Bioactive Biomaterials: Potential for Application in Bone Regenerative Medicine

Najdanović, Jelena G.; Rajković, Jovana; Najman, Stevo

doi:10.1007/978-3-319-68025-5_12

Cited by 8 publications

(7 citation statements)

References 152 publications

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“…24 The intense absorption bands corresponding to the internal molecular vibrations of the phosphate group (PO 4 3− ) were detected in all samples (Table III). The triplet bands at 1900-2050 cm −1 of weak intensity are related to a combination of ν 3 and ν 1 vibration mode of PO 4 3−28 (Fig. 25 The intense absorption bands at 1047 and 963 cm −1 correspond to ν 3 mode (P─O) asymmetric bending and stretching and ν 1 mode symmetric stretching vibration of PO 4 3− , respectively.…”

Section: Functional Groups Characterizationmentioning

confidence: 96%

“…26,27 Also, ν 2 mode (O─P─O) bending vibration was detected at 473 cm −1 . The triplet bands at 1900-2050 cm −1 of weak intensity are related to a combination of ν 3 and ν 1 vibration mode of PO 4 3−28 ( Fig. 3).…”

Section: Functional Groups Characterizationmentioning

confidence: 97%

“…These vibrations are referred to as bending mode, symmetric and asymmetric stretch. 25 The intense absorption bands at 1047 and 963 cm −1 correspond to ν 3 mode (P─O) asymmetric bending and stretching and ν 1 mode symmetric stretching vibration of PO 4 3− , respectively. The double bands at 602 and 571 cm −1 were due to triple ν 4 mode (O─PO) symmetric and asymmetric bending vibration of PO 4 3− .…”

Section: Functional Groups Characterizationmentioning

confidence: 99%

“…The physiochemical properties of biomaterials are known to influence the ion-exchange, protein adsorption, cellular behavior, mechanical properties, and biodegradation rate that in turn determine the overall bioactivity and clinical performances of biomaterials. 3,4 To that end, different synthesis methods have been introduced using a wide range of precursor raw materials (e.g., CaHPO 4 , Ca 2 P 2 O 7 , CaCO 3 , CaO, Ca(OH) 2 , etc.). The synthesis methods include; precipitation and co-precipitation, sol-gel techniques, hydrothermal synthesis, mechano-chemical, plasma spray process, microwave sintering, hydrolysis, and laser-induced techniques.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and characterization of biomimetic bioceramic nanoparticles with optimized physicochemical properties for bone tissue engineering

Ebrahimi

Botelho

et al. 2019

J Biomedical Materials Res

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Calcium phosphate bioceramics nanoparticles such as nano‐hydroxyapatite (nHA) and nano‐tricalcium phosphate (nTCP) are the main focus of basic and applied research for bone tissue regeneration. In particular, a combination of these two phases (nHA + nTCP) which refers to as “nano‐biphasic calcium phosphates (nBCP)” is of interest due to the preferred biodegradation nature compared to single‐phase bioceramics. However, the available synthesis processes are challenging and the biomaterials properties are yet to be optimized to mimic the physiochemical properties of the natural nanoscale bone apatite. In this study, a new approach was developed for the production of optimized bioceramic nanoparticles aiming to improve their biomimecity for better biological performances. Nanoparticles were synthesized through a carefully controlled and modified wet mechano‐chemical method combined with a controlled solid‐state synthesis. Different processing variables have been analyzed including; milling parameters, post‐synthesis treatment, and calcination phase. Detailed physicochemical characterizations of nanoparticles revealed higher crystallinity (∼100%), lower crystallite/particle size (58 nm), higher homogeneity, reduced particle agglomeration size (6 μm), and a closer molar ratio (1.8) to biological apatite compared to control and standard samples. Furthermore, the study group was confirmed as calcium‐deficient carbonate‐substituted BCP nanoparticles (nHA/nβ‐TCP: 92/8%). As such, the introduced method can afford an easier and accurate control over nanoparticle physiochemical properties including the composition phase which can be used for better customization of biomaterials for clinical applications. The findings of this article will also help researchers in the further advancement of production strategies of biomaterials. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1654–1666, 2019.

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Section: Functional Groups Characterizationmentioning

confidence: 96%

Section: Functional Groups Characterizationmentioning

confidence: 97%

Section: Functional Groups Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis and characterization of biomimetic bioceramic nanoparticles with optimized physicochemical properties for bone tissue engineering

Ebrahimi

Botelho

et al. 2019

J Biomedical Materials Res

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“…Biomaterials are also used to fill defects and compensate lost part of bone tissue at the defect site. Bone substitutes that belong to a group of bioactive biomaterials are capable for interaction with the biological environment and can provide conditions for cellular actions [40] which is of benefit for bone regeneration. Nowadays, many different synthetic and natural bone substitutes are reported to be in use [10,40,41].…”

Section: Bone Substitutes and Regulatory Factorsmentioning

confidence: 99%

Application of Adipose-Derived Stem Cells in Treatment of Bone Tissue Defects

Najman¹,

Najdanović²,

Cvetković³

2021

Clinical Implementation of Bone Regeneration and Maintenance

Self Cite

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Despite excellent self-regeneration capacity of bone tissue, there are some large bone defects that cannot be healed spontaneously. Numerous literature data in the field of cell-based bone tissue engineering showed that adipose-derived stem cells (ADSCs) after isolation could be subsequently applied in a one-step approach for treatment of bone defect, without previous in vitro expansion and osteoinduction. However, standard approaches usually involve in vitro expansion and osteoinduction of ADSCs as an additional preparation step before its final application. Bioreactors are also used for the preparation of ADSC-based graft prior application. The commonly used approaches are reviewed, and their outcomes, advantages, disadvantages, as well as their potential for successful application in the treatment of bone defects are discussed. Difficulty in spontaneous healing of bone defects is very often due to poor vascularization. To overcome this problem, numerous methods in bone tissue engineering (BTE) were developed. We focused on freshly isolated stromal vascular fraction (SVF) cells and ADSCs in vitro induced into endothelial cells (ECs) as cells with vasculogenic capacity for the further application in bone defect treatment. We have reviewed orthotopic and ectopic models in BTE that include the application of SVFs or ADSCs in vitro induced into ECs, with special reference to co-cultivation.

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Design of Recombinant Spider Silk Proteins for Cell Type Specific Binding

Trossmann

Scheibel

2023

Adv Healthcare Materials

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Cytophilic (cell‐adhesive) materials are very important for tissue engineering and regenerative medicine. However, for engineering hierarchically organized tissue structures comprising different cell types, cell‐specific attachment and guidance are decisive. In this context, materials made of recombinant spider silk proteins are promising scaffolds, since they exhibit high biocompatibility, biodegradability, and the underlying proteins can be genetically functionalized. Here, previously established spider silk variants based on the engineered Araneus diadematus fibroin 4 (eADF4(C16)) are genetically modified with cell adhesive peptide sequences from extracellular matrix proteins, including IKVAV, YIGSR, QHREDGS, and KGD. Interestingly, eADF4(C16)‐KGD as one of 18 tested variants is cell‐selective for C2C12 mouse myoblasts, one out of 11 tested cell lines. Co‐culturing with B50 rat neuronal cells confirms the cell‐specificity of eADF4(C16)‐KGD material surfaces for C2C12 mouse myoblast adhesion.

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Bioactive Biomaterials: Potential for Application in Bone Regenerative Medicine

Cited by 8 publications

References 152 publications

Synthesis and characterization of biomimetic bioceramic nanoparticles with optimized physicochemical properties for bone tissue engineering

Synthesis and characterization of biomimetic bioceramic nanoparticles with optimized physicochemical properties for bone tissue engineering

Application of Adipose-Derived Stem Cells in Treatment of Bone Tissue Defects

Design of Recombinant Spider Silk Proteins for Cell Type Specific Binding

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