Bioactive CaTiO3 film prepared on the biomedical porous Ti–15Mo alloy by one-step hydrothermal treatment

Lai, Tao; Xu, J.L.; Cao, Xun; Bao, L.Z.; Luo, Junming; Huang, Yong

doi:10.1016/j.jmrt.2021.06.065

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…Tat may be due to the fact that CaTiO 3 can emit the Ca 2+ ion that promotes positive reactions with cells. Calcium titanate was also reported to polarize the coated surface, enhancing cell activity [9,50].…”

Section: Contact Anglementioning

confidence: 99%

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Metallic Implant Surface Activation through Electrospinning Coating of Nanocomposite Fiber for Bone Regeneration

Al-Khateeb

Al-Hassani

Jabur

2023

International Journal of Biomaterials

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There is a critical need in orthopedic and orthodontic clinics for enhanced implant-bone interface contact to facilitate the quick establishment of a strong and durable connection. Surface modification by bioactive multifunctional materials is a possible way to overcome the poor osteoconductivity and the potential infection of Ti-based implants. Ti-25Zr biometallic alloy was prepared by powder metallurgy technique and then coated by Nano-composite fiber using electrospinning. Ceramic Nanocompound (CaTiO3, BaTiO3) was used as filler material and individually added to polymeric matrices constructed from the blend of polycaprolactone/chitosan. Using optical microscopy, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FTIR), and wettability, respectively, the morphology, chemical analysis, surface roughness, and contact angle measurements of the samples were evaluated. The result shows a significant improvement in cell viability, proliferation, and ALP activity for coated samples compared to noncoated samples. PCL/Chitosan/Nano-CaTiO3 (CA1) recorded remarkable enhancement from the surface-coated samples, demonstrating a significantly higher cell viability value after seven days of MC3T3-E1 cell culture, reaching 271.56 ± 13.15%, and better cell differentiation with ALP activity reaching 5.61 ± 0.35 fold change for the same culture time. PCL/Chitosan/Nano-BaTiO3 (BA1) also shows significant improvement in cell viability by 181.63 ± 17.87% and has ALP activity of 3.97 ± 0.67 fold change. For coated samples, cell proliferation likewise exhibits a considerable temporal increase; the improvement reaches 237.53% for (CA1) and 125.16% for (BA1) in comparison with uncoated samples (bare Ti-25Zr). The coated samples resist bacteria in the antibacterial test compared to the noncoated samples with no inhibition zone. This behavior suggests that a Nanocomposite fiber coat containing an active ceramic Nanocompound (CaTiO3, BaTiO3) promotes cell growth and holds promise for orthodontic and orthopedic bioapplication.

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Section: Contact Anglementioning

confidence: 99%

“…Additionally, titanium alloys are produced in regulated porous structures, which successfully lower the implant's modulus of elasticity to levels comparable to those of natural bone. Also, it permits new bone to grow within that porous area and achieve mechanical interlocking [9,10].…”

Section: Introductionmentioning

confidence: 99%

Metallic Implant Surface Activation through Electrospinning Coating of Nanocomposite Fiber for Bone Regeneration

Al-Khateeb

Al-Hassani

Jabur

2023

International Journal of Biomaterials

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“…Because of the inert surface of these alloys, one of the main challenges is the insufficient integration of the materials with the natural tissue around them. An implant material's poor biointegration is frequently linked to unsatisfactory long-term medical results [ [7] , [8] , [9] ].…”

Section: Introductionmentioning

confidence: 99%

Active nanoceramic compound dipped in biopolymers to create composite coating for metallic implant surface

Al-Khateeb,

Al-Hassani,

Jabur

2023

Heliyon

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Novel Chemical Treatment of Porous Titanium Structures for Nanotextured Surface and Bioactive Behavior

Ferraris,

Alidoost,

Spriano

et al. 2024

Adv Eng Mater

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Macroporous titanium structures are of interest in bone reconstruction because of their reduced modulus of elasticity (compared to bulk titanium), possibility of being colonized by cells, and biocompatibility. However, they are not bioactive and are not able to actively facilitate bone ingrowth or reduce bacterial adhesion. In the present research, work porous titanium scaffolds with different features (porosity 30–60 vol% and pore size 100–200 or 355–500 μm) are obtained by the space holder technique. Samples are characterized using optical microscopy, computed tomography, scanning electron microscopy (SEM), and X‐ray diffraction. Moreover, the theoretical elastic modulus and yield strength are calculated. A patented chemical treatment, able to produce a bioactive nanotextured oxide layer, has been optimized and successfully applied, for the first time, to structures with 50 vol% porosity and 100–200 μm pore size (as the most promising for bone substitution due to the biomechanical and biofunctional balance). Bare and modified samples are characterized using field emission SEM, zeta potential measurements, and in vitro bioactivity tests (soaking in simulated body solution) to evaluate the effectiveness of the surface chemical treatment.

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Bioactive CaTiO3 film prepared on the biomedical porous Ti–15Mo alloy by one-step hydrothermal treatment

Cited by 5 publications

References 42 publications

Metallic Implant Surface Activation through Electrospinning Coating of Nanocomposite Fiber for Bone Regeneration

Metallic Implant Surface Activation through Electrospinning Coating of Nanocomposite Fiber for Bone Regeneration

Active nanoceramic compound dipped in biopolymers to create composite coating for metallic implant surface

Novel Chemical Treatment of Porous Titanium Structures for Nanotextured Surface and Bioactive Behavior

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