Bioactive Coating of Titanium Surfaces with Recombinant Human β-Defensin-2 (rHuβD2) May Prevent Bacterial Colonization in Orthopaedic Surgery

Pfeufer, Nadine Y.; Hofmann-Peiker, Karsten; Muhle, Mike; Warnke, Patrick H.; Weigel, Martin C.; Kleine, Michael

doi:10.2106/jbjs.i.01738

Cited by 24 publications

(15 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, Pfeufer et al report the effectiveness of titanium surfaces coated with recombinated HBD-2 with respect to antibacterial activity and suggest that this may be a promising tool for treating infections related to prosthetic implant surgery [126]. Our own studies show promising results with the HBD-2 coating of a Kirschner-wire (Figure 3).…”

Section: Practical Applicationsmentioning

confidence: 68%

Antimicrobial Peptides: Multifunctional Drugs for Different Applications

et al. 2012

View full text Add to dashboard Cite

Antimicrobial peptides (APs) are an important part of the innate immune system in epithelial and non-epithelial surfaces. So far, many different antimicrobial peptides from various families have been discovered in non-vertebrates and vertebrates. They are characterized by antibiotic, antifungal and antiviral activities against a variety of microorganisms. In addition to their role as endogenous antimicrobials, APs participate in multiple aspects of immunity. They are involved in septic and non-septic inflammation, wound repair, angiogenesis, regulation of the adaptive immune system and in maintaining homeostasis. Due to those characteristics AP could play an important role in many practical applications. Limited therapeutic efficiency of current antimicrobial agents and the emerging resistance of pathogens require alternate antimicrobial drugs. The purpose of this review is to highlight recent literature on functions and mechanisms of APs. It also shows their current practical applications as peptide therapeutics and bioactive polymers and discusses the possibilities of future clinical developments.

show abstract

Section: Practical Applicationsmentioning

confidence: 68%

Antimicrobial Peptides: Multifunctional Drugs for Different Applications

et al. 2012

View full text Add to dashboard Cite

show abstract

“…They include groups of synthetic peptide mimetics, hybrid peptides, peptide congeners, stabilized peptides, peptide conjugates, and immobilized peptides [56]. Natural, as well as synthetic AMPs derived from lactoferrin [52,57], LL-37 [58], and beta defensins [59], may be active against Candida species and other microorganisms, and have the potential to be applied in bioactive implant coatings (Table 4).…”

Section: Amps In Bioactive Coatingsmentioning

confidence: 99%

Antimicrobial Prosthetic Surfaces in the Oral Cavity—A Perspective on Creative Approaches

et al. 2020

View full text Add to dashboard Cite

Replacement of missing teeth is an essential component of comprehensive dental care for patients suffering of edentulism. A popular option is implant-supported restorations. However, implant surfaces can become colonized with polymicrobial biofilms containing Candida species that may compromise peri-implant health. To prevent this, implant components may be treated with a variety of coatings to create surfaces that either repel the attachment of viable microorganisms or kill microorganisms on contact. These coatings may consist of nanoparticles of pure elements (more commonly silver, copper, and zinc), sanitizing agents and disinfectants (quaternary ammonium ions and chlorhexidine), antibiotics (cefalotin, vancomycin, and gentamicin), or antimicrobial peptides (AMPs). AMPs in bioactive coatings have a number of advantages. They elicit a protective action against pathogens, inhibit the formation of biofilms, are less toxic to host tissues, and do not prompt inflammatory responses. Furthermore, many of these coatings may involve unique delivery systems to direct their antimicrobial capacity against pathogens, but not commensals. Coatings may also contain multiple antimicrobial substances to widen antimicrobial activity across multiple microbial species. Here, we compiled relevant information about a variety of creative approaches used to generate antimicrobial prosthetic surfaces in the oral cavity with the purpose of facilitating implant integration and peri-implant tissue health.

show abstract

“…Phase II studies in 134 patients in bone marrow transplantation centres showed that IB-367 reduced post-transplantation mucositis to 22% from the 40% incidence it was assessed at when treatment was initiated four days prior to bone marrow transplantation [29]. Pfeufer et al [30] demonstrated the effectiveness of coating titanium surfaces with recombinant HBD-2 in the elimination of infections associated with the implantation of prosthetic. It has been shown that amphiphilic peptides covalently bound to a water-insoluble resin retain antimicrobial activity for a long time [31], and hence, in such a form can be used for the disinfection of medical equipment, including catheters.…”

Section: The Application Of Peptides In Ophthalmologymentioning

confidence: 99%

Utilisation of peptides against microbial infections – a review

Mirski

Niemcewicz

Bartoszcze

et al. 2017

Ann Agric Environ Med.

View full text Add to dashboard Cite

The emergence of resistance in microorganisms on a global scale has made it necessary to search for new antimicrobial factors. Antimicrobial peptides (AMPs) seem to meet these expectations. AMPs are produced by bacteria, viruses, plants, and animals, and may be considered as a new class of drugs intended for the prophylaxis and treatment of both systemic and topical infections. The aim of this study is to review the results of studies on the use of peptides to combat infections in vivo. Antimicrobial peptides may be applied topically and systemically. Among the peptides used topically, a very important area for their application is ophthalmology. AMPs in ophthalmology may be used mainly for the protection of contact lenses from ocular pathogens. Many AMPs are in clinical trials for application in the therapy of local infections. There may be mentioned such preparations as: pexiganan (magainin analogue), MX-226 (based on indolicidin), NEUPREX (isolated from human BPI (bactericidal/permeability-increasing) protein), IB-367 (variant of porcine protegrin), P113 (based on histatin), daptomycin, polymyxins, as well as peptidomimetics. In the combat against systemic infections are used such peptides as: P113D (modified P113 peptide containing D-amino acids), colistin, peptoids, and peptides containing non-typical amino acids or non-peptide elements. AMPs are also used as antiprotozoal, antifungal, antitoxic and immunostimulatory agents. The limitations in the use of peptides in the treatment of infections, such as susceptibility to proteolysis, and resistance of microorganisms to the peptides, are also discussed. AMPs are a promising strategy in the fight against microbial infections.

show abstract

Bioactive Coating of Titanium Surfaces with Recombinant Human β-Defensin-2 (rHuβD2) May Prevent Bacterial Colonization in Orthopaedic Surgery

Abstract: Natural antibiotics such as rHuβD2 integrated into the metal surface of titanium implants may be a promising tool to prevent and control infections around orthopaedic implants.

Cited by 24 publications

References 33 publications

Antimicrobial Peptides: Multifunctional Drugs for Different Applications

Antimicrobial Peptides: Multifunctional Drugs for Different Applications

Antimicrobial Prosthetic Surfaces in the Oral Cavity—A Perspective on Creative Approaches

Utilisation of peptides against microbial infections – a review

Contact Info

Product

Resources

About