Bioactive cis-stilbenoids from the tubers of Scirpus yagara

Liang, Qiaoli; Lei, Lingling; Cui, Xiaodong; Zou, Nuo-Shu; Duan, Jin‐Ao

doi:10.1016/j.fitote.2012.11.012

Cited by 13 publications

(17 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been demonstrated that high concentrations of SsnB have no toxic effects on macrophages in rats with sepsis (15). Therefore, it was speculated that it may induce no side effect in the ICH model.…”

Section: Discussionmentioning

confidence: 99%

“…The current study did not measure the side effects of SsnB; therefore, it remains unknown whether SsnB induces side effects in a mouse model of ICH and further studies are required. SsnB has a low molecular weight and high lipid solubility, which facilitates its ability to cross the blood brain barrier and target an ICH-induced inflammatory response (15,16). Therefore SsnB may be developed as a potential method of treating patients with ICH.…”

Section: Discussionmentioning

confidence: 99%

“…SsnB treatment. SsnB was extracted and prepared from the rhizome of the Chinese herb Scirpus yagara (Kangmei Century Chinese Medicine Co. Ltd., Bozhou, China) as described previously (14,15). Scirpus yagara was widely used in traditional Chinese medicine (14).…”

Section: Morris Water Maze (Mwm)mentioning

confidence: 99%

“…SsnB affects the expression of signaling molecules associated with TLR4. Previous studies indicated that SsnB suppressedTLR4-mediated inflammatory reaction in an LPS-induced sepsis mouse model (14,15). To further evaluate the underlying neuroprotective mechanism of SsnB in ICH, western blotting was performed to examine the expression of signaling molecules downstream of TLR4.…”

Section: Ssnb Reduces Brain Edema and The Expression Of Inflammatory mentioning

confidence: 99%

“…Previous studies have demonstrated that Sparstolonin B (SsnB), a natural compound extracted from the Chinese herb Scirpus yagara, may block the recruitment of MyD88 by TLR4 (14,15). MyD88 is critical for the TLR signaling pathway; inhibition of MyD88 results in the inhibition of the TLR signaling pathway and subsequently decreases Sparstolonin B improves neurological outcomes following intracerebral hemorrhage in mice inflammation (14).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Sparstolonin B improves neurological outcomes following intracerebral hemorrhage in mice

Wang¹,

Jiang²,

Xiao³

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

Abstract. Inflammation serves an important role in inducing secondary injury following intracerebral hemorrhage (ICH).It has been demonstrated that sparstolonin B (SsnB) is able to attenuate the lipopolysaccharide-induced inflammatory response in sepsis. Mouse ICH models were used to explore the efficacy of SsnB on the ICH-induced inflammatory response. Mice underwent a working memory version of Morris water maze (MWM) test. They underwent 5 successive days of training consisting of 4 trials each day. The ICH model was established on the last training day. Mice were injected intraperitoneally either with vehicle or SsnB once a day for 3 consecutive days following the establishment of the ICH model. The MWM was used to determine the effect of SsnB on short-term memory following ICH. Neurological deficit scores and brain water content were measured following the MWM. Furthermore, the expression of inflammatory factors and signaling molecules downstream of TLR4 were measured. The results demonstrated that 5 mg/kg SsnB significantly improved the MWM path and time latency (P<0.05). Furthermore, neurological deficit scores were decreased in SsnB-treated mice compared with vehicle-treated mice (P<0.01). Brain water content, levels of inflammatory cytokines and the expression of inflammation-associated proteins were also significantly reduced in the SsnB-treated group (P<0.05). These results indicate that SsnB treatment stimulates short-term neurobehavioral recovery and reduces neurological deficits and this may inhibit the inflammatory response. Therefore, SsnB may attenuate the inflammatory response following ICH.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Morris Water Maze (Mwm)mentioning

confidence: 99%

Section: Ssnb Reduces Brain Edema and The Expression Of Inflammatory mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sparstolonin B improves neurological outcomes following intracerebral hemorrhage in mice

Wang¹,

Jiang²,

Xiao³

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

show abstract

Determination of sparstolonin B by ultra‐high performance liquid chromatography coupled with triple quadrupole mass spectrometry: application to pharmacokinetic study of sparstolonin B in rat plasma

Zou

Liang

et al. 2015

Biomedical Chromatography

Self Cite

View full text Add to dashboard Cite

Sparstolonin B (SsnB), a spontaneous isocoumarin compound isolated from the tuber of Scirpus yagara Ohwi. (Cyperaceae), possesses potent anti-inflammatory and antitumor activity. In the present study, a rapid and simple UHPLC/MS/MS method for determination of SsnB in rat plasma was developed and validated. Plasma samples were pretreated by liquid-liquid extraction with ethyl acetate containing rhein as an internal standard and separated on a C18 column at 35 °C, with a gradient mobile phase consisting of acetonitrile and water containing 0.2% (v/v) formic acid within 2.1 min. MS/MS detection was accomplished in multiple reaction monitoring mode with negative electrospray ionization. The precursor-product ion transitions were m/z 266.9 [M-H](-) → m/z 211.0 for SsnB and m/z 283.2 [M-H](-) → m/z 239.0 for IS. The intra- and inter-day precision (RSD) was <8.98% and the accuracy (RE) ranged from -7.40 to 4.50%. The extraction recoveries ranged from 96.28 to 97.30%. The pharmacokinetic parameters were calculated using Win Nonlin53 software. The absolute bioavailability of SsnB was estimated to be 6.98%. The proposed method was successfully applied to a pharmacokinetic study of SsnB in rats after intravenous administration with a dose of 0.5 mg/kg and oral administration at a dose of 5 mg/kg.

show abstract

Structural Modification of Stilbenoids from Acanthopanax leucorrhizus and Their Cytotoxic Activity

Liang²,

et al. 2017

Chemistry & Biodiversity

View full text Add to dashboard Cite

A new cis-stilbenoid, 1,9-dihydroxy-10-methoxy-6H-dibenzo[b,f]oxocin-6-one (2) was isolated from the AcOEt extract of the stem barks of Acanthopanax leucorrhizus, along with three known stilbenoids, 9-hydroxy-10-methoxy-6H-dibenzo[b,f]oxocin-6-one (1), 5-O-methyl-(E)-resveratrol 3-O-β-d-glucopyranoside (3), and (E)-resveratrol 3-O-β-d-xylopyranoside (4). Two derivatives (2a and 2b) were synthesized by the structural modification of compound 2, which exhibited certain cytotoxic activities against HT-29 and HeLa cell lines in vitro. All compounds were structurally characterized by comprehensive analysis of their spectroscopic data and comparison with literature information, and evaluated for their cytotoxic activities against three human tumor cell lines (HL-60, HT-29, and HeLa) by the standard MTT assay in vitro. The results showed that derivatives 2a and 2b exhibited strong activities than compounds 2 against HT-29 and HeLa cell lines.

show abstract

Bioactive cis-stilbenoids from the tubers of Scirpus yagara

Cited by 13 publications

References 19 publications

Sparstolonin B improves neurological outcomes following intracerebral hemorrhage in mice

Sparstolonin B improves neurological outcomes following intracerebral hemorrhage in mice

Determination of sparstolonin B by ultra‐high performance liquid chromatography coupled with triple quadrupole mass spectrometry: application to pharmacokinetic study of sparstolonin B in rat plasma

Structural Modification of Stilbenoids from Acanthopanax leucorrhizus and Their Cytotoxic Activity

Contact Info

Product

Resources

About