. The aqueous soaking treatment was more effective than soaking with alkali solution NaOH 0.5% to remove anti nutritional factors. Furthermore, fatty acid oleic (C18:1) represented the highest proportion of fatty acids. Results indicated that soaking processes caused a significant decrease in total unsaturated fatty acids content, accompanied by an apparent increase in the total saturated fatty acids of M. oleifera and Peregrina seeds.

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“…Moringa oleifera is a native plant to Southern Asia and is the most widely cultivated species of the Moringa genus. Most parts can be used as food, as they are a high source of protein, essential amino acids, minerals and vitamins [9,10]. It is a multipurpose tree with important economic value around the world, as its leaves, flowers and seeds can be used by the agro-food and biochemical industries.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Metabolomic Profile and Growth of Moringa oleifera L. Cultivated with Vermicompost under Different Soil Types

et al. 2021

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Moringa oleifera is a highly versatile plant with potential use in the agro-food and biochemical industry. The goals of this study were to evaluate the effect of chemical fertilization and vermicompost on plant growth, and to analyze the metabolomic profile of M. oleifera crops cultivated over agricultural and native soils. The extracts were obtained from 90-day-old leaves via extraction with a hydroalcoholic mixture. Multivariate data analyses, such as principal component analysis (PCA) and partial least square-discriminant analysis (PLS-DA), were used to differentiate the distribution of leaf metabolites according to the soils or types of fertilizers used for the cultivation of Moringa oleifera. The results indicated that there was no significant effect on parameters such as plant height, root length and dry weight of leaves (p < 0.05). UPLC-ESI-MS/MS analysis of leaf extracts revealed a wide range of flavonoids, alkaloids and organic acids. The results of PCA and PLS-DA confirmed that the type of fertilizer had an effect on the metabolomic profile of M. oleifera leaves. The application of vermicompost induced changes in the metabolomic profile, but not in the morphometric variables of Moringa oleifera. These results are important for metabolite production via organic cultures and over different soil types in the industrialization of Moringa.

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Bioactive components from Moringa oleifera seeds: production, functionalities and applications – a critical review

Cited by 55 publications

References 154 publications

Moringa oleifera Seed at the Interface of Food and Medicine: Effect of Extracts on Some Reproductive Parameters, Hepatic and Renal Histology

Moringa oleifera Seed at the Interface of Food and Medicine: Effect of Extracts on Some Reproductive Parameters, Hepatic and Renal Histology

Effect of Soaking Process on Chemical Characteristics and Anti Nutritional Factors of some Moringa Seed Varieties

Evaluation of Metabolomic Profile and Growth of Moringa oleifera L. Cultivated with Vermicompost under Different Soil Types

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