Bioactive calcium sulfate/magnesium phosphate cement for bone substitute applications

Yang, Guangtao; Liu, Jianli; Li, Fan; Pan, Zongyou; Ni, Xiao; Shen, Yue; Xu, Huazi; Huang, Qing

doi:10.1016/j.msec.2013.10.016

Cited by 64 publications

(49 citation statements)

References 49 publications

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“…It does not elicit an obvious foreign body response after implantation in the human body. Thus, it has wide application prospects in unstable fracture treatment and artificial joint prosthesis bond fixation . This study shows that composite calcium phosphate cements and MPBCs have good biocompatibility and osteogenic in vivo .…”

Section: Introductionmentioning

confidence: 83%

Affecting mechanism of chitosan on water resistance of magnesium phosphate cement

Liao

Duan

et al. 2017

Int J Applied Ceramic Tech

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To solve the problem of poor water resistance and restricted usage of magnesium phosphate cement, the cement prepared by NaH 2 PO 4 and NH 4 H 2 PO 4 was modified via chitosan, and the modification mechanism was also explored. The results showed that the optimum molar ratio of NaH 2 PO 4 : NH 4 H 2 PO 4 was 2:3. Upon setting the chitosan content of wt.1%, the mechanical strength of the resulting cements after 28 days was 42 MPa. After water immersion, the percentage of the lost mechanical strength of cements and mass loss was smaller than those in the control group. Free amino group on the molecular chain of chitosan could react with Mg 2+ ions to form complexes. Interconnected polymer network structure was formed in magnesium phosphate bone cement paste. Magnesium phosphate bone cement had hydration products with Mg 2+ ions as nucleation sites, which further gradually formed a network structure, indicating that chitosan could improve the water resistance of magnesium phosphate bone cements. K E Y W O R D S cement, degradation, magnesium oxide, phosphate

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Section: Introductionmentioning

confidence: 83%

Affecting mechanism of chitosan on water resistance of magnesium phosphate cement

Liao

Duan

et al. 2017

Int J Applied Ceramic Tech

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“…Compared to the CSD‐deficient microspheres (SA‐1), the targeted composite microsphere with CSD (SA‐2) were highly interactive when tested for in vitro bioactivity during incubation in the SBF solution. The faster dissolution of calcium sulfate crystals accelerated the calcium‐ion diffusion from the agarose matrix, which increased the polymer erosion and produced a rough surface with a porous microstructure . Consequently, mass loss from SA‐2 was increased in in vitro degradation and an acidic pH was achieved.…”

Section: Discussionmentioning

confidence: 99%

“…The faster dissolution of calcium sulfate crystals accelerated the calcium-ion diffusion from the agarose matrix, which increased the polymer erosion and produced a rough surface with a porous microstructure. 19,30 Consequently, mass loss from SA-2 was increased in in vitro degradation and an acidic pH was achieved. Furthermore, immediate protein adsorption and diffusion allowed the microspheres' surface to interact with molecules and ions from the microenvironment, which ensured the acceptance of materials by the biological body.…”

Section: Discussionmentioning

confidence: 99%

Preparation and evaluation of BCP‐CSD‐agarose composite microsphere for bone tissue engineering

et al. 2019

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Composite microspheres have been widely investigated over the years in order to achieve a sound scaffold with suitable combinations of biodegradable polymers and bioactive ceramics/glasses for bone tissue engineering. In our present study, composite microspheres were prepared for the first time by agarose (1 wt %) enforcement with combination of biphasic calcium phosphate (BCP; 20 wt %) and calcium sulfate dehydrate (CSD; 20 wt %), and analyzed for use in bone regeneration. The one‐step fabrication process revealed spheres of sizes ranging from 50 to 1000 μm of BCP‐CSD contents effectively formed by natural solidification of agarose matrix, which is very simple, time and cost‐effective, and could allow for large scale production. Furthermore, the BCP‐CSD‐agarose composite microspheres were tested in in vitro and in vivo for bone‐forming properties in order to assess their biocompatibility. The rapid diffusion of Ca 2+ ions from CSD of the composite microspheres through agarose matrix potentially increased interactivity with microenvironment and gave support for cell adhesion and proliferation. Moreover, in vivo result demonstrated that fabricated microspheres promoted neovascularization, stimulated fibroblast cell proliferation, and host cell migration occurred throughout the defects and within microspheres, ultimately guided to new bone formation. The developed composite microspheres with novel approach could have potential for bone regeneration application. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2263–2272, 2019.

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“…In the knee, the cartilage and subchondral bone are affected by a variety of diseases such as traumatic osteochondral defects, osteochondritis dissecans, osteonecrosis, and osteoarthritis [1]. A growing understanding of the pathophysiology of knee osteoarthritis has led researchers to redefine osteoarthritis as a degeneration of both the articular cartilage and subchondral bone.…”

Section: Discussionmentioning

confidence: 99%

“…The most widely used classic bone cement is poly(methyl methacrylate) (PMMA) and most widely used BSMs are calcium phosphate (CaP) based. PMMA is indicated for the fixation of prostheses, fixation of fractures, and void filling for reinforcement of living bone during orthopedic procedures [1][2][3]. PMMA is known for its strength and permanence, but unpopular for its handling properties and the peripheral damage to the living bone during the exothermic setting reaction [4,5].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the injection behavior of commercially available bone BSMs for Subchondroplasty® procedures

et al. 2015

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Bioactive calcium sulfate/magnesium phosphate cement for bone substitute applications

Cited by 64 publications

References 49 publications

Affecting mechanism of chitosan on water resistance of magnesium phosphate cement

Affecting mechanism of chitosan on water resistance of magnesium phosphate cement

Preparation and evaluation of BCP‐CSD‐agarose composite microsphere for bone tissue engineering

Assessment of the injection behavior of commercially available bone BSMs for Subchondroplasty® procedures

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