Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans

Abstract

Four new cembranoids, sarcophelegans A-D (1-4) and six known analogues (5-10) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were elucidated through detailed spectroscopic analysis, and the absolute configuration of 1 was confirmed by single-crystal X-ray diffraction. The antimigratory potential of compounds 1-10 were evaluated and compounds 2 and 6 were found to inhibit human breast tumor MDA-MB-231 cell migration at 10 μM.

Marine natural products

“…827 and 1171 (Litophyton arboreum), 809 hydroperoxycembranoid 1172 (Sarcophyton trocheliophorum), 828 and 1173-1177 (Sinularia sandensis and S. exibilis). 829 X-ray studies were used to determine the complete structural and stereochemical characterization of sarcophelegan A 1164, 825 cembranoid 1173 and isosinulaexiolide K 1177. 829 X-ray studies were also used to conrm the structures and conguration of previously reported cembranoids sarsolilide B (Sarcophyton trocheliophorum) 826,830 pukalide (Leptogorgia alba) 831 and dendronpholide F (Dendronephthya sp.)…”

New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sarcophyton ehrenbergi

“…Our previous chemical investigations on soft corals belonging to the genus Sarcophyton (Alcyoniidae), collected off the waters of the South China Sea, have obtained a series of marine natural products, including prostaglandin derivatives [1], sarsolenane-, capnosane- and cembrane-type diterpenoids [2,3,4]. These chemical components, especially cembranes, possessed various bioactivities such as anti-protozoal [5], cytotoxic [6,7], antiviral [8], and anti-inflammatory [9,10] properties, which have motivated natural product researchers to search for potential drug leads.…”

Draft Genome Sequence of Novosphingobium sp. Strain HII-3, a Bacterium Capable of Degrading the Cembranoid α(β)-2,7,11-Cembratriene-4,6-Diol to Farnesal

“…Cembranoids are 14-carbon cembrane ring cyclic diterpenoids ( 1 ). They are distributed primarily in the genera Nicotiana and Pinus and in some marine organisms (e.g., soft coral), in which they are thought to play a key role in survival ( 2 – 4 ). Cembranoids have many important bioactivities, including antimicrobial, antitumor, and neuroprotective activities ( 5 – 7 ).…”