Bioactive atropisomers: Unraveling design strategies and synthetic routes for drug discovery
Shuai‐Jiang Liu,
Qian Zhao,
Xiao‐Chen Liu
et al.
Abstract:Atropisomerism, an expression of axial chirality caused by limited bond rotation, is a prominent aspect within the field of medicinal chemistry. It has been shown that atropisomers of a wide range of compounds, including established FDA‐approved drugs and experimental molecules, display markedly different biological activities. The time‐dependent reversal of chirality in atropisomers poses complexity and obstacles in the process of drug discovery and development. Nonetheless, recent progress in understanding a… Show more
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