Background: Ultra-Opaque resin cement is a promising material introduced in the market aiming to mask discolored substrates such as tooth, titanium implants, and metallic posts. Aim: To evaluate the masking ability of the ultra-opaque resin cement to different discolored substrates.Material and Methods: Sixty ceramic disks were fabricated with three ceramic materials (Lithium disilicate, zirconia reinforced lithium disilicate, and ultra-translucent zirconia) (N=20 each).Ceramic disks were cemented to Ni-Cr disks using two adhesive resin cements (Conventional resin cement and ultra-opaque resin cement). Color measurements were done before and after cementation and after thermocycling using spectrophotometer based on CIE L* a* b* relative to the standard illumination D65.Color difference was obtained by calculating the difference in color measurements using the formula ∆E=[(∆L*)2 +(∆a*)2 +(∆b*)2] ½. Results: After thermocycling, ultra-opaque cement showed lower mean ∆E compared to conventional resin cement.Conventional resin cement showed a lower mean ∆E than the ultra-opaque one with the Katana group, while there was no statistically significant difference among other groups. Conclusions: whatever type of ceramic used, ultra-opaque resin cement has a higher masking ability than conventional resin cement.